Article
Multidisciplinary Sciences
Megan M. Slough, Rong Li, Andrew S. Herbert, Gorka Lasso, Ana I. Kuehne, Stephanie R. Monticelli, Russell R. Bakken, Yanan Liu, Agnidipta Ghosh, Alicia M. Moreau, Xiankun Zeng, Felix A. Rey, Pablo Guardado-Calvo, Steven C. Almo, John M. Dye, Rohit K. Jangra, Zhongde Wang, Kartik Chandran
Summary: Protocadherin-1 (PCDH1) is identified as a critical host factor for hantaviruses, and this study maps the binding site of the viral glycoprotein complex within PCDH1. Mutations engineered at this site can protect Syrian hamsters from viral challenge. PCDH1 is confirmed as a potential target for developing interventions against hantavirus cardiopulmonary syndrome (HCPS).
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Maria Iqbal, Reza Maroofian, Busranur Cavdarli, Florence Riccardi, Michael Field, Siddharth Banka, Dalal K. Bubshait, Yun Li, Jozef Hertecant, Shahid Mahmood Baig, David Dyment, Stephanie Efthymiou, Uzma Abdullah, Ehtisham Ul Haq Makhdoom, Zafar Ali, Tobias Scherf de Almeida, Florence Molinari, Cecile Mignon-Ravix, Brigitte Chabrol, Jayne Antony, Lesley Ades, Alistair T. Pagnamenta, Adam Jackson, Sofia Douzgou, Christian Beetz, Vasiliki Karageorgou, Barbara Vona, Aboulfazl Rad, Jamshaid Mahmood Baig, Tipu Sultan, Javeria Raza Alvi, Shazia Maqbool, Fatima Rahman, Mehran Beiraghi Toosi, Farah Ashrafzadeh, Shima Imannezhad, Ehsan Ghayoor Karimiani, Yasra Sarwar, Sheraz Khan, Muhammad Jameel, Angelika A. Noegel, Birgit Budde, Janine Altmueller, Susanne Motameny, Wolfgang Hoehne, Henry Houlden, Peter Nuernberg, Bernd Wollnik, Laurent Villard, Fowzan Sami Alkuraya, Matthew Osmond, Muhammad Sajid Hussain, Gokhan Yigit
Summary: A novel autosomal recessive neurodevelopmental disorder has been defined, with biallelic disease-causing variants in Protocadherin-gamma-C4 (PCDHGC4) identified as the underlying genetic cause. This study highlights PCDHGC4 as a member of the clustered PCDH family involved in a Mendelian disorder in humans.
GENETICS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Nan He, Xiaoming Liu, Amber R. Vegter, T. Idil A. Evans, Jaimie S. Gray, Junfeng Guo, Shashanna R. Moll, Lydia J. Guo, Meihui Luo, Ningxia Ma, Xingshen Sun, Bo Liang, Ziying Yan, Zehua Feng, Lisi Qi, Arnav S. Joshi, Weam Shahin, Yaling Yi, Katherine N. Gibson-Corley, Eric A. Hoffman, Kai Wang, Christian Mueller, John F. Engelhardt, Bradley H. Rosen
Summary: Alpha-1 antitrypsin deficiency (AATD) is the most common genetic cause and risk factor for chronic obstructive pulmonary disease. This study used ferret models to demonstrate that complete loss of AAT and the most common mutation in AAT result in lung and hepatic diseases similar to those observed in AATD patients, making them a potential platform for preclinical testing of therapeutics including gene therapy.
Article
Anatomy & Morphology
Vivek Kumar, David M. Krolewski, Elaine K. Hebda-Bauer, Aram Parsegian, Brian Martin, Matthew Foltz, Huda Akil, Stanley J. Watson
Summary: By optimizing the application of in situ hybridization chain reaction in fresh-frozen rodent brains and combining with clearing methods, the uniformity of neuronal labeling can be achieved. While its application in postmortem human tissues is limited, there is a broad prospect for its use in rodent studies.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biochemistry & Molecular Biology
Meng Chen, Yuan Dong, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 promotes adipocyte differentiation by interacting with PTPRD to activate SFKs, such as FYN tyrosine kinase.
Article
Biochemistry & Molecular Biology
Yoichiro Takahashi, Kristen R. Maynard, Madhavi Tippani, Andrew E. Jaffe, Keri Martinowich, Joel E. Kleinman, Daniel R. Weinberger, Thomas M. Hyde
Summary: The study identified distinct localization patterns of schizophrenia risk transcripts in the healthy human brain, with SNX19 transcripts potentially disrupting the normal function of glutamatergic neurons and AS3MT leading to disturbances in the GABAergic system.
MOLECULAR PSYCHIATRY
(2021)
Article
Engineering, Environmental
Jing Zhou, Ruijie Fu, Haoran Liu, Yanlin Liu, Yiwen Wang, Bining Jiao, Yue He, Hongwu Tang
Summary: The study introduces a high-resolution colorimetric biosensor based on multiple hybridization chain reactions (HCRs) and gold nanoparticles (AuNP) for ultrasensitive detection of the Staphylococcus aureus (S. aureus) mecA gene. The method demonstrates high specificity and sensitivity, capable of detecting target DNA concentrations as low as 2.71 pM with rainbow-like colors associated with different DNA concentrations. This approach has potential applications in clinical diagnosis.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Clinical Neurology
Brendan Monogue, Yixi Chen, Hadrian Sparks, Ranya Behbehani, Andrew Chai, Alexander J. Rajic, Aaron Massey, B. K. Kleinschmidt-Demasters, Matthieu Vermeren, Tilo Kunath, J. David Beckham
Summary: The normal function of alpha-synuclein in neurons is not clearly defined. This study found that alpha-synuclein functions in neurons to support immune signaling by co-localizing to the nucleus with interferon signaling proteins following interferon stimulation.
Article
Neurosciences
Fabrizio Vecchio, Francesca Alu, Alessandro Orticoni, Francesca Miraglia, Elda Judica, Maria Cotelli, Paolo Maria Rossini
Summary: The brain state preceding a task can influence motor performance at the single trial level, with specific changes in EEG rhythms power spectral density correlating with faster responses during a visuomotor task. This suggests that EEG markers may be able to predict an individual's performance on a trial-by-trial basis, highlighting the potential clinical relevance of predicting brain states for rehabilitation strategies.
COGNITIVE NEURODYNAMICS
(2022)
Article
Anatomy & Morphology
Mauro Chivite, Esther Leal, Jesus M. Miguez, Jose Miguel Cerda-Reverter
Summary: This study investigated the mRNA distribution of TPH1 and TPH2 paralogues in the central nervous system of rainbow trout, revealing segregated expression patterns that align with previous immunocytochemical studies. By focusing on the central distribution of serotonergic markers, particularly TPHs, this research provides valuable insights into characterizing true serotonergic brain territories in vertebrates.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Veterinary Sciences
Lilla Denes, David G. Horvath, Oliver Duran, Poul H. Ratkhjen, Christian Kraft, Balazs Acs, Attila M. Szasz, Till Ruemenapf, Marton Papp, Andrea Ladinig, Gyula Balka
Summary: A novel RNA-based in situ hybridization technique (RNAscope) was developed to detect PRRSV RNA in lung tissues of experimentally infected animals, showing significant association with real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) test results.
VETERINARY SCIENCES
(2021)
Article
Cell Biology
Yao Jing, Lin Zhang, Shi-Wen Chen, Yan Guo, Shi-Ming Ju, Fang Yuan, Hao Chen, Dian-Xu Yang, Heng-Li Tian, Zhi-Ming Xu, Jun Ding
Summary: This study found that phosphatase actin regulatory factor 1 expression is increased in different cell types in a mouse model of traumatic brain injury. Overexpressing phosphatase actin regulatory factor 1 resulted in increased brain water content, while knocking down its expression decreased water content. Inhibiting phosphatase actin regulatory factor 1 also regulated various pathways, improving neurological function. These findings suggest that it may be a potential therapeutic target for traumatic brain injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Xiangliang Zeng, Guohua He, Xirong Yang, Guoyao Xu, Yidan Tang, Hanwen Li, Bing Yu, Zhen Wang, Wei Xu, Kangping Song
Summary: Zebularine preserves BBB integrity, reduces inflammation, and improves neurological deficits in ischemic stroke. It mitigates endothelial hyper-permeability by activating the AMPK alpha pathway.
Article
Immunology
Goo-Young Seo, Daisuke Takahashi, Qingyang Wang, Zbigniew Mikulski, Angeline Chen, Ting-Fang Chou, Paola Marcovecchio, Sara McArdle, Ashu Sethi, Jr-Wen Shui, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg
Summary: This study reveals the important role of intestinal epithelial cells and basement membrane in the survival and function of Intraepithelial T cells (IETs). The binding of the ligand LIGHT to the herpes virus entry mediator (HVEM) expressed by epithelial cells promotes the survival of IETs. Additionally, epithelial cells increase the synthesis of basement membrane protein collagen IV, which interacts with beta(1) integrins expressed by IETs. These interactions are crucial for the maintenance and protective function of IETs in mucosal immunity.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Goo-Young Seo, Daisuke Takahashi, Qingyang Wang, Zbigniew Mikulski, Angeline Chen, Ting-Fang Chou, Paola Marcovecchio, Sara McArdle, Ashu Sethi, Jr-Wen Shui, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg
Summary: This study demonstrates that HVEM and its ligands in intestinal epithelial cells can promote the survival of small intestine IETs in steady state. HVEM enhances the synthesis of basement membrane proteins by epithelial cells, supporting the survival of IETs. Lack of β(1) integrins results in decreased number and movement of IETs.
SCIENCE IMMUNOLOGY
(2022)
Article
Neurosciences
Kumar Krishna, Thomas Behnisch, Sreedharan Sajikumar
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Multidisciplinary Sciences
Ananya Dasgupta, Nimmi Baby, Kumar Krishna, Muhammad Hakim, Yuk Peng Wong, Thomas Behnisch, Tuck Wah Soong, Sreedharan Sajikumar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Laura Frangeul, Vassilis Kehayas, Jose V. Sanchez-Mut, Sabine Fievre, K. Krishna-K, Gabrielle Pouchelon, Ludovic Telley, Camilla Bellone, Anthony Holtmaat, Johannes Graff, Jeffrey D. Macklis, Denis Jabaudon
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Sarah Xinwei Luo, Ju Huang, Qin Li, Hasan Mohammad, Chun-Yao Lee, Kumar Krishna, Alison Maun-Yeng Kok, Yu Lin Tan, Joy Yi Lim, Hongyu Li, Ling Yun Yeow, Jingjing Sun, Miao He, Joanes Grandjean, Sreedharan Sajikumar, Weiping Han, Yu Fu
Article
Neurosciences
Johannes Etzrodt, K. Krishna-K, Christoph Redies
Article
Neurosciences
Krishna-K, Monique Nuernberger, Franco Weth, Christoph Redies
Article
Microbiology
Mandira Varma-Basil, Shailendra K. D. Dwivedi, Krishna Kumar, Rakesh Pathak, Ritika Rastogi, S. S. Thukral, Malini Shariff, V. K. Vijayan, Sunil K. Chhabra, Rama Chaudhary
JOURNAL OF MEDICAL MICROBIOLOGY
(2009)
Article
Neurosciences
K. Krishna-K, N. Hertel, C. Redies
Article
Clinical Neurology
Fanny Niv, Silke Keiner, Krishna-K, Otto W. Witte, Dieter Chichung Lie, Christoph Redecker
Article
Multidisciplinary Sciences
Karen Ka Lam Pang, Mahima Sharma, Kumar Krishna-K, Thomas Behnisch, Sreedharan Sajikumar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Neurosciences
Genevieve Saw, Kumar Krishna, Neelima Gupta, Tuck Wah Soong, Karthik Mallilankaraman, Sreedharan Sajikumar, S. Thameem Dheen
Article
Biology
Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikumar
Article
Biochemistry & Molecular Biology
Kumar Krishna-K, Nimmi Baby, Radha Raghuraman, Sheeja Navakkode, Thom Behnisch, Sreedharan Sajikumar
Article
Neurosciences
Kumar Krishna-K, Thomas Behnisch, Sreedharan Sajikumar
Summary: Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions, which are partly due to decreased activity-dependent synaptic plasticity. This study shows that inhibition of proteasome-mediated protein degradation can restore impaired synaptic plasticity in an AD-like mouse model. The ubiquitin-proteasome system (UPS) plays a critical role in protein turnover and synaptic function. Dysfunction of UPS is implicated in inadequate proteostasis and synaptic malfunction in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
