Article
Immunology
Andrew D. Hildreth, Feiyang Ma, Yung Yu Wong, Ryan Sun, Matteo Pellegrini, Timothy E. O'Sullivan
Summary: This study provides a comprehensive analysis of the cellular composition in healthy and obese human white adipose tissue, revealing changes in immune cell populations and inflammatory pathways in obese individuals. The findings highlight the importance of immune cell regulation in metabolic diseases and offer insights into new cellular networks and differentiation trajectories in white adipose tissue.
Review
Pharmacology & Pharmacy
Marjorie Reyes-Farias, Julia Fos-Domenech, Dolors Serra, Laura Herrero, David Sanchez-Infantes
Summary: Both obesity and aging are linked to metabolic diseases like type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose tissue plays a role in the progression of these diseases. Obesity and aging lead to alterations in adipose tissue, triggering a pro-inflammatory phenotype in resident immune cells. They also share characteristics such as a higher visceral fat to subcutaneous fat ratio and a reduced lifespan.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Aline Almeida da Silva, Elisangela Martins da Silva Perez, Ingrid Samantha Tavares de Figueiredo, Nylane Maria Nunes de Alencar, Ana Paula Negreiros Nunes Alves, Fabiano Andre Narciso Fernandes, Renata Prado Vasconcelos, Ariclecio Cunha de Oliveira, Socorro Vanesca Frota Gaban
Summary: This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. The results showed that low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.
Article
Pharmacology & Pharmacy
Antoni Olona, Charlotte Hateley, Ana Guerrero, Jeong-Hun Ko, Michael R. Johnson, Paras K. Anand, David Thomas, Jesus Gil, Jacques Behmoaras
Summary: The study shows that cardiac glycosides such as ouabain can induce cytotoxicity in macrophages and have potential effects on human tissues. Ouabain triggers pyroptosis and apoptosis, with a stronger effect on monocyte-derived macrophages and influenced by K+ flux. Furthermore, treatment with ouabain in adipose tissue from obese patients results in improved insulin sensitivity and reduction of macrophages.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Mingzhu Yan, Suwei Jin, Zhi Wang, Tianji Xia, Yongguang Liu, Qi Chang
Summary: Limonin, a compound found in citrus fruits, has been found to effectively combat obesity by reducing fat mass and body weight gain, and improving fatty liver and hyperlipidemia caused by a high-fat diet. It also promotes the browning of white adipose tissues and prevents the whitening of brown adipose tissue in mice. These effects are associated with the activation of PGC-1 alpha pathway. Overall, limonin shows great potential for regulating energy balance and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Aliki Perdikari, Tessa Cacciottolo, Elana Henning, Edson Mendes de Oliveira, Julia M. Keogh, I. Sadaf Farooqi
Summary: Obesity is a major health issue, but the structure and function of human adipose tissue have been difficult to understand due to the limitations in visualizing cellular components. In this study, we developed a protocol using staining and clearing techniques to visualize human subcutaneous white adipose tissue and successfully visualized sympathetic nerve terminals.
Review
Cell Biology
Alina Kurylowicz
Summary: MiRNAs play a crucial role in regulating adipose tissue physiology and can impact overall metabolism by controlling the function of adipose tissue. Dysfunctional adipocytes may impair the function of other organs and tissues through secreted mediators. MiRNAs have the potential to be critical therapeutic targets for treating obesity and related metabolic complications.
Article
Endocrinology & Metabolism
Long Cheng, Shuofeng Zhang, Fei Shang, Yibo Ning, Zhiqi Huang, Runcheng He, Jianning Sun, Shifen Dong
Summary: The study found that emodin could reduce body weight and food intake in obese mice, improve glucose tolerance, and decrease blood lipids. Emodin treatment induced beiging of white adipose tissue and increased markers of beige adipocytes in subcutaneous white adipose tissue (scWAT) and brown adipose tissue (BAT). Furthermore, emodin perturbed the lipidomic profiles in scWAT and BAT of obese mice, indicating selective remodeling in tissue lipid content in response to emodin treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Julia Rogal, Julia Roosz, Claudia Teufel, Madalena Cipriano, Raylin Xu, Wiebke Eisler, Martin Weiss, Katja Schenke-Layland, Peter Loskill
Summary: Obesity and associated diseases have become epidemic globally. Researchers have developed a microphysiological in vitro model of human white adipose tissue, leveraging Organ-on-Chip technology, which can recapitulate crucial adipose tissue functions and offers advantages such as low inter-donor variability and controllability, making it a valuable tool for metabolism research and personalized medicine applications.
Article
Endocrinology & Metabolism
Cheryl Li, Xenia Davis, Patrick Lahni, Joanna Stuck, Lauren Williamson, Jennifer Kaplan
Summary: White adipose tissue browning is detrimental in patients with burn injury and cancer. WAT browning occurs in nonobese mice and can be induced by beta receptor norepinephrine infusion, but obese mice are resistant to sepsis-induced and norepinephrine-induced WAT browning. Obese mice may be protected from sepsis due to the lack of WAT browning and unchanged inflammatory cytokine response.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Review
Nutrition & Dietetics
Natalia Santillana, Camila Astudillo-Guerrero, Amanda D'Espessailles, Gonzalo Cruz
Summary: White adipose tissue dysfunction is crucial in the pathogenesis of cardiometabolic alterations related to obesity. Dysfunction is characterized by limited expansion capacity, increased adipocyte hypertrophy, altered adipokine secretion, macrophage accumulation and inflammation. Simple tools are needed to identify individuals with dysfunctional adipose tissue who are at risk of developing metabolic alterations. This review highlights the current pathophysiological mechanisms and emerging measurements for assessing white adipose tissue functionality.
Review
Nutrition & Dietetics
Luca Colangeli, David Israel Escobar Marcillo, Valeria Simonelli, Egidio Iorio, Tommaso Rinaldi, Paolo Sbraccia, Paola Fortini, Valeria Guglielmi
Summary: Adipose tissue dysregulation is a critical process in obesity and its related complications, but the molecular basis of this dysfunction is still not fully understood. Recent research suggests that mitochondria, the cellular organelles responsible for energy production, play an important role in adipose tissue metabolism and function. Additionally, the dysregulation of gut microbiota and its metabolites in obesity may directly and indirectly affect adipose tissue metabolism through its impact on mitochondria. This review explores the connections between gut microbiota and adipose tissue mitochondria and provides insights into their molecular interactions.
Article
Food Science & Technology
Lin Ding, Jinyue Yang, Haoran Guo, Peixu Cong, Jie Xu, Changhu Xue, Xiangzhao Mao, Tiantian Zhang, Yuming Wang
Summary: Dietary supplementation of docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) in the form of phosphoethanolamine plasmalogens (PlsEtn) has been shown to remodel lipidome and regulate fatty acid metabolic process in white adipose tissue (WAT), suggesting it as a potential strategy for obesity treatment in the future.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Agne Kulyte, Veroniqa Lundback, Cecilia M. Lindgren, Jian'an Luan, Luca A. Lotta, Claudia Langenberg, Peter Arner, Rona J. Strawbridge, Ingrid Dahlman
MOLECULAR METABOLISM
(2020)
Article
Cell Biology
Veroniqa Lundback, Agne Kulyte, Peter Arner, Rona J. Strawbridge, Ingrid Dahlman
Letter
Cell Biology
Hui Gao, Peter Arner, Gallic Beauchef, Christelle Guere, Katell Vie, Ingrid Dahlman, Niklas Mejhert, Mikael Ryden
Article
Cell Biology
Jeremy Dufau, Joanne X. Shen, Morgane Couchet, Thais De Castro Barbosa, Niklas Mejhert, Lucas Massier, Elena Griseti, Etienne Mouisel, Ez-Zoubir Amri, Volker M. Lauschke, Mikael Ryden, Dominique Langin
Summary: Adipocytes play diverse roles in physiology and pathology, with white, beige, and brown adipocytes differing in their lipid handling and thermogenic capacity. Cultured differentiated preadipocyte cell lines and primary mature adipocytes are used to mimic different types of adipocytes, but challenges remain in culture conditions and limitations. Advances in three-dimensional culture, such as adipose spheroids, provide a more in vivo-like model for studying adipocyte function and morphology.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Regine A. Jersin, Divya Sri Priyanka Tallapragada, Andre Madsen, Linn Skartveit, Even Fjaere, Adrian McCann, Laurence Dyer, Aron Willems, Jan-Inge Bjune, Mona S. Bjune, Villy Vage, Hans Jorgen Nielsen, Havard Luong Thorsen, Bjorn Gunnar Nedrebo, Christian Busch, Vidar M. Steen, Matthias Blueher, Peter Jacobson, Per-Arne Svensson, Johan Ferno, Mikael Ryden, Peter Arner, Ottar Nygard, Melina Claussnitzer, Stale Ellingsen, Lise Madsen, Jorn V. Sagen, Gunnar Mellgren, Simon N. Dankel
Summary: This study reveals that the small neutral amino acid transporter SLC7A10 plays a significant role in regulating adipocyte resilience to nutrient and oxidative stress, reducing reactive oxygen species generation and lipid accumulation, and improving mitochondrial respiration, ultimately leading to decreased adipocyte hypertrophy, insulin resistance, and type 2 diabetes.
Article
Biology
Carl Herdenberg, Pascal M. Mutie, Ola Billing, Ahmad Abdullah, Rona J. Strawbridge, Ingrid Dahlman, Simon Tuck, Camilla Holmlund, Peter Arner, Roger Henriksson, Paul W. Franks, Hakan Hedman
Summary: Herdenberg et al. demonstrate that adipogenesis and BMP signaling are disrupted in mouse cells lacking LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They also show that mutant LRIG/sma-10 variant worms exhibit defects in lipid storage and human LRIG1 variants are linked to higher body mass index while protecting against type 2 diabetes. This study suggests a conserved role of LRIG proteins in lipid metabolism and BMP signaling across different species.
COMMUNICATIONS BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Summary: White adipocyte metabolism plays a crucial role in systemic metabolism regulation and is often disrupted in conditions like cancer and type 2 diabetes mellitus. This review provides an overview of lipid metabolism in white adipocytes and discusses how these pathways can serve as therapeutic targets in metabolic disorders.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Enrichetta Mileti, Kelvin H. M. Kwok, Daniel P. Andersson, Anthony Mathelier, Amitha Raman, Jesper Backdahl, Jutta Jalkanen, Lucas Massier, Anders Thorell, Hui Gao, Peter Arner, Niklas Mejhert, Carsten O. Daub, Mikael Ryden
Summary: Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. This study showed that white adipose tissue in obese individuals also displays a selective insulin response, which is normalized by weight loss in most genes.
Article
Cell Biology
Jesper Baeckdahl, Lovisa Franzen, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Ryden, Patrik L. Stahl, Niklas Mejhert
Summary: By studying the composition and structure of WAT, we identified that human WAT is composed of three classes of mature adipocytes, only one of which is insulin responsive.
Article
Nutrition & Dietetics
Miroslav Vujasinovic, Lorena Nezirevic Dobrijevic, Ebba Asplund, Wiktor Rutkowski, Ana Dugic, Mashroor Kahn, Ingrid Dahlman, Maria Saaf, Hannes Hagstrom, Johannes-Matthias Lohr
Summary: This study found that only 23% of patients with CP underwent DXA examination, with 53.4% of patients having low BMD. The fracture rate was significantly higher in patients with low BMD compared to those with normal BMD.
Article
Chemistry, Multidisciplinary
Joanne X. Shen, Morgane Couchet, Jeremy Dufau, Thais de Castro Barbosa, Maximilian H. Ulbrich, Martin Helmstadter, Aurino M. Kemas, Reza Zandi Shafagh, Marie-Adeline Marques, Jacob B. Hansen, Niklas Mejhert, Dominique Langin, Mikael Ryden, Volker M. Lauschke
Summary: A scaffold-free versatile 3D adipocyte culture platform was developed in this study, accurately recapitulating adipogenesis with mature molecular and cellular phenotypes.
Editorial Material
Endocrinology & Metabolism
Niklas Mejhert, Mikael Ryden
Summary: Nelson and colleagues compared insulin resistance in different inbred mouse strains fed different diets. They found significant strain-related differences in weight gain and insulin action, and demonstrated that tissue-specific insulin sensitivity can be studied separately.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Sara Nikolic, Patrick Maisonneuve, Ingrid Dahlman, J-Matthias Lohr, Miroslav Vujasinovic
Summary: The prevalence of endocrine and exocrine insufficiency is high in patients with autoimmune pancreatitis (AIP), and there is a risk of developing pancreatic exocrine insufficiency (PEI) and diabetes mellitus (DM) despite pharmacological treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
