Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease

(2016) P. Hemachandra Reddy   CNS SPECTRUMS

Mitochondrial ROS metabolism: 10 Years later

(2015) A. Y. Andreyev et al.   BIOCHEMISTRY-MOSCOW

Mitochondrial DNA mutations in neurodegeneration

(2015) Michael J. Keogh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Dietary restriction, mitochondrial function and aging: from yeast to humans

(2015) Andrea Ruetenik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fndc5overexpression facilitated neural differentiation of mouse embryonic stem cells

(2015) Mahboobeh Forouzanfar et al.   CELL BIOLOGY INTERNATIONAL

Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

(2015) Liang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of mitochondrial transport in neurons

(2015) Mei-Yao Lin et al.   EXPERIMENTAL CELL RESEARCH

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

(2015) Josep A. Villena   FEBS Journal

Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues

(2015) Fatemeh Ahmadi Ghahrizjani et al.   GENE

Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning

(2015) Anne Petzold et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

(2015) Antonio Zorzano et al.   Frontiers in Aging Neuroscience

Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species

(2015) Ryan J. Mailloux   Redox Biology

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications

(2014) Dale Edmondson   CURRENT PHARMACEUTICAL DESIGN

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells

(2014) Farzaneh Rabiee et al.   GENE

Striatal metabolism and psychomotor speed as predictors of motor onset in Huntington’s disease

(2014) Meike Herben-Dekker et al.   JOURNAL OF NEUROLOGY

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

(2014) Juan Carlos Corona et al.   NEUROCHEMICAL RESEARCH

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

(2014) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling

(2014) Cristy Phillips et al.   Frontiers in Cellular Neuroscience

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

(2014) Giuseppina Amadoro et al.   Frontiers in Aging Neuroscience

Sources of superoxide/H2O2 during mitochondrial proline oxidation

(2014) Renata L.S. Goncalves et al.   Redox Biology

Mitochondrial Homeostasis Molecules: Regulation by a Trio of Recessive Parkinson's Disease Genes

(2014) Ji-Young Han et al.   Experimental Neurobiology

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

(2013) Vassilios N. Kotiadis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

(2013) Ruishan Wang et al.   Cell Metabolism

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease

(2013) B. M. Spiegelman   DIABETES

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

(2013) Sarah Ciccone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin-immunoreactivity in neural and non-neural cells of the rodent

(2013) S.L. Dun et al.   NEUROSCIENCE

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

(2013) Suna Aydin et al.   PEPTIDES

Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease

(2013) Carmela Giampà et al.   PLoS One

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

Mitochondrial disorders: aetiologies, models systems, and candidate therapies

(2013) G. Jane Farrar et al.   TRENDS IN GENETICS

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

(2013) Steffany A. L. Bennett et al.   Frontiers in Physiology

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

(2013) Jean-François Trempe et al.   Frontiers in Neurology

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Irisin and FNDC5 in retrospect

(2013) Harold P Erickson   Adipocyte

Functions of plasmalogen lipids in health and disease

(2012) Nancy E. Braverman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response

(2012) Timothy E. Shutt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

(2012) Mark P. Mattson   Cell Metabolism

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

(2012) M.-S. Hashemi et al.   NEUROSCIENCE

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Peroxisomal alterations in Alzheimer’s disease

(2011) Jianqiu Kou et al.   ACTA NEUROPATHOLOGICA

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association of PGC-1alphapolymorphisms with age of onset and risk of Parkinson's disease

(2011) Joanne Clark et al.   BMC Medical Genetics

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkin' control: regulation of PGC-1  through PARIS in Parkinson's disease

(2011) J. I. Castillo-Quan   Disease Models & Mechanisms

Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter

(2011) Elodie Martin et al.   HUMAN MOLECULAR GENETICS

Energy deficit in Huntington disease: why it matters

(2011) Fanny Mochel et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Running is the neurogenic and neurotrophic stimulus in environmental enrichment

(2011) T. Kobilo et al.   LEARNING & MEMORY

Cheaper, Simpler, and Better: Tips for Treating Seniors With Parkinson Disease

(2011) J. Eric Ahlskog   MAYO CLINIC PROCEEDINGS

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

(2011) Lillian J. Eichner et al.   MITOCHONDRION

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

(2011) Oksana Ivashchenko et al.   MOLECULAR BIOLOGY OF THE CELL

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

(2011) Wei Zhao et al.   Molecular Neurodegeneration

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

(2011) D A Rossignol et al.   MOLECULAR PSYCHIATRY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences

(2011) Ivaylo P. Ivanov et al.   NUCLEIC ACIDS RESEARCH

Nerve Growth Factor as a Signaling Molecule for Nerve Cells and also for the Neuroendocrine-Immune Systems

(2011) Marco Fiore et al.   REVIEWS IN THE NEUROSCIENCES

Oxidative Stress and Energy Crises in Neuronal Dysfunction

(2010) David G. Nicholls   Annals of the New York Academy of Sciences

The expression of peroxisomal protein transcripts increased by retinoic acid during neural differentiation☆

(2010) Maryam Ostadsharif et al.   DIFFERENTIATION

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

(2010) Youngnam N. Jin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

(2010) Maarten E. Witte et al.   MITOCHONDRION

Alzheimer's disease: Effects of β-amyloid on mitochondria

(2010) Laurent Tillement et al.   MITOCHONDRION

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

(2010) N. Volakakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

Therapeutic prospects for mitochondrial disease

(2010) Eric A. Schon et al.   TRENDS IN MOLECULAR MEDICINE

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

Brain-derived neurotrophic factor: role in depression and suicide

(2010) Yogesh Dwivedi   Neuropsychiatric Disease and Treatment

Role of the Mitochondrion in Programmed Necrosis

(2010) Christopher P. Baines   Frontiers in Physiology

Peroxisomes Are Oxidative Organelles

(2009) Vasily D. Antonenkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Multifaceted deaths orchestrated by mitochondria in neurones

(2009) Phillip Nagley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The pathophysiology of mitochondrial disease as modeled in the mouse

(2009) D. C. Wallace et al.   GENES & DEVELOPMENT

PGC-1α activation as a therapeutic approach in mitochondrial disease

(2009) Tina Wenz   IUBMB LIFE

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

The gene coding for PGC-1α modifies age at onset in Huntington's Disease

(2009) Patrick Weydt et al.   Molecular Neurodegeneration

Peroxisomes, Myelination, and Axonal Integrity in the CNS

(2009) Myriam Baes et al.   NEUROSCIENTIST

The biology of PGC-1α and its therapeutic potential

(2009) Christoph Handschin   TRENDS IN PHARMACOLOGICAL SCIENCES

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Therapeutic role of sirtuins in neurodegenerative disease

(2008) Tiago Fleming Outeiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS

The in-depth evaluation of suspected mitochondrial disease

(2008) Richard H. Haas et al.   MOLECULAR GENETICS AND METABOLISM

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS