Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy

DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different

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High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial – Background, Aims, and Study Protocol

(2018) Sandra E. Juul et al.   Neonatology

Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

(2017) Claire Thornton et al.   FEBS LETTERS

How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep?

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Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

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Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes

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Cell Death in the Developing Brain after Hypoxia-Ischemia

(2017) Claire Thornton et al.   Frontiers in Cellular Neuroscience

Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy

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Neonatal Encephalopathy

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Hypothermia and Rewarming Activate a Macroglial Unfolded Protein Response Independent of Hypoxic-Ischemic Brain Injury in Neonatal Piglets

(2016) Jennifer K. Lee et al.   DEVELOPMENTAL NEUROSCIENCE

Optimizing Cerebral Autoregulation May Decrease Neonatal Regional Hypoxic-Ischemic Brain Injury

(2016) Jennifer K. Lee et al.   DEVELOPMENTAL NEUROSCIENCE

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial

(2016) Denis Azzopardi et al.   LANCET NEUROLOGY

Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia

(2016) Kevin D. Broad et al.   NEUROBIOLOGY OF DISEASE

White matter apoptosis is increased by delayed hypothermia and rewarming in a neonatal piglet model of hypoxic ischemic encephalopathy

(2016) B. Wang et al.   NEUROSCIENCE

Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model

(2016) Eridan Rocha-Ferreira et al.   Oxidative Medicine and Cellular Longevity

Extending the duration of hypothermia does not further improve white matter protection after ischemia in term-equivalent fetal sheep

(2016) Joanne O. Davidson et al.   Scientific Reports

Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

(2015) Kyle M. Schachtschneider et al.   BMC GENOMICS

Additive Neuroprotection of a 20-HETE Inhibitor with Delayed Therapeutic Hypothermia after Hypoxia-Ischemia in Neonatal Piglets

(2015) Junchao Zhu et al.   DEVELOPMENTAL NEUROSCIENCE

Rewarming from Therapeutic Hypothermia Induces Cortical Neuron Apoptosis in a Swine Model of Neonatal Hypoxic–Ischemic Encephalopathy

(2015) Bing Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter

(2015) Mojgan Ezzati et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

How Long is Too Long for Cerebral Cooling after Ischemia in Fetal Sheep?

(2015) Joanne O Davidson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modeling Ischemia in the Immature Brain

(2015) Carina Mallard et al.   STROKE

The Domestic Piglet: An Important Model for Investigating the Neurodevelopmental Consequences of Early Life Insults

(2015) Matthew S. Conrad et al.   Annual Review of Animal Biosciences

Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury

(2014) A. Tekes et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo

(2014) Karina Wegleiter et al.   EXPERIMENTAL NEUROLOGY

Correlation Between Clinical and Histologic Findings in the Human Neonatal Hippocampus After Perinatal Asphyxia

(2014) Irene A.M. Schiering et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes

(2014) Denis Azzopardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Connexin Hemichannel Blockade Is Neuroprotective after Asphyxia in Preterm Fetal Sheep

(2014) Joanne O. Davidson et al.   PLoS One

Erythropoietin and Cancer: The Unintended Consequences of Anemia Correction

(2014) NataÅ¡a Debeljak et al.   Frontiers in Immunology

Etiology of impaired selective motor control: emerging evidence and its implications for research and treatment in cerebral palsy

(2013) Katelyn Cahill-Rowley et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Concurrent Erythropoietin and Hypothermia Treatment Improve Outcomes in a Term Nonhuman Primate Model of Perinatal Asphyxia

(2013) Christopher M. Traudt et al.   DEVELOPMENTAL NEUROSCIENCE

Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep

(2013) J.O. Davidson et al.   EXPERIMENTAL NEUROLOGY

Adenosine A2A Receptor Contributes to Ischemic Brain Damage in Newborn Piglet

(2013) Zeng-Jin Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Time Is Brain: Starting Therapeutic Hypothermia within Three Hours after Birth Improves Motor Outcome in Asphyxiated Newborns

(2013) Marianne Thoresen et al.   Neonatology

Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors

(2013) M. Ruth Pazos et al.   NEUROPHARMACOLOGY

Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic–ischemic encephalopathy

(2013) Jessica A. Howlett et al.   PEDIATRIC RESEARCH

Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures

(2012) Marija Renic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model

(2012) N. J. Robertson et al.   BRAIN

Brain Growth of the Domestic Pig(Sus scrofa)from 2 to 24 Weeks of Age: A Longitudinal MRI Study

(2012) Matthew S. Conrad et al.   DEVELOPMENTAL NEUROSCIENCE

Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model

(2012) Nicola J. Robertson et al.   JOURNAL OF NEUROCHEMISTRY

Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor

(2012) Zeng-Jin Yang et al.   JOURNAL OF NEUROCHEMISTRY

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

(2012) Stephen A. Back et al.   Neurotherapeutics

Childhood Outcomes after Hypothermia for Neonatal Encephalopathy

(2012) Seetha Shankaran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonadditive Neuroprotection With Early Glutamate Receptor Blockade and Delayed Hypothermia After Asphyxia in Preterm Fetal Sheep

(2012) Sherly A. George et al.   STROKE

Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury

(2011) Art Riddle et al.   ANNALS OF NEUROLOGY

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia

(2011) Stuart Faulkner et al.   ANNALS OF NEUROLOGY

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

(2011) Joshua R. Buser et al.   ANNALS OF NEUROLOGY

Striatal Neuroprotection from Neonatal Hypoxia-Ischemia in Piglets by Antioxidant Treatment with EUK-134 or Edaravone

(2011) Xinli Ni et al.   DEVELOPMENTAL NEUROSCIENCE

General Movements in Full-Term Infants with Perinatal Asphyxia Are Related to Basal Ganglia and Thalamic Lesions

(2011) Fabrizio Ferrari et al.   JOURNAL OF PEDIATRICS

The primate reticulospinal tract, hand function and functional recovery

(2011) Stuart N. Baker   JOURNAL OF PHYSIOLOGY-LONDON

Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia–ischemia in newborn piglet striatum

(2011) Zeng-Jin Yang et al.   NEUROBIOLOGY OF DISEASE

Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs

(2011) Hector Lafuente et al.   PEDIATRIC RESEARCH

Differential Susceptibility to Axonopathy in Necrotic and Non-Necrotic Perinatal White Matter Injury

(2011) Art Riddle et al.   STROKE

Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs

(2010) Elavazhagan Chakkarapani et al.   ANNALS OF NEUROLOGY

Epidemiology of neonatal encephalopathy and hypoxic–ischaemic encephalopathy

(2010) Jennifer J. Kurinczuk et al.   EARLY HUMAN DEVELOPMENT

Onset of pulmonary ventilation in fetal sheep produces pial arteriolar constriction dependent on cytochrome p450 ω-hydroxylase activity

(2010) Hiroto Ohata et al.   JOURNAL OF APPLIED PHYSIOLOGY

Timing of Appearance of Late Oligodendrocyte Progenitors Coincides with Enhanced Susceptibility of Preterm Rabbit Cerebral White Matter to Hypoxia-Ischemia

(2010) Joshua R Buser et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Animal models for the assessment of novel vascular conduits

(2010) Michael J. Byrom et al.   JOURNAL OF VASCULAR SURGERY

Patterns of neonatal hypoxic–ischaemic brain injury

(2010) Linda S. de Vries et al.   NEURORADIOLOGY

Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons

(2009) Zeng-Jin Yang et al.   EXPERIMENTAL NEUROLOGY

Cooling Combined with Immediate or Delayed Xenon Inhalation Provides Equivalent Long-Term Neuroprotection after Neonatal Hypoxia—Ischemia

(2009) Marianne Thoresen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial

(2009) Mary Rutherford et al.   LANCET NEUROLOGY

Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy

(2009) Denis V. Azzopardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delayed Hypothermia as Selective Head Cooling or Whole Body Cooling Does Not Protect Brain or Body in Newborn Pig Subjected to Hypoxia-Ischemia

(2009) Mathias Karlsson et al.   PEDIATRIC RESEARCH

Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats

(2008) Kathryn M. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Spatial and temporal deficits are regionally dissociable in patients with pulvinar lesions

(2008) I. Arend et al.   BRAIN

Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia

(2008) Michael A. van der Kooij et al.   BRAIN RESEARCH REVIEWS

Effect of 20-HETE Inhibition on Infarct Volume and Cerebral Blood Flow after Transient Middle Cerebral Artery Occlusion

(2008) Marija Renic et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

(2008) Francisco J Alvarez et al.   PEDIATRIC RESEARCH

Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia

(2007) Dawn Mueller-Burke et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE