Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Montano, Alondra del Carmen Ruiz-Gutierrez, Vianeth Maria del Carmen Martinez-Rodriguez, Juan Ramon Gomez-Sandoval, Juan Manuel Guzman-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velazquez
Summary: This study found that patients with periodontitis have significantly lower levels of IL-17A in plasma, but higher levels of IL-23, IL-17A, and IL-17RA in gingival tissue. Several correlations were also found, suggesting a potential role of the IL-23/IL-17A axis in the progression of periodontitis.
APPLIED SCIENCES-BASEL
(2022)
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Immunology
Mohamed Mandour, Sijia Chen, Marleen G. H. van de Sande
Summary: Spondyloarthritis (SpA) is a chronic inflammatory joint disease where the IL-23/IL-17 pathway and TNF-α cytokine play important roles in its pathogenesis. Animal models have provided new insights into molecular mechanisms at different stages of SpA, aiding in understanding disease initiation and potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohammed El-Gedamy, Zakaria El-khayat, Hassan Abol-Enein, Afaf El-said, Eslam El-Nahrery
Summary: The genetic variant rs1884444 G/T of IL-23R is significantly associated with a reduced risk of bladder urothelial carcinoma (BUC), with the T allele potentially serving as a reliable genetic marker for good prognosis. The G/T variation may regulate BUC risk through modulation of the IL-23/IL-17 pathway.
Article
Ophthalmology
Pengbo Zhang, Xibo Zhang, Fen Xu, Wangdong Xu, Huang Zhu
Summary: This study found that IL-12, IL-27, and IL-35 may serve as biomarkers for TAO, and the levels of IL-27 and IL-35 were elevated in TAO patients while IL-12 levels were decreased.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Hao Li, George C. Tsokos
Summary: Inflammatory rheumatic disorders involve the immune system attacking connective tissues and internal organs. Advances in understanding the cellular and molecular mechanisms have led to targeting the IL-23/IL-17 axis therapeutically, resulting in clinical benefits. The complicated interrelationship between IL-23 and IL-17 may be uncoupled in certain disease settings.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Angela Ceribelli, Francesca Motta, Matteo Vecellio, Natasa Isailovic, Francesco Ciccia, Carlo Selmi
Summary: Spondyloarthritis (SpA) is a group of inflammatory musculoskeletal diseases with common genetic backgrounds, and IL-17 and IL-23 have been identified as key cytokines in its pathogenesis. Treatment options for axial SpA differ significantly from peripheral arthritis, with new therapies targeting these cytokines showing promising results for both axial psoriatic arthritis and ankylosing spondylitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Yang Jiang, Yajie Dai, Zhenquan Liu, Yan Liao, Shuyong Sun, Xianghe Kong, Jingjing Hu, Yibo Tang
Summary: Bidirectional communication between the central nervous system (CNS) and intestine is mediated by various pathways in the gut-brain axis. Disturbance in the homeostasis of intestine and gut microbiota can lead to CNS diseases, while dysbiosis of intestinal and gut microbiota can worsen the progression of CNS diseases. The IL-23/IL-17 axis has been found to play an important role in CNS diseases such as experimental autoimmune encephalomyelitis (EAE), multiple sclerosis (MS), and ischemic stroke (IS). This review focuses on the relationship between the IL-23/IL-17 axis and IS from the perspective of the gut-brain axis, aiming to provide insights for the treatment strategies of IS.
Review
Ophthalmology
Zhenyu Zhong, Guannan Su, Aize Kijlstra, Peizeng Yang
Summary: Uveitis is a group of diseases characterized by intraocular inflammation, some of which are driven by auto inflammatory or autoimmune responses, and share the activation of the IL-23/IL-17 pathway. Emerging drugs blocking this pathway have been assessed for the treatment of uveitis.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Review
Food Science & Technology
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I'tishom, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: The development of Helicobacter pylori-related diseases is closely linked to chronic inflammation, which is significantly impacted by immune responses. Key cytokines such as IL-17, IL-21, and IL-23 play crucial roles in antimicrobial activity and pathogenic immune response, maintaining Th17 cells and accommodating humoral immune cells in the gut environment.
Review
Cardiac & Cardiovascular Systems
Akinori Higaki, Ahmad U. M. Mahmoud, Pierre Paradis, Ernesto L. Schiffrin
Summary: Hypertension is partially mediated by immune mechanisms, with IL-23 and IL-17 playing important roles. The IL-23/IL-17 axis has not been a major therapeutic target for hypertension treatment, but shows potential for targeting therapy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Ritu Sarin, Ran Gu, Zahra Jalali, Emanual Maverakis, Maria G. Tsokos, Iannis E. Adamopoulos
Summary: Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation and IL-27 also inhibits IL-23-induced inflammation associated with myeloid cell infiltration in the joints and spleen. The IL-27 anti-inflammatory response is associated with reduced levels of myeloid cells in the spleen and bone marrow.
CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Michal Swierniak, Anna Wojcicka, Malgorzata Czetwertynska, Joanna Dlugosinska, Elzbieta Stachlewska, Wojciech Gierlikowski, Adam Kot, Barbara Gornicka, Lukasz Koperski, Magdalena Bogdanska, Wieslaw Wiechno, Krystian Jazdzewski
CLINICAL CANCER RESEARCH
(2016)
Review
Endocrinology & Metabolism
Anna Wojcicka, Monika Kolanowska, Krystian Jazdzewski
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2016)
Review
Peripheral Vascular Disease
Dominika Klimczak, Krystian Jazdzewski, Marek Kuch
Article
Endocrinology & Metabolism
Barbara Jarzab, Marek Dedecjus, Daria Handkiewicz-Junak, Dariusz Lange, Andrzej Lewinski, Anna Nasierowska-Guttmejer, Marek Ruchala, Dorota Slowinska-Klencka, Janusz Nauman, Zbigniew Adamczewski, Maciej Baglaj, Agata Baldys-Waligorska, Marcin Barczynski, Tomasz Bednarczuk, Andrzej Cichocki, Agnieszka Czarniecka, Rafal Czepczynski, Aneta Gawlik, Alicja Hubalewska-Dydejczyk, Krystian Jazdzewski, Grzegorz Kaminski, Malgorzata Karbownik-Lewinska, Beata Kos-Kudla, Andrzej Kulakowski, Krzysztof Kuzdak, Katarzyna Lacka, Ewa Malecka-Tendera, Marek Niedziela, Lech Pomorski, Stanislaw Sporny, Zoran Stojcev, Anhelli Syrenicz, Jan Wloch, Jolanta Krajewska, Sylwia Szpak-Ulczok, Michal Kalemba, Monika Buziak-Bereza, Mariusz Klencki, Wojciech Rzeszutko, Maria Rzeszutko, Krzysztof Kaczka, Ryszard Anielski, Jan Sir, Janusz Dzieciol, Andrzej Namiot, Ewa Zembala-Nozynska, Malgorzata Janicka-Jedynska, Aleksandra Kukulska, Aleksandra Blewaska, Teresa Wojtala, Tomasz Stechly, Ewa Paliczka Cieslik, Aleksandra Kropinska, Aleksandra Krol, Tomasz Tomkalski, Aldona Wozniak
ENDOKRYNOLOGIA POLSKA
(2016)
Article
Oncology
Jerneja Tomsic, Rebecca Fultz, Sandya Liyanarachchi, Luke K. Genutis, Yanqiang Wang, Wei Li, Stefano Volinia, Krystian Jazdzewski, Huiling He, Paul E. Wakely, Leigha Senter, Albert de la Chapelle
Article
Immunology
Patrick C. Duncker, Joshua S. Stoolman, Amanda K. Huber, Benjamin M. Segal
JOURNAL OF IMMUNOLOGY
(2018)
Article
Oncology
Lukasz Koperski, Marta Kotlarek, Michal Swierniak, Monika Kolanowska, Anna Kubiak, Barbara Gornicka, Krystian Jazdzewski, Anna Wojcicka
Article
Endocrinology & Metabolism
Barbara Jarzab, Marek Dedecjus, Dorota Slowinska-Klencka, Andrzej Lewinski, Zbigniew Adamczewski, Ryszard Anielski, Maciej Baglaj, Agata Baldys-Waligorska, Marcin Barczynski, Tomasz Bednarczuk, Artur Bossowski, Monika Buziak-Bereza, Ewa Chmielik, Andrzej Cichocki, Agnieszka Czarniecka, Rafal Czepczynski, Janusz Dzieciol, Tomasz Gawlik, Daria Handkiewicz-Junak, Kornelia Hasse-Lazar, Alicja Hubalewska-Dydejczyk, Krystian Jazdzewski, Beata Jurecka-Lubieniecka, Michal Kalemba, Grzegorz Kaminski, Malgorzata Karbownik-Lewinska, Mariusz Klencki, Beata Kos-Kudla, Agnieszka Kotecka-Blicharz, Aldona Kowalska, Jolanta Krajewska, Aleksandra Kropinska, Aleksandra Kukulska, Emilia Kulik, Andrzej Kulakowski, Krzysztof Kuzdak, Dariusz Lange, Aleksandra Ledwon, Elzbieta Lewandowska-Jablonska, Andrzej Lewinski, Katarzyna Lacka, Barbara Michalik, Anna Nasierowska-Guttmejer, Janusz Nauman, Marek Niedziela, Ewa Malecka-Tendera, Malgorzata Oczko-Wojciechowska, Tomasz Olczyk, Ewa Paliczka-Cieslik, Lech Pomorski, Zbigniew Puch, Jozef Roskosz, Marek Ruchala, Dagmara Rusinek, Stanislaw Sporny, Agata-Stanek Widera, Zoran Stojcev, Aleksandra Sygula, Anhelli Syrenicz, Sylwia Szpak-Ulczok, Tomasz Tomkalski, Zbigniew Wygoda, Jan Wloch, Ewa Zembala-Nozynska
ENDOKRYNOLOGIA POLSKA
(2018)
Article
Biochemistry & Molecular Biology
Marta Kotlarek, Anna Kubiak, Malgorzata Czetwertynska, Michal Swierniak, Wojciech Gierlikowski, Monika Kolanowska, Elwira Bakula-Zalewska, Sissy M. Jhiang, Krystian Jazdzewski, Anna Wojcicka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Multidisciplinary Sciences
Monika Kolanowska, Anna Wojcicka, Anna Kubiak, Michal Swierniak, Marta Kotlarek, Monika Maciag, Pawel Gaj, Lukasz Koperski, Barbara Gornicka, Krystian Jazdzewski
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Justyna Augustyniak, Jacek Lenart, Pawel Gaj, Monika Kolanowska, Krystian Jazdzewski, Piotr Pawel Stepien, Leonora Buzanska
MOLECULAR NEUROBIOLOGY
(2019)
Article
Immunology
David M. Stepien, Charles Hwang, Simone Marini, Chase A. Pagani, Michael Sorkin, Noelle D. Visser, Amanda K. Huber, Nicole J. Edwards, Shawn J. Loder, Kaetlin Vasquez, Carlos A. Aguilar, Ravi Kumar, Shamik Mascharak, Michael T. Longaker, Jun Li, Benjamin Levi
JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Amanda K. Huber, Nicole Patel, Chase A. Pagani, Simone Marini, Karthik R. Padmanabhan, Daniel L. Matera, Mohamed Said, Charles Hwang, Ginny Ching-Yun Hsu, Andrea A. Poli, Amy L. Strong, Noelle D. Visser, Joseph A. Greenstein, Reagan Nelson, Shuli Li, Michael T. Longaker, Yi Tang, Stephen J. Weiss, Brendon M. Baker, Aaron W. James, Benjamin Levi
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Genetics & Heredity
Marcin Bednarek, Marek Trybus, Monika Kolanowska, Mateusz Koziej, Beata Kiec-Wilk, Artur Dobosz, Marta Kotlarek-Lysakowska, Anna Kubiak-Dydo, Ewelina Uzarowska-Gaska, Julia Starega-Roslan, Pawel Gaj, Izabela Gorzynska, Katarzyna Serwan, Michal Swierniak, Adam Kot, Krystian Jazdzewski, Anna Wojcicka
Summary: Brachydactylies are a group of inherited conditions characterized by shortened fingers and toes, with different subtypes caused by mutations in genes such as BMPR1B, BMP2, or GDF5. This study identified a family with two members affected by brachydactyly type A2, showing that the mutation in the BMPR1B gene occurred de novo in the proband and was transmitted to his son. Despite both patients having the same variant, their phenotypes differed with more severe manifestation in the adult.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Health Care Sciences & Services
Agnieszka Furmanczyk-Zawiska, Anna Kubiak-Dydo, Ewelina Uzarowska-Gaska, Marta Kotlarek-Lysakowska, Katarzyna Salata, Monika Kolanowska, Michal Swierniak, Pawel Gaj, Beata Leszczynska, Maria Daniel, Krystian Jazdzewski, Magdalena Durlik, Anna Wojcicka
Summary: Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by genetic defects, with variable clinical outcomes, including renal failure. This study presents cases of five family members affected by aHUS, demonstrating the highly variable penetrance of the disease.
JOURNAL OF PERSONALIZED MEDICINE
(2021)