期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 125, 期 1, 页码 16-29出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2009.11.008
关键词
Atopic dermatitis; genetics; IgE-mediated response; innate immunity; skin barrier dysfunction; genetic association; gene-environment interaction; ethnicity
资金
- National Institute of Health (National Institute of Allergy and Infectious Diseases) [HSN266200400029C]
A genetic basis for atopic dermatitis (AD) has long been recognized. Historic documents allude to family history of disease as a risk factor. Before characterization of the human genome, heritability studies combined with family-based linkage studies supported the definition of AD as a complex trait in that interactions between genes and environmental factors and the interplay between multiple genes contribute to disease manifestation. A summary of more than 100 published reports on genetic association studies through mid-2009 implicates 81 genes, in 46 of which at least I positive association with AD has been demonstrated. Of these, the gene encoding filaggrin (FLG) has been most consistently replicated. Most candidate gene studies to date have focused on adaptive and innate immune response genes, but there is increasing interest in skin barrier dysfunction genes. This review examines the methods that have been used to identify susceptibility genes for AD and bow the underlying pathology of this disease has been used to select candidate genes. Current challenges and the potential effect of new technologies are discussed. (J Allergy Clin Immunol 2010;125:16-29.)
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