3D Cell Culture Systems: Advantages and Applications

AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies

(2013) Chandraiah Godugu et al.   PLoS One

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

Three-Dimensional Neuroepithelial Culture from Human Embryonic Stem Cells and Its Use for Quantitative Conversion to Retinal Pigment Epithelium

(2013) Yu Zhu et al.   PLoS One

An Efficient 3D Cell Culture Method on Biomimetic Nanostructured Grids

(2013) Maria Wolun-Cholewa et al.   PLoS One

Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

(2013) E. L. S. Fong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Enhanced Survival and Neurite Network Formation of Human Umbilical Cord Blood Neuronal Progenitors in Three-Dimensional Collagen Constructs

(2012) Marian M. Bercu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Genome-Wide Gene Expression Analysis in Cancer Cells Reveals 3D Growth to Affect ECM and Processes Associated with Cell Adhesion but Not DNA Repair

(2012) Oliver Zschenker et al.   PLoS One

Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels

(2012) Brian Fallica et al.   PLoS One

Configurable 2D and 3D spheroid tissue cultures on bioengineered surfaces with acquisition of epithelial–mesenchymal transition characteristics

(2012) Ching-Te Kuo et al.   NPG Asia Materials

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

(2011) M. Ehrbar et al.   BIOPHYSICAL JOURNAL

Stiffness of photocrosslinked RGD-alginate gels regulates adipose progenitor cell behavior

(2011) Emily M. Chandler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Three-Dimensional Culture of Mouse Renal Carcinoma Cells in Agarose Macrobeads Selects for a Subpopulation of Cells with Cancer Stem Cell or Cancer Progenitor Properties

(2011) B. H. Smith et al.   CANCER RESEARCH

Cancer Cell Migration: Integrated Roles of Matrix Mechanics and Transforming Potential

(2011) Erin L. Baker et al.   PLoS One

Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study

(2010) Danielle N. Rockwood et al.   Acta Biomaterialia

Activity of Anticancer Agents in a Three-Dimensional Cell Culture Model

(2010) Victor Sanjit Nirmalanandhan et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Directed 3D cell alignment and elongation in microengineered hydrogels

(2010) Hug Aubin et al.   BIOMATERIALS

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Stem cells in bone tissue engineering

(2010) Jeong Min Seong et al.   Biomedical Materials

3D collagen type I matrix inhibits the antimigratory effect of doxorubicin

(2010) Emilie Millerot-Serrurot et al.   Cancer Cell International

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism

(2010) Shih-Feng Lan et al.   TOXICOLOGY IN VITRO

Electrophysiological characterization of embryonic hippocampal neurons cultured in a 3D collagen hydrogel

(2009) Tao Xu et al.   BIOMATERIALS

Probing cellular mechanobiology in three-dimensional culture with collagen–agarose matrices

(2009) Theresa A. Ulrich et al.   BIOMATERIALS

Extracellular Matrix Stiffness and Architecture Govern Intracellular Rheology in Cancer

(2009) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

Biochemical properties of encapsulated high-density 3-D HepG2 aggregates formed in an ultrasound trap for application in hepatotoxicity studies

(2009) Despina Bazou   CELL BIOLOGY AND TOXICOLOGY

Differential methotrexate hepatotoxicity on rat hepatocytes in 2-D monolayer culture and 3-D gel entrapment culture

(2009) Jian Yin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Matrix mechanics and receptor–ligand interactions in cell adhesion

(2009) Dewi Harjanto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Differential Maturation and Structure–Function Relationships in Mesenchymal Stem Cell- and Chondrocyte-Seeded Hydrogels

(2009) Isaac E. Erickson et al.   TISSUE ENGINEERING PART A

Three-Dimensional Culture Alters Primary Cardiac Cell Phenotype

(2009) Robert E. Akins et al.   TISSUE ENGINEERING PART A

Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?

(2008) Giovanna Mazzoleni et al.   Genes and Nutrition

3-D Tumor Model forIn VitroEvaluation of Anticancer Drugs

(2008) Jayme L. Horning et al.   MOLECULAR PHARMACEUTICS

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE