Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors

(2012) Iannis E Adamopoulos et al.   ARTHRITIS RESEARCH & THERAPY

Bisphosphonates Cause Osteonecrosis of the Jaw-Like Disease in Mice

(2010) Yanming Bi et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of antiresorptive agents on osteomyelitis

(2010) Dan Li et al.   Annals of the New York Academy of Sciences

Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression

(2010) G. R. Heiland et al.   ANNALS OF THE RHEUMATIC DISEASES

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

(2010) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation

(2010) Kenjiro Bandow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells

(2010) H. Li et al.   BLOOD

T cells: Critical bone regulators in health and disease

(2010) Roberto Pacifici   BONE

Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblasts

(2010) Amy B. Young et al.   BONE

Evidence for interleukin-1β production by cultured normal human osteoblast-like cells

(2010) Philip E. Keeting et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pathophysiology of primary hyperparathyroidism

(2010) Allen M. Spiegel   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammation and Uncoupling as Mechanisms of Periodontal Bone Loss

(2010) D.T. Graves et al.   JOURNAL OF DENTAL RESEARCH

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

(2010) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

(2010) Eva Gonzalez-Suarez et al.   NATURE

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss

(2010) Hesham Tawfeek et al.   PLoS One

Bone Damage in Rheumatoid Arthritis: Mechanistic Insights and Approaches to Prevention

(2010) Sougata Karmakar et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma

(2009) Ravi Vij et al.   AMERICAN JOURNAL OF HEMATOLOGY

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

(2009) M. Fulciniti et al.   BLOOD

Cancer stem cells and their niche

(2009) Hiroko Iwasaki et al.   CANCER SCIENCE

New biologics for psoriasis and psoriatic arthritis

(2009) Mariya Rozenblit et al.   Dermatologic Therapy

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

(2009) Takako Negishi-Koga et al.   IMMUNOLOGICAL REVIEWS

Mouse macrophages primed with al“endronate down-regulate monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1α (MIP-1α) production in response to Toll-like receptor (TLR) 2 and TLR4 agonist via Smad3 activation

(2009) Takahiro Masuda et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Osteoblast Function Is Compromised at Sites of Focal Bone Erosion in Inflammatory Arthritis

(2009) Nicole C Walsh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy

(2009) David L Kendler et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-  in Human Osteoclast Precursors

(2009) J.-D. Ji et al.   JOURNAL OF IMMUNOLOGY

Osteoimmunology and the effects of the immune system on bone

(2009) Hiroshi Takayanagi   Nature Reviews Rheumatology

Effect of bisphosphonates on pain and quality of life in patients with bone metastases

(2009) Luis Costa et al.   Nature clinical practice. Oncology

Clinical update on teriparatide

(2009) Elizabeth File et al.   Current Rheumatology Reports

Denosumab: Anti-RANKL antibody

(2009) Paul D. Miller   Current Osteoporosis Reports

CTLA-4 directly inhibits osteoclast formation

(2008) R Axmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis

(2008) H Kelchtermans et al.   ANNALS OF THE RHEUMATIC DISEASES

Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate

(2008) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: Fibroblast-mediated pathologic bone resorption

(2008) Miklos Tunyogi-Csapo et al.   ARTHRITIS AND RHEUMATISM

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Taking a Toll on the bones: Regulation of bone metabolism by innate immune regulators

(2008) Zvi Bar-Shavit   AUTOIMMUNITY

Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis

(2008) Patrizia D'Amelio et al.   BONE

Infantile Malignant, Autosomal Recessive Osteopetrosis: The Rich and The Poor

(2008) Anna Villa et al.   CALCIFIED TISSUE INTERNATIONAL

T Cells Potentiate PTH-Induced Cortical Bone Loss through CD40L Signaling

(2008) Yuhao Gao et al.   Cell Metabolism

Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3

(2008) D. Varoga et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis

(2008) Erika H. Noss et al.   IMMUNOLOGICAL REVIEWS

The role of human β-defensin-2 in bone

(2008) D. Varoga et al.   JOURNAL OF ANATOMY

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

(2008) Antonios O. Aliprantis et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic Stem Cell Based Intervention as a New Approach to Osteoporosis Treatment in Rodents

(2008) Takayoshi Yamaza et al.   PLoS One

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-  and IL-17

(2008) M. Hashizume et al.   RHEUMATOLOGY

Immune regulation of bone loss by Th17 cells

(2008) Iannis E Adamopoulos et al.   ARTHRITIS RESEARCH & THERAPY