GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism

A survey of seizures and current treatments in 15q duplication syndrome

(2014) Kerry D. Conant et al.   EPILEPSIA

Clinical and genomic evaluation of 201 patients with Phelan–McDermid syndrome

(2014) Sara M. Sarasua et al.   HUMAN GENETICS

Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests

(2014) Amy E. Clipperton-Allen et al.   HUMAN MOLECULAR GENETICS

Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala

(2014) Brandon S. Martin et al.   JOURNAL OF NEUROPHYSIOLOGY

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission

(2014) T. Karayannis et al.   NATURE

GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model

(2014) Cheryl L. Gatto et al.   NEUROBIOLOGY OF DISEASE

Enhancement of Inhibitory Neurotransmission by GABA A Receptors Having α 2,3 -Subunits Ameliorates Behavioral Deficits in a Mouse Model of Autism

(2014) Sung Han et al.   NEURON

Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation

(2014) Nadine Gogolla et al.   NEURON

Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons

(2013) Gregory B. Bissonette et al.   BEHAVIOURAL BRAIN RESEARCH

Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: Implications for autism spectrum disorders

(2013) Paola Sgadò et al.   EXPERIMENTAL NEUROLOGY

Chronic desipramine treatment rescues depression-related, social and cognitive deficits inEngrailed-2knockout mice

(2013) J. Brielmaier et al.   GENES BRAIN AND BEHAVIOR

GABA estimation in the brains of children on the autism spectrum: Measurement precision and regional cortical variation

(2013) W. Gaetz et al.   NEUROIMAGE

The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex

(2013) Stephanie M. McTighe et al.   PLoS One

Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice

(2013) Travis M Kerr et al.   Molecular Autism

Absence of social conditioned place preference in BTBR T+tf/J mice: Relevance for social motivation testing in rodent models of autism

(2012) Brandon L. Pearson et al.   BEHAVIOURAL BRAIN RESEARCH

Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2

(2012) Markus Wöhr et al.   BEHAVIOURAL BRAIN RESEARCH

Targeted treatment trials for tuberous sclerosis and autism: no longer a dream

(2012) Mustafa Sahin   CURRENT OPINION IN NEUROBIOLOGY

Analysis of the effects of rare variants on splicing identifies alterations in GABAA receptor genes in autism spectrum disorder individuals

(2012) Amélie Piton et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders

(2012) Lindsay M Oberman   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

(2012) M. Yang et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

Co-learning facilitates memory in mice: A new avenue in social neuroscience

(2012) Tatiana V. Lipina et al.   NEUROPHARMACOLOGY

AMPAKINE enhancement of social interaction in the BTBR mouse model of autism

(2012) J.L. Silverman et al.   NEUROPHARMACOLOGY

Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism

(2012) Jill L. Silverman et al.   NEUROPHARMACOLOGY

GABAA and GABAB receptors have opposite effects on synaptic glutamate release on the nucleus tractus solitarii neurons

(2012) Y.-H. Kang et al.   NEUROSCIENCE

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen

(2012) C. Henderson et al.   Science Translational Medicine

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

(2012) J. L. Silverman et al.   Science Translational Medicine

Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial

(2012) E. M. Berry-Kravis et al.   Science Translational Medicine

GABAB-mediated rescue of altered excitatory–inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction

(2012) M J Gandal et al.   Translational Psychiatry

Deconstructing Sociability, An Autism-Relevant Phenotype, in Mouse Models

(2011) Andrew H. Fairless et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications

(2011) Gene J. Blatt et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors

(2011) Dionisio A. Amodeo et al.   BEHAVIOURAL BRAIN RESEARCH

Evaluation of the GABAergic nervous system in autistic brain: 123I-iomazenil SPECT study

(2011) Tatsuo Mori et al.   BRAIN & DEVELOPMENT

Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits

(2011) Olga Peñagarikano et al.   CELL

Impaired inhibitory control of cortical synchronization in fragile X syndrome

(2011) Scott M. Paluszkiewicz et al.   JOURNAL OF NEUROPHYSIOLOGY

Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

(2011) Alexia M. Thomas et al.   PSYCHOPHARMACOLOGY

Autism: A “Critical Period” Disorder?

(2011) Jocelyn J. LeBlanc et al.   NEURAL PLASTICITY

Expression of social behaviors of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system

(2010) Roger L.H. Pobbe et al.   BEHAVIOURAL BRAIN RESEARCH

General and social anxiety in the BTBR T+ tf/J mouse strain

(2010) Roger L.H. Pobbe et al.   BEHAVIOURAL BRAIN RESEARCH

A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice

(2010) Erwin B. Defensor et al.   BEHAVIOURAL BRAIN RESEARCH

Sociability and motor functions in Shank1 mutant mice

(2010) Jill L. Silverman et al.   BRAIN RESEARCH

Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism

(2010) B. L. Pearson et al.   GENES BRAIN AND BEHAVIOR

Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior

(2010) Georgianna G. Gould et al.   JOURNAL OF NEUROCHEMISTRY

Defective GABAergic Neurotransmission and Pharmacological Rescue of Neuronal Hyperexcitability in the Amygdala in a Mouse Model of Fragile X Syndrome

(2010) J. L. Olmos-Serrano et al.   JOURNAL OF NEUROSCIENCE

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes

(2010) K.L. Eagleson et al.   NEUROSCIENCE

Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism

(2010) Kathryn K. Chadman   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

(2010) Randi Hagerman et al.   Molecular Autism

Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study

(2009) Jane Yip et al.   Autism Research

Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain

(2009) Bryce C. Ryan et al.   BEHAVIOURAL BRAIN RESEARCH

A synaptic trek to autism

(2009) Thomas Bourgeron   CURRENT OPINION IN NEUROBIOLOGY

Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size

(2009) M. Shinawi et al.   JOURNAL OF MEDICAL GENETICS

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

(2009) Nadine Gogolla et al.   Journal of Neurodevelopmental Disorders

Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

(2009) Jill L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Increased susceptibility to kainic acid–induced seizures in Engrailed-2 knockout mice

(2009) P.P. Tripathi et al.   NEUROSCIENCE

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

(2009) Alexia Thomas et al.   PSYCHOPHARMACOLOGY

Transmission disequilibrium testing of the chromosome 15q11-q13 region in autism

(2008) Soo-Jeong Kim et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice

(2008) Kathryn K. Chadman et al.   Autism Research

Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism

(2008) Maria Luisa Scattoni et al.   PLoS One

Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: A potential model of autism spectrum disorder

(2007) T DELOREY et al.   BEHAVIOURAL BRAIN RESEARCH

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR