Article
Multidisciplinary Sciences
Claire Fielding, Andres Garcia-Garcia, Claudia Korn, Stephen Gadomski, Zijian Fang, Juan L. Reguera, Jose A. Perez-Simon, Berthold Gottgens, Simon Mendez-Ferrer
Summary: Cholinergic signals in the bone marrow preserve haematopoietic stem cell quiescence and self-renewal under proliferative stress.
NATURE COMMUNICATIONS
(2022)
Review
Cell & Tissue Engineering
Xi-Min Hu, Zhi-Xin Li, Dan-Yi Zhang, Yi-Chao Yang, Shen-ao Fu, Zai-Qiu Zhang, Rong-Hua Yang, Kun Xiong
Summary: Hair follicle stem cells (HFSCs) are valuable resources for studying adult stem cells and hair loss therapy, with potential therapeutic targets for skin and hair disorders. Multiple signaling pathways are involved in regulating the fate of HFSCs, providing a better understanding of pathophysiological changes in the HFSC niche.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Xin Gao, Dachuan Zhang, Chunliang Xu, Huihui Li, Kathleen M. Caron, Paul S. Frenette
Summary: Nociceptive nerves play a role in enforcing HSC mobilization through CGRP secretion, collaborating with sympathetic nerves to maintain HSCs in the bone marrow. CGRP directly activates HSCs via the G alpha(s)/adenylyl cyclase/cAMP pathway, and consumption of capsaicin-containing food enhances HSC mobilization in mice.
Article
Biochemistry & Molecular Biology
Arnaldo Carreira-Rosario, Ryan A. York, Minseung Choi, Chris Q. Doe, Thomas R. Clandinin
Summary: Neural activity shapes circuit wiring in animals. Studies in Drosophila embryos show that neural activity precedes patterned spontaneous network activity (PaSNA), with highly consistent spatiotemporal properties, arguing for genetic programming. Inhibition of mechanosensory input and muscle contractions results in premature PaSNA, while transient mechanosensory inhibition during PaSNA affects larval foraging behavior. This work provides insight into how neural circuit formation is influenced by motor activity and highlights the importance of sensory feedback in shaping locomotor behaviors during development.
Review
Biochemistry & Molecular Biology
Peter Cuthbertson, Nicholas J. Geraghty, Sam R. Adhikary, Katrina M. Bird, Stephen J. Fuller, Debbie Watson, Ronald Sluyter
Summary: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective therapy for blood cancers and other haematological disorders, but may lead to graft-versus-host disease (GVHD). Current treatments for GVHD are limited, highlighting the need for exploring inflammatory factors to identify new treatment targets. Purinergic signalling, including purinergic receptors and ectoenzymes, has been implicated in influencing GVHD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jun Shen, Yaoyao Zhu, Shuo Zhang, Shuzhen Lyu, Cuicui Lyu, Zicen Feng, Dixie L. Hoyle, Zack Z. Wang, Tao Cheng
Summary: Objectives Vitronectin (VTN) has been shown to promote efficient haematopoietic differentiation of human pluripotent stem cells (hPSCs) by promoting the fate determination of endothelial-haematopoietic lineage during mesoderm development. Signals through alpha v beta 3 and alpha v beta 5 integrins are required for VTN-promoted haematopoietic differentiation. Knockdown experiments confirmed that alpha v beta 3 and alpha v beta 5 act synergistically for early haematopoietic differentiation.
CELL PROLIFERATION
(2021)
Article
Pharmacology & Pharmacy
Wenwen Xue, Wuhao Li, Ying Yu, Bo Zhang, Yixue Wang, Lin Zhou, Zhixiu Chen, Liwei Wang, Huiming Ge, Qiang Xu, Yan Shen
Summary: This study aimed to investigate the mode of action of indolocarbazole alkaloid loonamycin A against triple-negative breast cancer. Results showed that loonamycin A exhibited stronger cytotoxicity compared to its analog rebeccamycin, inhibiting cell proliferation, migration, and reducing the expression of stemness-associated genes. Additionally, loonamycin A enhanced the antitumour effects of paclitaxel by inhibiting Notch signalling.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Oncology
Nathalie Sphyris, Michael C. Hodder, Owen J. Sansom
Summary: The intestinal epithelium performs diverse functions, constantly renewing cells to maintain its barrier against toxins. Stem cells play a crucial role in this process under the guidance of the niche signals. Dysfunction of intestinal stem cells may contribute to the development of colorectal cancer.
Article
Developmental Biology
Clara Munger, Timo N. Kohler, Erin Slatery, Anna L. Ellermann, Sophie Bergmann, Christopher A. Penfold, Ioakeim Ampartzidis, Yutong Chen, Florian Hollfelder, Thorsten E. Boroviak
Summary: The early specification and rapid growth of extraembryonic membranes are distinctive characteristics of primate embryogenesis. This study investigates the signals involved in the formation of embryonic and extraembryonic lineages in primates by using microgel culture, single-cell profiling and spatial identity mapping. The findings reveal the crucial roles of activin/nodal signaling in embryonic lineage identity and BMP4 in amnion formation and maturation, counteracted by FGF signaling.
Review
Developmental Biology
Laurent Yvernogeau, Giovanna Dainese, Thierry Jaffredo
Summary: Recent studies have shown that the aorta microenvironment plays a crucial role in the generation of the first haematopoietic stem cells (HSCs) from specialized haemogenic endothelial cells (HECs). However, there is still a need for a deeper understanding of the cellular and molecular events involved in aorta formation and polarization, which are essential for HEC specification and HSC competency. This review compares the early mechanisms of aorta formation in different vertebrate species and discusses how the molecular signals from the aorta environment result in its polarization, creating a unique entity for HSC generation.
Article
Developmental Biology
Joana Esteves de Lima, Cedrine Blavet, Marie-Ange Bonnin, Estelle Hirsinger, Emmanuelle Havis, Frederic Relaix, Delphine Duprez
Summary: This study reveals the location and regulation of fusion events during skeletal muscle development. The researchers found that TMEM8C-positive cells and MYOG-positive cells in chicken embryos were co-localized in the limbs. These fusion-competent cells were preferentially located in the central regions of fetal muscles. Additionally, the study identified a lack of NOTCH activity in TMEM8C fusion-competent cells and showed that inhibiting NOTCH increased myoblast fusion and TMEM8C expression.
Article
Cell Biology
Zhen Dong, Chunyi Li, Dawn Coates
Summary: The growing deer antler contains a stem cell niche that drives bone regeneration at a rapid rate. PTN is a highly expressed growth factor in the antler stem cell tissues, with potential interactions with receptors such as PTPRZ and ALK. In vitro studies show that PTN does not induce differentiation or proliferation in antler stem cells, but rather maintains their stem cell status.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Joanna Kalafut, Arkadiusz Czerwonka, Karolina Czapla, Alicja Przybyszewska-Podstawka, Justyna Magdalena Hermanowicz, Adolfo Rivero-Muller, Lidia Borkiewicz
Summary: Notch1 signaling plays a diverse role in tissue development and homeostasis. The relationship between NOTCH1 expression and the development of health disorders, especially cancers, is intensively studied. Control of Notch1 signaling involves not only transcriptional regulation but also various post-translational events, including ligand-dependent mechanical activation and interaction with other signaling molecules, such as long non-coding RNAs (lncRNAs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xi Xu, Wenwen Zhang, Li Xuan, Yanhui Yu, Wen Zheng, Fang Tao, Jacqelyn Nemechek, Chong He, Weiwei Ma, Xue Han, Siyu Xie, Minyi Zhao, Jian Wang, Yuhua Qu, Qifa Liu, John M. Perry, Linjia Jiang, Meng Zhao
Summary: “T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy. In this study, a rare inhibitory receptor called programmed cell death 1 (PD-1) was identified as a marker for leukemia stem cells (LSCs) in T-ALL. Blocking PD-1 significantly eradicated LSCs and suppressed disease progression, and combination therapy with PD-1 blockade and chemotherapy extended survival. Mechanistically, PD-1+ LSCs had high NOTCH1-MYC activity and were protected against apoptosis. These findings provide a therapeutic approach for eliminating LSCs in T-ALL.”
NATURE CELL BIOLOGY
(2023)
Article
Cell Biology
Carl A. Mitchell, Evgenia V. Verovskaya, Fernando J. Calero-Nieto, Oakley C. Olson, James W. Swann, Xiaonan Wang, Aurelie Herault, Paul V. Dellorusso, Si Yi Zhang, Arthur Flohr Svendsen, Eric M. Pietras, Sietske T. Bakker, Theodore T. Ho, Berthold Gottgens, Emmanuelle Passegue
Summary: Haematopoietic ageing is characterized by a loss of regenerative capacity and abnormal differentiation of haematopoietic stem cells (HSCs), resulting in impaired blood production. The study reveals an inflammatory environment in the old bone marrow niche, which contributes to niche deterioration, HSC dysfunction, and impaired haematopoietic regeneration. The production of interleukin-1 beta (IL-1 beta) by damaged endosteum drives the proinflammatory nature of the central marrow, causing damage to the old blood system. Blocking IL-1 signaling is a potential strategy to improve blood production during ageing.
NATURE CELL BIOLOGY
(2023)
Article
Cell Biology
Andrea Loreto, Michele Di Stefano, Martin Gering, Laura Conforti
Article
Developmental Biology
Roshana Thambyrajah, Deniz Ucanok, Maryam Jalali, Yasmin Hough, Robert Neil Wilkinson, Kathryn McMahon, Chris Moore, Martin Gering
DEVELOPMENTAL BIOLOGY
(2016)
Article
Hematology
Caroline Gray, David Bratt, Julie Lees, Marc daCosta, Karen Plant, Oliver J. Watson, Sara Solaymani-Kohal, Simon Tazzyman, Jovana Serbanovic-Canic, David C. Crossman, Bernard D. Keavney, Andrea Haase, Kathryn McMahon, Martin Gering, Henry Roehl, Paul C. Evans, Timothy J. A. Chico
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Hematology
Jonathan M. Rowlinson, Martin Gering
Article
Cardiac & Cardiovascular Systems
Oliver Watson, Peter Novodvorsky, Caroline Gray, Alexander M. K. Rothman, Allan Lawrie, David C. Crossman, Andrea Haase, Kathryn McMahon, Martin Gering, Fredericus J. M. Van Eeden, Timothy J. A. Chico
CARDIOVASCULAR RESEARCH
(2013)
Editorial Material
Cell & Tissue Engineering
Martin Gering, Roger Patient
Article
Cell Biology
Robert N. Wilkinson, Claire Pouget, Martin Gering, Angela J. Russell, Stephen G. Davies, David Kimelman, Roger Patient
DEVELOPMENTAL CELL
(2009)
Article
Biochemistry & Molecular Biology
Rimple D. Almeida, Matthew Loose, Virginie Sottile, Elena Matsa, Chris Denning, Lorraine Young, Andrew D. Johnson, Martin Gering, Alexey Ruzov
Article
Multidisciplinary Sciences
Ami Ketley, Anne Warren, Emily Holmes, Martin Gering, A. Aziz Aboobaker, J. David Brook
Review
Cell Biology
Peter Jessop, Alexey Ruzov, Martin Gering
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)
Article
Hematology
Chris Moore, Joanna L. Richens, Yasmin Hough, Deniz Ucanok, Sunir Malla, Fei Sang, Yan Chen, Stone Elworthy, Robert N. Wilkinson, Martin Gering
Article
Biochemistry & Molecular Biology
Michele Di Stefano, Andrea Loreto, Giuseppe Orsomando, Valerio Mori, Federica Zamporlini, Richard P. Hulse, Jamie Webster, Lucy F. Donaldson, Martin Gering, Nadia Raffaelli, Michael P. Coleman, Jonathan Gilley, Laura Conforti
Article
Hematology
Lucy J. Patterson, Martin Gering, Craig E. Eckfeldt, Anthony R. Green, Catherine M. Verfaillie, Stephen C. Ekker, Roger Patient
Article
Developmental Biology
Natalia Meier, Sanja Krpic, Patrick Rodriguez, John Strouboulis, Maria Monti, Jeroen Krijgsveld, Martin Gering, Roger Patient, Arnd Hostert, Frank Grosveld
