Article
Biochemistry & Molecular Biology
Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic, Douglas R. Green
Summary: The imbalance of intracellular Ca2+ and mitochondrial Ca2+ overload can lead to mitochondrial inner membrane permeabilization and cell death, which is distinct from Bcl-2 family-regulated mitochondrial outer membrane permeabilization. Cyclosporin A can prevent cell death by inhibiting Ca2+ release from endoplasmic reticulum stores.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Giovanni Quarato, Luigi Mari, Nicholas J. Barrows, Mao Yang, Sebastian Ruehl, Mark J. Chen, Cliff S. Guy, Jonathan Low, Taosheng Chen, Douglas R. Green
Summary: The degradation of defective mitochondria is regulated by the ubiquitin-proteasome system and lysosomal activities, which play essential roles in maintaining cellular homeostasis. Activation of the PINK1-Parkin axis following mitochondrial damage triggers a BAX- and BAK-independent cytochrome c release process, leading to apoptosis mediated by APAF1 and caspase 9. This process is initiated by UPS-dependent outer mitochondrial membrane degradation and can be reversed by proteasome inhibitors. Autophagy machinery recruitment to the outer mitochondrial membrane protects cells from apoptosis by mediating the lysosomal degradation of dysfunctional mitochondria. The study highlights the major role of the autophagy machinery in counteracting abnormal noncanonical apoptosis and identifies autophagy receptors as key regulators of this process.
Article
Biochemistry & Molecular Biology
Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajaram
Summary: The present study investigates the effect and molecular mechanism of N-(2-hydroxyphenyl)-2-phenazinamine (NHP) from Nocardiopsis exhalans on human lung cancer cells. NHP exhibits excellent cytotoxic activity against A549 and H520 lung cancer cells at a concentration of 75 μg/mL, damaging the mitochondrial membrane and nucleus through oxidative stress. NHP causes nuclear condensation, induces apoptosis, down-regulates oncogenic genes, and upregulates apoptosis marker genes in lung cancer cells. NHP may have potential as an anticancer drug for lung cancer treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Juan M. Gonzalez-Morena, Sara Escudeiro-Lopes, Jessica Mariane Ferreira-Mendes, Pavel Jakoube, Valentina Cutano, Judith Vinaixa-Forner, Petra Kralova Viziova, Andrea Hartmanova, Radislav Sedlacek, Susana Machado, Beata Malcekova, Zuzana Keckesova
Summary: Our study provides a deeper understanding of the mechanism of LACTB-mediated cancer cell death and demonstrates the dynamics of cellular responses under different genetic backgrounds.
Article
Biochemistry & Molecular Biology
Xiaotong Zhao, Lijuan Jiao, Danting Liu, Tan Yang, Yanqing Zhang, Aimin Zhou, Zhiyou Wen, Kunsheng Zhang, Junbo Xie
Summary: In this study, phycoerythrin (PE) was extracted from Rhodomonas salina and characterized. The results showed that PE had an anticancer activity on human lung cancer A549 cells by inducing apoptosis via the activation of the ERK/Bak and JNK/caspase-3 signaling pathways. This suggests that PE may have potential for cancer prevention and as an immunostimulant in the pharmaceutical industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Ganyu Wang, Weiqiang Jing, Yuxuan Bi, Yue Li, Liang Ma, Hui Yang, Yuankai Zhang
Summary: The study identified neutrophil elastase (NE) as a significant factor in osteoarthritis (OA), inducing chondrocyte apoptosis and facilitating OA development via the caspase signaling pathway. Inhibition of NE showed potential as a therapy for OA by mitigating chondrocyte apoptosis and pathological processes in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gulcin Yavuz Turel, Nilufer Sahin Calapoglu, Dilek Bayram, Meltem Ozgocmen, Vehbi Atahan Togay, Eda Evgen Tuluceoglu
Summary: The study demonstrated that curcumin has inhibitory effects on cell proliferation and induces apoptosis in colon carcinoma cells. It suggests that curcumin could be a potential protective or treatment agent against colon cancer, but further research on curcumin-rich diets and bioavailability is needed.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Environmental Sciences
Haiying Wei, Wanjun Yuan, Huan Yu, Hong Geng
Summary: PM2.5 can induce apoptosis in alveolar macrophages, causing cytotoxic effects, increasing levels of reactive oxygen species and intracellular calcium ions, and leading to lung injury diseases through a mitochondrial-mediated pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Polymer Science
Balint Viktor Lovasz, Gergely Berta, Edina Lempel, Gyorgy Setalo, Monika Vecsernyes, Jozsef Szalma
Summary: The study suggests that relevant concentrations of TEGDMA monomers leached from resin-based composite materials (RBCs) induce apoptosis in pulp cells through both caspase-dependent and caspase-independent mechanisms, possibly involving endoplasmic reticulum stress and the activation of caspase-independent apoptotic pathways.
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Article
Biochemistry & Molecular Biology
Mi Jin Kim, Jinhong Park, Jinho Kim, Ji-Young Kim, Mi-Jin An, Geun-Seup Shin, Hyun-Min Lee, Chul-Hong Kim, Jung-Woong Kim
Summary: The study found that HgCl2 treatment inhibits cell growth by blocking the cell cycle at G(0)/G(1)- and S-phase, and induces apoptotic cell death through the caspase-3-independent pathway. Transcriptome analysis revealed that HgCl2 affects cellular nitrogen compound metabolism, cellular metabolism, and transcription-related gene sets, with notable alterations in mitochondrial ribosomal proteins with low-dose HgCl2 treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Li, Ting Chen, Xiaofen Wu, Xiao Jiang, Peng Luo, E. Zixuan, Chaoqun Hu, Chunhua Ren
Summary: Apoptosis is a critical biological process for embryonic development, tissue differentiation, and organism homeostasis. A novel apoptosis-inducing factor called AIF-2 has been identified in sea cucumbers, and it is involved in heavy metal-induced apoptosis, contributing to the understanding of the caspase-independent apoptotic pathway in ancient echinoderm species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zhou Fang, Haekyung Lee, Junying Liu, Karen A. Wong, Lewis M. Brown, Xiang Li, Alus M. Xiaoli, Fajun Yang, Ming Zhang
Summary: This study found that C3 can reduce myocardial apoptosis by interacting with the intrinsic apoptotic pathway in cardiomyocytes.
Review
Biotechnology & Applied Microbiology
Ouafae Akkouh, Tzi Bun Ng, Randy Chi Fai Cheung, Jack Ho Wong, Wenliang Pan, Charlene Cheuk Wing Ng, Ou Sha, Pang Chui Shaw, Wai Yee Chan
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2015)
Review
Biotechnology & Applied Microbiology
Randy Chi Fai Cheung, Jack Ho Wong, Wenliang Pan, Yau Sang Chan, Cuiming Yin, Xiuli Dan, Tzi Bun Ng
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Wen Liang Pan, Tzi Bun Ng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Review
Biochemistry & Molecular Biology
Ouafae Akkouh, Tzi Bun Ng, Senjam Sunil Singh, Cuiming Yin, Xiuli Dan, Yau Sang Chan, Wenliang Pan, Randy Chi Fai Cheung
Review
Biotechnology & Applied Microbiology
Tzi Bun Ng, Randy Chi Fai Cheung, Jack Ho Wong, Yau Sang Chan, Xiuli Dan, Wenliang Pan, Hexiang Wang, Suzhen Guan, Ki Chan, Xiuyun Ye, Fang Liu, Lixin Xia, Wai Yee Chan
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Senjam Sunil Singh, Hexiang Wang, Yau Sang Chan, Wenliang Pan, Xiuli Dan, Cui Ming Yin, Ouafae Akkouh, Tzi Bun Ng
Article
Plant Sciences
Yan Wang, Wei-Cheng Liang, Wen-Liang Pan, Wai-Kit Law, Jian-Shu Hu, Deriis Tsz-Ming Ip, Mary Miu-Yee Waye, Tzi-Bun Ng, David Chi-Cheong Wan
Article
Multidisciplinary Sciences
Michihito Kono, Nobuya Yoshida, Kayaho Maeda, Nicole E. Skinner, Wenliang Pan, Vasileios C. Kyttaris, Maria G. Tsokos, George C. Tsokos
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Medicine, Research & Experimental
Wenliang Pan, Amir Sharabi, Andrew Ferretti, Yinfeng Zhang, Catalina Burbano, Nobuya Yoshida, Maria G. Tsokos, George C. Tsokos
Article
Immunology
Wenliang Pan, Kamalpreet Nagpal, Abel Suarez-Fueyo, Andrew Ferretti, Nobuya Yoshida, Maria G. Tsokos, George C. Tsokos
Summary: The study reveals that an increase in the PP2A regulatory subunit PPP2R2A in T cells from patients with systemic lupus erythematosus enhances ROCK activity, leading to increased Th1 and Th17 cell differentiation, while deficiency of PPP2R2A reduces this differentiation and alleviates autoimmunity.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Marc Scherlinger, Wenliang Pan, Ryo Hisada, Afroditi Boulougoura, Nobuya Yoshida, Milena Vukelic, Masataka Umeda, Suzanne Krishfield, Maria G. Tsokos, George C. Tsokos
Summary: This study reveals the defective metabolism and function of Treg cells in systemic lupus erythematosus (SLE) and identifies CaMK4 and PFKP as key regulators. Targeting CaMK4 and PFKP holds promise for restoring Treg cell function and improving disease outcomes in SLE patients.
Article
Immunology
Wenliang Pan, Marc Scherlinger, Nobuya Yoshida, Maria G. Tsokos, George C. Tsokos
Summary: This study demonstrates that PPP2R2D, a regulatory subunit of protein phosphatase 2A, acts as a negative regulator of immune checkpoint receptors. Its absence exacerbates effector T cell exhaustion and promotes regulatory T cell expansion. The expression levels of PPP2R2D are positively correlated with the infiltration of immune cells in melanoma patients.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Esra Meidan, Hao Li, Wenliang Pan, Michihito Kono, Shuilian Yu, Vasileios C. Kyttaris, Christina Ioannidis, Noe Rodriguez Rodriguez, Jose C. Crispin, Sokratis A. Apostolidis, Pui Lee, John Manis, Amir Sharabi, Maria G. Tsokos, George C. Tsokos
Article
Medicine, Research & Experimental
Michihito Kono, Kayaho Maeda, Irina Stocton-Gavanescu, Wenliang Pan, Masataka Umeda, Eri Katsuyama, Catalina Burbano, Seo Yeon K. Orite, Milena Vukelic, Maria G. Tsokos, Nobuya Yoshida, George C. Tsokos
Article
Medicine, Research & Experimental
Amir Sharabi, Hao Li, Isaac R. Kasper, Wenliang Pan, Esra Meidan, Maria G. Tsokos, Vaishali R. Moulton, George C. Tsokos