Article
Biochemistry & Molecular Biology
Noe Quittot, Mathilde Fortier, Margaryta Babych, Phuong Trang Nguyen, Mathew Sebastiao, Steve Bourgault
Summary: The study reveals that GAGs exacerbate IAPP-induced cytotoxicity and membrane perturbation, increasing the local concentration of IAPP on the cell surface and promoting lipid bilayer disturbance and cell death.
Article
Biochemistry & Molecular Biology
Ye Wang, Joakim Bergstrom, Martin Ingelsson, Gunilla T. T. Westermark
Summary: This study investigates the interaction between alpha-synuclein (aSyn) and islet amyloid polypeptide (IAPP) in Alzheimer's disease and type 2 diabetes. The results show intracellular co-localization of aSyn with IAPP, but aSyn is absent in the extracellular amyloid deposits. In vitro experiments demonstrate that preformed aSyn fibrils can seed IAPP fibril formation, but IAPP does not affect aSyn fibrillation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Cell Biology
Sofia Ferreira, Ana F. Raimundo, Regina Menezes, Ivo C. Martins
Summary: This study discusses the association of IAPP with diabetes, Aβ, and dementia, elucidating the pathological role of IAPP in AD. Research has shown that IAPP not only contributes to cognitive decline, but also harms the blood-brain barrier, interacts directly with Aβ, and co-deposits with it, leading to diabetes-associated dementia.
NEURAL REGENERATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Joseph J. Castillo, Alfred C. Aplin, Daryl J. Hackney, Meghan F. Hogan, Nathalie Esser, Andrew T. Templin, Rehana Akter, Steven E. Kahn, Daniel P. Raleigh, Sakeneh Zraika, Rebecca L. Hull
Summary: The study found that aggregation of IAPP is toxic to islet endothelial cells and induces inflammatory responses, resulting in decreased capillary density, increased capillary diameter, and an increased number of pericytes.
Review
Cell Biology
Carine Marmentini, Renato C. S. Branco, Antonio C. Boschero, Mirian A. Kurauti
Summary: Islet amyloid polypeptide is a hormone co-secreted with insulin by pancreatic beta-cells and is found in patients with type 2 diabetes. Investigating aspects related to amyloid formation is crucial for developing strategies towards beta-cell protection. Approaches to prevent islet amyloid cytotoxicity have shown promise in improving beta-cell function and preventing hyperglycemia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere
Summary: Loss of IAPP signaling may not increase the risk of pancreatic cancer in individuals with diabetes.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Angelina S. Bortoletto, Ronald J. Parchem
Summary: Patients with type 2 diabetes mellitus have a significantly higher risk of developing dementia, possibly due to increased secretion of amylin. This review summarizes the mechanisms by which amylin accumulation may cause neuronal damage and discusses the importance of investigating new therapeutic targets for treating dementia.
NEURAL REGENERATION RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Yujuan Cao, Zhenyan He, Yuting Gao, Yanru Xin, Liang Luo, Fanling Meng
Summary: In this study, a bait-hook-devastate strategy was developed to improve the efficiency of photodynamic degradation of amyloid aggregates by utilizing electronic interactions to accumulate aggregates and photosensitizer in a confined area. The strategy significantly enhanced the utilization rate of generated ROS and ability to dissociate the aggregates, resulting in rapid and complete degradation of amyloid aggregates under mild conditions. This new paradigm offers a potential solution for accelerating photodynamic degradation of amyloid aggregates for practical applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Luiz E. M. Cardoso, Thatiany Souza Marinho, Fabiane Ferreira Martins, Marcia Barbosa Aguila, Carlos A. Mandarim-de-Lacerda
Summary: In this study, the effects of a glucagon-like peptide type 1 receptor agonist, semaglutide, on the turnover of islet extracellular matrix (ECM) components in an obese mouse model were investigated. The results showed that semaglutide improved the turnover of ECM components and reduced the formation of amyloid deposits.
Article
Biochemistry & Molecular Biology
Giovanna Lucia Delogu, Benedetta Era, Sonia Floris, Rosaria Medda, Valeria Sogos, Francesca Pintus, Gianluca Gatto, Amit Kumar, Gunilla Torstensdotter Westermark, Antonella Fais
Summary: The study found that hydroxylated 2-phenylbenzofurans compounds exhibited strong inhibitory activity against alpha-glucosidase, with compound 16 showing the best performance. It also effectively inhibited IAPP aggregation without significant cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Raliat O. Abioye, Chibuike C. Udenigwe
Summary: IAPP aggregation plays a crucial role in the development of type 2 diabetes by reducing insulin production and damaging pancreatic beta-cell function. Understanding the structure, function, aggregation mechanism, and inhibitors of IAPP provides insights for better management of T2D.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Food Science & Technology
Kejie Shen, Jie Long, Xingfei Li, Yufei Hua, Yeming Chen, Xiangzhen Kong, Caimeng Zhang
Summary: This study successfully improved the emulsifying property of pea protein isolate under acidic conditions by complexation with dextran sulphate.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucie Khemtemourian, Hebah Fatafta, Benoit Davion, Sophie Lecomte, Sabine Castano, Birgit Strodel
Summary: This study investigates the molecular details of IAPP binding to lipid membranes, revealing different membrane interaction modes and aggregation structures for different IAPP variants. Residue 18 plays a decisive role in the structure and membrane interaction of IAPP, making it a potential therapeutic target for inhibiting IAPP toxicity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Neurosciences
Ying-Ying Yang, Yan-Tao Ren, Meng -Yu Jia, Chen-Yang Bai, Xiu-Ting Liang, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Chuang Guo
Summary: Recent evidence suggests that human islet amyloid polypeptide (h-IAPP) may interact with A β or tau in Alzheimer's disease (AD) and have a potential therapeutic effect on neurodegenerative disorders with tauopathy, such as AD. Long-term h-IAPP treatment attenuated tau hyperphosphorylation levels, induced neuroinflammation and oxidative damage, prevented synaptic loss and neuronal degeneration, and alleviated behavioral deficits in a mouse model of tauopathy.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong, Zhentao Zhang
Summary: The study shows that IAPP interacts with tau and accelerates the formation of a more toxic strain, playing a crucial role in tau pathology in AD. Injection of IAPP-tau strain and IAPP fibrils can induce more severe tau pathology spreading and cognitive impairments.
MOLECULAR NEURODEGENERATION
(2022)