Article
Pharmacology & Pharmacy
Danjie Zhang, Liangzhang Sun, Jin Zhang
Summary: TMED3 plays a pro-tumor role in NSCLC by enhancing Wnt/beta-catenin signaling through modulating AKT. Inhibition of TMED3 displays remarkable anti-tumor effects in vitro and in vivo, suggesting it may be a potential target for future targeted therapies in NSCLC management.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lihang Shen, Yang He, Shuo Chen, Linhai He, Yi Zhang
Summary: This study discovered that fibrous dysplasia (FD) patient-derived bone marrow stromal cells (FD BMSCs) exhibited significantly higher levels of PTHrP during osteogenic differentiation and had increased proliferation capacity but impaired osteogenic ability. Through the PTHrP/cAMP/PKA axis, PTHrP partially influenced the proliferation and osteogenic capacity of FD BMSCs by overactivating the Wnt/β-Catenin signaling pathway. This study provides new insights into the pathogenesis of FD and its molecular signaling pathways, offering theoretical evidence for potential therapeutic targets for FD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Wensi Wu, Xiaojun Zhang, Jiaxin Zhou, Hongmei Yang, Junjun Chen, Le Zhao, Junying Zhong, Wei-Jye Lin, Zhi Wang
Summary: Perioperative neurocognitive disorder (PND) leads to cognitive deterioration, especially in older patients, and demyelination is related to its pathogenesis. Clemastine, a drug known for its potency in remyelination, has shown potential therapeutic effects on PND by reducing inflammatory factors and enhancing remyelination.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amir Barzegar Behrooz, Zahra Talaie, Fatemeh Jusheghani, Marek J. Los, Thomas Klonisch, Saeid Ghavami
Summary: Glioblastoma (GBM) is a devastating type of brain tumor, and targeting the Wnt/β-catenin and PI3K/Akt/mTOR (PAM) signaling pathways, which play crucial roles in GBM progression and invasion, may provide important advancements in alternative treatment strategies for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hala El-Safty, Ashraf Ismail, Rania M. Abdelsalam, Ayman E. El-Sahar, Muhammed A. Saad
Summary: Dapagliflozin may have neuroprotective action and alleviate memory and cognition impairment caused by diabetic neuropathy through its antioxidant and anti-apoptotic properties.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Tomomitsu Doi, Hironori Hojo, Shinsuke Ohba, Kunie Obayashi, Motoyoshi Endo, Toshimasa Ishizaki, Akira Katoh, Hiroyuki Kouji
Summary: This study investigates the regulatory mechanisms underlying β-catenin coactivator usage in human pancreatic carcinoma cells. The results suggest that AP-1 may coordinate the usage of β-catenin coactivators in these cells.
Review
Genetics & Heredity
Midhuna Devanand, V. N. Saiprabha, Krishnadas Madhu
Summary: Multiple sclerosis is an autoimmune neurodegenerative disease that leads to progressive disabilities due to CNS axon degeneration caused by demyelination. Therapies targeting diverse signaling pathways involved in neuroprotection and remyelination have the potential to overcome the challenges in developing treatments for multiple sclerosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Sangeeta Ghuwalewala, Dishari Ghatak, Sumit Das, Stuti Roy, Pijush Das, Ramesh Butti, Mahadeo Gorain, Somsubhra Nath, Gopal C. Kundu, Susanta Roychoudhury
Summary: The study found an elevated expression of miR-146a in the CD44(high)CD24(low) population within OSCC cells and primary HNSCC tumors. Over-expression of miR-146a enhances stemness phenotype by stabilizing beta-catenin and resulting in loss of E-cadherin and CD24. CD24 is identified as a novel functional target of miR-146a, and mechanistic analysis reveals that higher CD24 levels inhibit AKT phosphorylation leading to beta-catenin degradation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Cassio Dejair Fleming-de-Moraes, Murilo Ramos Rocha, Josiane Weber Tessmann, Wallace Martins de Araujo, Jose Andres Morgado-Diaz
Summary: The interaction between PI3K/Akt and Wnt/β-catenin pathways contributes to colorectal cancer progression, promoting cell migration and proliferation. Reversal of these events using a PI3K inhibitor offers potential targeted therapies for colorectal cancer patients.
CANCER BIOLOGY & THERAPY
(2022)
Article
Medicine, Research & Experimental
Jing Dan, Ting Tan, Man Wu, Jin Gong, Qingguo Yang, Linling Wang, Ping Wang
Summary: Corneal epithelial abnormality in diabetic keratopathy is associated with delayed wound healing. The Wnt/beta-catenin signaling pathway plays a role in the development and stratification of corneal epithelial cells. This study showed downregulation of Wnt/beta-catenin signaling pathway factors in diabetic corneas. Topical treatment with lithium chloride increased the wound healing rate in diabetic mice, accompanied by upregulation of Wnt7a, beta-catenin, cyclin D1, and p-Gsk3b levels, as well as beta-catenin nuclear translocation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Sandy Winfield Jere, Heidi Abrahamse, Nicolette Nadene Houreld
Summary: Cell signalling plays a crucial role in wound healing, and dysregulation of signalling pathways can lead to chronic wounds. The interaction between the AKT and beta-catenin signalling pathways influences diabetic wound healing, and photobiomodulation can enhance this process.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Delphine Meffre, Ghjuvan'Ghjacumu Shackleford, Mehdi Hichor, Victor Gorgievski, Eleni T. Tzavara, Amalia Trousson, Abdel M. Ghoumari, Cyrille Deboux, Brahim Nait Oumesmar, Philippe Liere, Michael Schumacher, Etienne-Emile Baulieu, Frederic Charbonnier, Julien Grenier, Charbel Massaad
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Biochemistry & Molecular Biology
Ghjuvan' Ghjacumu Shackleford, Julien Grenier, Walid Abi Habib, Charbel Massaad, Delphine Meffre
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Kallia Apazoglou, Severine Farley, Victor Gorgievski, Raoul Belzeaux, Juan Pablo Lopez, Julien Grenier, El Cherif Ibrahim, Marie-Anne El Khoury, Yiu C. Tse, Raphaele Mongredien, Alexandre Barbe, Carlos E. A. de Macedo, Wojciech Jaworski, Ariane Bochereau, Alejandro Orrico, Elsa Isingrini, Chloe Guinaudie, Lenka Mikasova, Franck Louis, Sophie Gautron, Laurent Groc, Charbel Massaad, Ferah Yildirim, Vincent Vialou, Sylvie Dumas, Fabio Marti, Naguib Mechawar, Elise Morice, Tak P. Wong, Jocelyne Caboche, Gustavo Turecki, Bruno Giros, Eleni T. Tzavara
Article
Neurosciences
Gemma Llufriu-Daben, Alex Carrete, Elena Chierto, Jo Mailleux, Emeline Camand, Anne Simon, Tim Vanmierlo, Christiane Rose, Bernadette Allinquant, Jerome J. A. Hendriks, Charbel Massaad, Delphine Meffre, Mehrnaz Jafarian-Tehrani
NEUROBIOLOGY OF DISEASE
(2018)
Article
Multidisciplinary Sciences
Ghjuvan Ghjacumu Shackleford, Nirmal Kumar Sampathkumar, Mehdi Hichor, Laure Weill, Delphine Meffre, Ludmila Juricek, Ingrid Laurendeau, Aline Chevallier, Nicolas Ortonne, Frederique Larousserie, Marc Herbin, Ivan Bieche, Xavier Coumoul, Mathieu Beraneck, Etienne-Emile Baulieu, Frederic Charbonnier, Eric Pasmant, Charbel Massaad
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Mehdi Hichor, Venkat Krishnan Sundaram, Stephanie A. Eid, Ronza Abdel-Rassoul, Patrice X. Petit, Didier Borderie, Jean Bastin, Assaad A. Eid, Marin Manuel, Julien Grenier, Charbel Massaad
SCIENTIFIC REPORTS
(2018)
Article
Biochemical Research Methods
Gemma Llufriu-Daben, Delphine Meffre, Charbel Massaad, Mehrnaz Jafarian-Tehrani
JOURNAL OF NEUROSCIENCE METHODS
(2019)
Article
Multidisciplinary Sciences
Fausto Ulloa, Alba Gonzalez-Junca, Delphine Meffre, Pablo Jose Barrecheguren, Ramon Martinez-Marmol, Irene Pazos, Nuria Olive, Tiziana Cotrufo, Joan Seoane, Eduardo Soriano
Article
Neurosciences
Elena Chierto, Anne Simon, Francesca Castoldi, Delphine Meffre, Giulia Cristinziano, Francesca Sapone, Alex Carrete, Didier Borderie, Francois Etienne, Francois Rannou, Barclay Morrison, Charbel Massaad, Mehrnaz Jafarian-Tehrani
MOLECULAR NEUROBIOLOGY
(2019)
Article
Neurosciences
Alex Carrete, Aida Padilla-Ferrer, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehrani
Summary: The study demonstrates the beneficial effects of etazolate on demyelination, with modest improvement at the functional level but no significant impact on gene expression. Impaired locomotor activity was observed after CPZ intoxication, while spatial memory remained unaffected.
Article
Biochemical Research Methods
Nirmal Kumar Sampathkumar, Venkat Krishnan SundaramID, Prakroothi S. Danthi, Rasha Barakat, Shiden Solomon, Mrityunjoy Mondal, Ivo Carre, Tatiana El Jalkh, Aida Padilla-Ferrer, Julien Grenier, Charbel Massaad, Jacqueline C. Mitchell
Summary: The choice of reference genes heavily influences the assessment of differential gene expression by qPCR. Recent studies suggest using RNA-Seq to identify stable genes and statistical approaches to determine the best reference genes. However, this study demonstrates that the statistical approach to determine the best reference genes from commonly used candidates is more important than preselecting stable genes from RNA-Seq data.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leo Houdebine, Cristina Anna Gallelli, Marialetizia Rastelli, Nirmal Kumar Sampathkumar, Julien Grenier
CHEMISTRY AND PHYSICS OF LIPIDS
(2017)
Article
Biochemistry & Molecular Biology
Mehdi Hichor, Nirmal Kumar Sampathkumar, Julia Montanaro, Didier Borderie, Patrice X. Petit, Victor Gorgievski, Eleni T. Tzavara, Assaad A. Eid, Frederic Charbonnier, Julien Grenier, Charbel Massaad
ANTIOXIDANTS & REDOX SIGNALING
(2017)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.