Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Inhibiting Autophagy

(2013) Michael T. Lotze et al.   CANCER JOURNAL

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts

(2013) Brendan F Boyce   JOURNAL OF BONE AND MINERAL RESEARCH

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

(2013) Yichuan Xiao et al.   NATURE MEDICINE

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells

(2012) L. M. Calvi et al.   BLOOD

Autophagy is required for the activation of NFκB

(2012) Alfredo Criollo et al.   CELL CYCLE

The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis

(2012) Irina Voronov et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

Hydroxychloroquine: From Malaria to Autoimmunity

(2011) Ilan Ben-Zvi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Induction of the Alternative NF- B Pathway by Lymphotoxin    (LT  ) Relies on Internalization of LT  Receptor

(2011) C. Ganeff et al.   MOLECULAR AND CELLULAR BIOLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Pharmacogenetics: implications for therapy in rheumatic diseases

(2011) Lesley Davila et al.   Nature Reviews Rheumatology

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

(2011) A. Parkhitko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis

(2011) Tobias Braun et al.   ARTHRITIS RESEARCH & THERAPY

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

(2010) Pradeep Bista et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone

(2010) J.M. Hock et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD

(2010) Lishu Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced Inflammatory Osteolysis

(2010) Chang Yang et al.   PLoS One

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Transcriptional regulation of bone and joint remodeling by NFAT

(2009) Despina Sitara et al.   IMMUNOLOGICAL REVIEWS

Proteasome inhibitors impair RANKL-induced NF-κB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IκBα signaling cascades

(2009) Estabelle Ang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

p65/RelA Modulates BECN1 Transcription and Autophagy

(2009) T. Copetti et al.   MOLECULAR AND CELLULAR BIOLOGY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

(2009) Peyman Nakhaei et al.   PLoS Pathogens

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

VEGF-C, a Lymphatic Growth Factor, Is a RANKL Target Gene in Osteoclasts That Enhances Osteoclastic Bone Resorption through an Autocrine Mechanism

(2008) Qian Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

(2008) Sergio Vaira et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

RelB is the NF- B subunit downstream of NIK responsible for osteoclast differentiation

(2008) S. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of canonical NF- B activation through the NIK-IKK complex pathway

(2008) B. Zarnegar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA