期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1799, 期 1-2, 页码 157-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2009.11.002
关键词
High-mobility group protein; Alarmin; Dendritic cells; Immune response
资金
- NATIONAL CANCER INSTITUTE [ZIABC009369] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z01 BC009369-18] Funding Source: Medline
High-mobility group (HIVIG) proteins are non-histone nuclear proteins that bind nucleosomes and regulate chromosome architecture and gene transcription. Over the past decade, numerous studies have established that some HMG proteins can be released extracellularly and demonstrate distinct extracellular biological activities. Here, we will give a brief overview of HIVIG proteins and highlight their participation in innate/inflammatory and adaptive immune responses. They have the activities of alarmins, which are endogenous mediators that are rapidly released in response to danger signals initiated by infection and/or tissue damage and are capable of activating innate and adaptive immunity by promoting the recruitment and activation of antigen-presenting cells (APCs). (C) 2009 Published by Elsevier B.V.
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