Article
Neurosciences
Ayaka Osada, Suzuro Hitomi, Akira Nakajima, Yoshinori Hayashi, Ikuko Shibuta, Yoshiyuki Tsuboi, Mitsuru Motoyoshi, Koichi Iwata, Masamichi Shinoda
Summary: Tooth movements during orthodontic treatment often result in tooth pain. This study found that periodontal acidification caused by tooth movement plays a significant role in mechanical tooth pain hypersensitivity.
NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Xinyu Yan, Han Han, Shizhen Zhang, Yanzhu Lu, Linghuan Ren, Yufei Tang, Xiaolong Li, Fan Jian, Yan Wang, Hu Long, Wenli Lai
Summary: The study found that N/OFQ can exacerbate orofacial pain and upregulate the expression of CGRP in the trigeminal ganglia, while UFP-101 can alleviate pain and downregulate the expression of CGRP. Gene therapy based on overexpression of N/OFQ was successful in exacerbating pain and elevating CGRP expression in the trigeminal ganglia.
Article
Clinical Neurology
Rui Guo, Yiyin Chen, Lu Liu, Jing Wen, Hong Yang, Yafen Zhu, Meiya Gao, Hengyan Liang, Wenli Lai, Hu Long
Summary: NGF plays an important role in regulating orofacial pain by positively regulating CCL19 expression in the trigeminal ganglia of rats, while CCL19 increases sensitivity to experimental tooth movement orofacial pain.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Changyun Sun, Mila Janjic Rankovic, Matthias Folwaczny, Sven Otto, Andrea Wichelhaus, Uwe Baumert
Summary: This systematic review summarizes the role of hPDLCs in mechanosensing and mechanotransduction during orthodontic tooth movement, as well as the effects of tension application on genes, proteins, and metabolites, along with the identification of signaling pathways involved. It provides important insights for future research in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Clinical Neurology
Isabella Mai Christiansen, Jacob C. A. Edvinsson, Philip Reducha, Lars Edvinsson, Kristian Agmund Haanes
Summary: The present study demonstrates that ACEA alone does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Biochemistry & Molecular Biology
Hiroyuki Inoue, Hidetaka Kuroda, Wataru Ofusa, Sadao Oyama, Maki Kimura, Tatsuya Ichinohe, Yoshiyuki Shibukawa
Summary: The ionotropic P2X receptor P2X(7) is believed to play a role in regulating and generating nociceptive pain in neuropathological diseases. Detailed examination of its functional properties in trigeminal ganglion (TG) neurons revealed that P2X(7) may interact with other P2X receptors and pannexin-1 (PANX1) channels to influence pain sensing pathways through autocrine or paracrine signaling. The complex formed by P2X(7)-PANX1-P2X receptor/channel may be involved in long-lasting neuronal activity driven by extracellular high-concentration ATP following tissue damage in the orofacial area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Birgit Vogler, Annette Kuhn, Kimberly D. Mackenzie, Jennifer Stratton, Maria Dux, Karl Messlinger
Summary: Treatment with anti-CGRP antibody fremanezumab effectively prevents chronic and frequent episodic migraines by reducing CGRP release and aversive behavior in rats. Immunohistochemistry and ELISA techniques revealed that fremanezumab treatment significantly lowers the presence of CGRP and CGRP receptor components in the trigeminal ganglion. This reduction in CGRP receptors may contribute to the pain-relieving effects of monoclonal anti-CGRP antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Sagar S. S. Bhat, Ameet Vaman Revankar, Roopak D. D. Naik
Summary: This study aimed to evaluate the presence and concentration of salivary molecular pain biomarkers CGRP and BDNF during initial stages of orthodontic treatment and their correlation with subjective pain scales. The results showed that BDNF correlated with all subjective pain scales, indicating the need for further investigation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Tianjin Tao, Yi Liu, Jingqi Zhang, Wenli Lai, Hu Long
Summary: The nerve growth factor (NGF) and calcitonin gene-related peptide (CGRP) play a crucial role in the regulation of orofacial pain. This study found that ATPase subunit 1 is involved in vesicular transport in neurons and regulates orofacial pain by influencing the expression and release of CGRP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Francesca Bonomini, Gaia Favero, Stefania Castrezzati, Elisa Borsani
Summary: Orofacial pain is a complex biomedical challenge without a satisfactory solution. This review evaluates the involvement of neurotrophins in orofacial nociception and their potential role as targets for pain modulation. Further studies are needed to clarify their application in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Arief Waskitho, Yumiko Yamamoto, Swarnalakshmi Raman, Fumiya Kano, Huijiao Yan, Resmi Raju, Shaista Afroz, Tsuyoshi Morita, Daisuke Ikutame, Kazuo Okura, Masamitsu Oshima, Akihito Yamamoto, Otto Baba, Yoshizo Matsuka
Summary: BoNT/A reduces neurotransmitter release to alleviate neuropathic pain and may exert therapeutic effects through axonal and hematogenous transport.
Article
Biochemistry & Molecular Biology
Natsuki Saito, Maki Kimura, Takehito Ouchi, Tatsuya Ichinohe, Yoshiyuki Shibukawa
Summary: An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains unclear. This study found that CGRP and cAMP signaling negatively regulate dentinogenesis in odontoblasts and establish an axon reflex in the dental pulp via intercellular communication between trigeminal ganglion neurons and odontoblasts.
Article
Neurosciences
K. C. Elina, Jaisan Islam, Soochong Kim, Hyong Kyu Kim, Young Seok Park
Summary: Inhibiting TG through optogenetics can reduce neuronal activity and pain behavior in TN rats, indicating its potential as a management approach for trigeminal neuralgia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Aida Maddahi, Karin Warfvinge, Anja Holm, Jacob C. A. Edvinsson, Philip Victor Reducha, Spyridoula Kazantzi, Kristian A. Haanes, Lars Edvinsson
Summary: This study investigated the distribution of progesterone in the trigeminovascular system and its role in modulating sensory neurotransmission. The results suggest that progesterone may modulate sensory neurotransmission and vascular responses in a complex manner, with effects varying by sex, tissue type, and the nature of the stimulus. Further research is needed to fully understand the underlying mechanisms and physiological implications of these findings.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Clinical Neurology
R. Giniatullin, A. Nistri
Summary: Migraine is a widespread health burden with a complex pathophysiology. This article focuses on the role of ATP and P2X3 receptors in activating trigeminal nociceptive neurons and inducing migraine headache. Understanding these mechanisms can potentially lead to innovative treatments for migraine pain.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Dentistry, Oral Surgery & Medicine
Meiya Gao, Xinyu Yan, Rui Zhao, Yue Shan, Yiyin Chen, Fan Jian, Hu Long, Wenli Lai
Summary: This study compared pain perception, anxiety, and impacts on oral health-related quality of life between adult patients receiving clear aligners and fixed appliances during the initial stage of orthodontic treatments. Patients treated with clear aligners experienced lower pain levels, less anxiety, and higher OHRQoL compared to those receiving fixed appliances.
EUROPEAN JOURNAL OF ORTHODONTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
H. Liang, H. Hu, D. Shan, J. Lyu, X. Yan, Y. Wang, F. Jian, X. Li, W. Lai, H. Long
Summary: CGRP is upregulated in trigeminal neurons and SGCs following orofacial pain induction. Knockdown of CGRP reduces pain and its expression in neurons and SGCs. CGRP upregulates inducible nitric oxide synthase in SGCs through p38 signaling pathway, leading to a positive-feedback neuron-glia crosstalk mediated by CGRP.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
Lu Liu, Qi Zhan, Jing Zhou, Qianyun Kuang, Xinyu Yan, Xiaoqi Zhang, Yue Shan, Wenli Lai, Hu Long
Summary: This study compared the effects of Forsus appliances with and without temporary anchorage devices (TADs) for patients with skeletal Class II malocclusion. The results showed that TADs, especially miniplates, were able to eliminate the dental adverse effects of Forsus appliances for the correction of skeletal Class II malocclusion.
ANGLE ORTHODONTIST
(2021)
Article
Neurosciences
Feifei Zhang, Fei Li, Hong Yang, Yu Jin, Wenli Lai, Neil Roberts, Zhiyun Jia, Qiyong Gong
Summary: This study found that orthodontic pain leads to alterations in functional connectivity within networks relevant to pain processing, which may be mediated by a white matter network related to emotion perception and cognitive processing.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Rui Zhao, Huimin Hu, Yan Wang, Wenli Lai, Fan Jian
Summary: The systematic review and meta-analysis concluded that the additional use of probiotics did not improve the efficacy of mechanical debridement (MD) in treating peri-implant mucositis (PiM) in terms of clinical and microbial outcomes in the short term.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Di Shan, Yuwei He, Meiya Gao, He Liu, Yafen Zhu, Lina Liao, Farnaz Hadaegh, Hu Long, Wenli Lai
Summary: The study found that resin infiltration and microabrasion are similarly effective in reducing the sizes of white spot lesions, but resin infiltration has an esthetic advantage over microabrasion.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lu Liu, Qinxuan Song, Jing Zhou, Qianyun Kuang, Xinyu Yan, Xiaoqi Zhang, Yue Shan, Xiaolong Li, Hu Long, Wenli Lai
Summary: This study analyzed the effects of aligner overtreatment on torque control and incisor intrusion during anterior retraction. The results showed that clear aligner therapy caused lingual tipping, extrusion, and intrusion of teeth. Canine attachments enhanced these effects and required more support from posterior teeth. Appropriate overtreatment with attachments can achieve incisor intrusion and palatal root torquing.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Cell Biology
Qingxuan Wang, Jing Xie, Chenchen Zhou, Wenli Lai
Summary: The stiffness of the substrate plays a crucial role in osteoclast differentiation and function, with higher stiffness accelerating osteoclast formation and activity. Higher stiffness substrates can also activate cytoskeletal adhesion molecules and biochemical signaling cascades.
CELL PROLIFERATION
(2022)
Review
Dentistry, Oral Surgery & Medicine
Ziwei Tang, Jiawei Zhou, Hu Long, Yanzi Gao, Qingxuan Wang, Xiaolong Li, Yan Wang, Wenli Lai, Fan Jian
Summary: This article aims to explore the mechanisms and treatments of orthodontic pain, with the hope of providing insights for future pain relief in orthodontic treatment.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Medicine, General & Internal
Shizhen Zhang, Xiaoyu Wei, Lufei Wang, Zhouqiang Wu, Lu Liu, Xinyu Yan, Wenli Lai, Hu Long
Summary: This study evaluated the bone thickness and determined the optimal sites for orthodontic mini implant insertion in the mandibular symphysis. The results showed that the bone thickness was influenced by facial types and insertion locations, heights, and angles.
Article
Medicine, General & Internal
Jing Zhou, Hong Zhou, Lingling Pu, Yanzi Gao, Ziwei Tang, Yi Yang, Meng You, Zheng Yang, Wenli Lai, Hu Long
Summary: The study aimed to develop an AI system for automatically determining CVM status, and found that the AI system showed good agreement with human examiners in terms of labelling error. Additionally, the AI system demonstrated good accuracy in CVM staging and achieved high F1 scores, indicating its reliability and usefulness in evaluating cervical vertebral maturation.
Article
Neurosciences
Feifei Zhang, Fei Li, Hong Yang, Yu Jin, Wenli Lai, Graham J. Kemp, Zhiyun Jia, Qiyong Gong
Summary: This study found that brain functional networks retain small-world organization during orthodontic pain stimulation. The nodal centrality of ipsilateral brain nodes to the pain stimulus was enhanced, while the centrality of contralateral brain areas was decreased. Furthermore, anxiety mediated the relationship between nodal efficiency of the mid-cingulate cortex and pain severity.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lingling Pu, Jing Zhou, Xinyu Yan, Hong Zhou, Xian Liu, Zheng Yang, Chengge Hua, Liang Zhang, Wenli Lai, Hu Long
Summary: The orthodontic technique using a miniscrew-anchored cantilever spring proved to be effective in substituting deeply impacted third molars for second molars with severe root resorption, achieving successful treatment outcomes that satisfied the patient.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhouqiang Wu, Xiaolei Gao, Hu Long, Wenli Lai
Summary: This study quantified facial asymmetry using 3D technology and compared it with evaluations by non-experts. The results showed that the chin and lateral mandible areas significantly contribute to facial symmetry, confirming the reliability of 3D technology in objectively measuring facial symmetry.
Article
Computer Science, Artificial Intelligence
Ke Zou, Tianjin Tao, Xuedong Yuan, Xiaojing Shen, Wenli Lai, Hu Long
Summary: In this study, an Interactive Dual-Branch Network (IDBNet) is proposed for automatic and accurate segmentation of the hard palate in the oral cavity. The IDBNet utilizes a dual-branch encoder-decoder, a channel map interaction module, and a guide map interaction module to effectively handle the diversity of hard palate shapes and intensity variations in different regions. Experimental results on an in-house dataset demonstrate the superior performance of the IDBNet method for hard palate segmentation.
APPLIED SOFT COMPUTING
(2022)
Article
Endocrinology & Metabolism
Andreia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Hinio Araijo de Castro, Anamelia Lorenzetti Bocca, Marcia Renata Mortari
Summary: This study synthesized three bioinspired peptides based on fraternine and tested their effects in a Parkinson's disease model. The peptides fra-10 and fra-14 improved motor coordination, but most of the peptides were toxic at the applied doses. All three peptides reduced the intensity of lesion-induced rotations. The peptide fra-24 increased the number of TH+ neurons in the substantia nigra and reduced the concentration of the cytokine TNF-alpha, suggesting it has neuroprotective effects in Parkinson's disease.
