Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases

Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes

(2011) D. Gutowska-Owsiak et al.   BRITISH JOURNAL OF DERMATOLOGY

SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing

(2011) Takeshi Matsui et al.   EMBO Molecular Medicine

Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis

(2011) Aleksandra Lesiak et al.   EXPERIMENTAL DERMATOLOGY

Regulation of caspase 14 expression in keratinocytes by inflammatory cytokines - a possible link between reduced skin barrier function and inflammation?

(2011) Malene Hvid et al.   EXPERIMENTAL DERMATOLOGY

Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

(2011) Xiuju Dai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

(2011) Sara J. Brown et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome

(2011) Takeshi Ouchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-α Downregulates Filaggrin and Loricrin through c-Jun N-terminal Kinase: Role for TNF-α Antagonists to Improve Skin Barrier

(2011) Byung Eui Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Filaggrin Gene Defects Are Independent Risk Factors for Atopic Asthma in a Polish Population: A Study in ECAP Cohort

(2011) Joanna Ponińska et al.   PLoS One

Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids

(2010) Noriko Ogasawara et al.   ACTA OTO-LARYNGOLOGICA

Loss of Corneodesmosin Leads to Severe Skin Barrier Defect, Pruritus, and Atopy: Unraveling the Peeling Skin Disease

(2010) Vinzenz Oji et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract

(2010) Catharina Sagita Moniaga et al.   AMERICAN JOURNAL OF PATHOLOGY

From atopic dermatitis to asthma: the atopic march

(2010) Jonathan M. Spergel   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population

(2010) J.P. Thyssen et al.   BRITISH JOURNAL OF DERMATOLOGY

Strain-Specific Phenotypes of Airway Inflammation and Bronchial Hyperresponsiveness Induced by Epicutaneous Allergen Sensitization in BALB/c and C57BL/6 Mice

(2010) Motohiro Kodama et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

An update on the genetics of atopic dermatitis: Scratching the surface in 2009

(2010) Kathleen C. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2–Toll-like receptor 6 pathway

(2010) Anh Tuan Vu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tight junction defects in patients with atopic dermatitis

(2010) Anna De Benedetto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bleomycin Hydrolase Is Regulated Biphasically in a Differentiation- and Cytokine-dependent Manner

(2010) Yayoi Kamata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

(2010) Chrystelle Bonnart et al.   JOURNAL OF CLINICAL INVESTIGATION

Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function

(2010) Shohei Kuroda et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Progress in Epidermolysis Bullosa Research: Toward Treatment and Cure

(2010) Jouni Uitto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-25 in Atopic Dermatitis: A Possible Link between Inflammation and Skin Barrier Dysfunction?

(2010) Malene Hvid et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A pilot study of emollient therapy for the primary prevention of atopic dermatitis

(2010) Eric L. Simpson et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

In vivo function of Langerhans cells and dermal dendritic cells

(2010) Daniel H. Kaplan   TRENDS IN IMMUNOLOGY

Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure

(2009) M. L. A. Schuttelaar et al.   ALLERGY

Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes

(2009) T. Kato et al.   ALLERGY

Epithelial Tight Junctions in Intestinal Inflammation

(2009) Joerg D. Schulzke et al.   Annals of the New York Academy of Sciences

FLGmutations in ichthyosis vulgaris and atopic eczema: spectrum of mutations and population genetics

(2009) M. Akiyama   BRITISH JOURNAL OF DERMATOLOGY

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

(2009) Tiffany C. Scharschmidt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease

(2009) Elke Rodríguez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutral Cysteine Protease Bleomycin Hydrolase Is Essential for the Breakdown of Deiminated Filaggrin into Amino Acids

(2009) Yayoi Kamata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filaggrin in the frontline: role in skin barrier function and disease

(2009) A. Sandilands et al.   JOURNAL OF CELL SCIENCE

Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice

(2009) Andreas Elentner et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

(2009) Akiharu Kubo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epidermal Barrier Dysfunction in Atopic Dermatitis

(2009) Michael J. Cork et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

(2009) Padraic G Fallon et al.   NATURE GENETICS

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions

(2009) K. Nagao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging roles of serine protease cascades in the epidermis

(2009) Petra Ovaere et al.   TRENDS IN BIOCHEMICAL SCIENCES

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults

(2008) K. Basu et al.   ALLERGY

Primary immune deficiencies with aberrant IgE production

(2008) Esra Ozcan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin in atopic dermatitis

(2008) Grainne M. O'Regan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin Expression in Oral, Nasal, and Esophageal Mucosa

(2008) Anna De Benedetto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE

Tight junction-based epithelial microenvironment and cell proliferation

(2008) S Tsukita et al.   ONCOGENE

Loss-of-Function Mutations in the Filaggrin Gene and Allergic Contact Sensitization to Nickel

(2007) Natalija Novak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Co-Regulation and Interdependence of the Mammalian Epidermal Permeability and Antimicrobial Barriers

(2007) Karin M. Aberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of Proteinase-Activated Receptor-2 by Human Kallikrein-Related Peptidases

(2007) Kristina Stefansson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The filaggrin story: novel insights into skin-barrier function and disease

(2007) John A. McGrath et al.   TRENDS IN MOLECULAR MEDICINE