Article
Chemistry, Analytical
Xinyue Zhao, Lulu Ning, Xiaoman Zhou, Zhihui Song, Jianjian Zhang, Feng Guan, Xiao-Feng Yang
Summary: Hydrogen sulfide (H2S) is a vital endogenous signal molecule with critical physiological functions, but its site-specific delivery and release in biological systems remains a challenge. The newly developed Pro-S donor shows excellent release efficiency and live-cell compatibility, allowing real-time capturing of H2S and demonstrating anti-inflammatory effects in cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Natalya Dorofeyeva, Konstantin Drachuk, Rajasekaran Rajkumar, Omkar Sabnis, Vadim Sagach
Summary: The study demonstrates that exogenous hydrogen sulfide can improve heart function and endothelium-dependent relaxation in diabetic rats. Pretreatment with NaHS can prevent endothelial dysfunction in diabetes through a NOS-dependent mechanism.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Kumru Turhan, Elif Alan, Gunay Yetik-Anacak, Gulnur Sevin
Summary: Pulmonary arterial hypertension is caused by complex changes in the endothelial and smooth muscle cells of pulmonary arteries. Hydrogen sulfide (H2S) has potential to treat this condition by relaxing the arteries and reducing pressure. This study found that H2S levels were decreased and endothelium-dependent vasorelaxation was impaired in monocrotaline-induced pulmonary arterial hypertension. However, treatment with the H2S donor, Na2S, prevented endothelial dysfunction, increased artery pressure, and restored H2S levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Valerio Ciccone, Eugenia Piragine, Era Gorica, Valentina Citi, Lara Testai, Eleonora Pagnotta, Roberto Matteo, Nicola Pecchioni, Rosangela Montanaro, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Vincenzo Brancaleone, Lucia Morbidelli, Vincenzo Calderone, Alma Martelli
Summary: This study found that erucin has anti-inflammatory effects, reducing the emigration of neutrophils, protecting endothelial cells from oxidative damage and tumor necrosis factor α-mediated injury, decreasing endothelial hyperpermeability, and reducing the expression of inflammatory proteins. Additionally, erucin regulates endothelial function through inducing eNOS phosphorylation and inhibiting NF-kappa B nuclear translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lyudmila V. Nedosugova, Yuliya V. Markina, Leyla A. Bochkareva, Irina A. Kuzina, Nina A. Petunina, Irina Y. Yudina, Tatiana V. Kirichenko
Summary: The association between type 2 diabetes and cardiovascular complications is complex, primarily due to the oxidative stress and inflammation caused by hyperglycemia. Understanding the pathogenesis of type 2 diabetes and associated cardiovascular diseases can aid in the development of new diagnostic and therapeutic approaches.
Article
Engineering, Biomedical
Bingyang Lu, Xiao Han, Ansha Zhao, Dan Luo, Manfred F. Maitz, Haohao Wang, Ping Yang, Nan Huang
Summary: Coronary atherosclerosis lesions exhibit a low-pH chronic inflammatory response. A novel method using pH-responsive self-assembling films with hydrogen sulfide (H2S) releasing aspirin derivative ACS14 as drug has been developed to regulate drug release adjusted to the lesion's microenvironment, promoting self-healing capacity of blood vessels. Experimentation showed promising results for treating cardiovascular diseases.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Maria A. Munoz-Vargas, Javier Lopez-Jaramillo, Salvador Gonzalez-Gordo, Alberto Paradela, Jose M. Palma, Francisco J. Corpas
Summary: This study aims to analyze the interrelationship between nitric oxide (NO) and hydrogen sulfide (H2S) during pepper fruit ripening. The results show that the activity of H2S-generating enzymes LCD and DCD is downregulated during ripening, but it can be reversed by NO treatment. These findings enhance our understanding of the relationship between NO and H2S during pepper fruit ripening.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Agriculture, Multidisciplinary
Wenwen Jiang, Dan Zhu, Longgang Zhao, Yu Liu, Chaoping Wang, Muhammad Salman Farid, Yuyi Gu, Jing Li, Tianhao Li, Yanan Sun, Wenxiang Li, Fansheng Cheng
Summary: Treatment with L-Cys can delay the aging process, reduce browning and weight loss, improve soluble protein and total phenolic content, and enhance antioxidant enzyme activity in fresh-cut button mushrooms.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Soumya Mukherjee, Satish C. Bhatla
Summary: This study provides evidence on the role of melatonin in modulating H2S homeostasis during NaCl stress in dark-grown tomato seedlings. Exogenous melatonin and H2S together have an additive effect in ameliorating NaCl stress-induced growth changes in tomato seedlings, indicating their potential as stress regulators in plants.
JOURNAL OF PLANT GROWTH REGULATION
(2021)
Article
Biochemistry & Molecular Biology
Alma Martelli, Eugenia Piragine, Era Gorica, Valentina Citi, Lara Testai, Eleonora Pagnotta, Luca Lazzeri, Nicola Pecchioni, Valerio Ciccone, Rosangela Montanaro, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Vincenzo Brancaleone, Lucia Morbidelli, Vincenzo Calderone
Summary: The study demonstrates that erucin can effectively prevent high glucose-induced endothelial dysfunction and inflammation by inhibiting ROS and inflammatory markers levels, protecting vascular cell integrity, and also has a certain inhibitory effect on the increase in vascular permeability.
Review
Food Science & Technology
Yayi Jiang, Rensong Yue, Guojie Liu, Jun Liu, Bo Peng, Maoyi Yang, Lianxue Zhao, Zihan Li
Summary: Garlic, a medicinal plant and functional food, has shown positive effects in the treatment of diabetes and its complications. This article provides a clear and comprehensive summary of the research from the past ten years, focusing on the mechanisms and development processes of garlic in the treatment of diabetes, aiming to provide a new perspective for the treatment of diabetes and promote the efficient development of this field.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Analytical
Chen Xu, Yukun Zhang, Hui Sun, Jindong Ai, Mingguang Ren
Summary: We have developed a new two-photon fluorescent probe (T-HS) for the detection of H2S. The probe exhibits regular changes in absorption and fluorescence spectra upon addition of hydrogen sulfide. It demonstrates advantageous properties such as a large turn-on fluorescence signal, good selectivity, and low cytotoxicity. Furthermore, the probe T-HS has been successfully utilized for fluorescence imaging of H2S in live cells and zebrafish.
ANALYTICAL METHODS
(2023)
Article
Plant Sciences
Huihui Fang, Zhenyuan Yu, Kehong Xing, Lingyi Zhou, Yuke Shao, Xiaofang Zhang, Yanxi Pei, Lu Zhang
Summary: Numerous studies have shown that hydrogen sulfide (H2S) functions as a gasotransmitter in various biological processes. However, its involvement in sulfur metabolism and/or Cys synthesis makes its role as a signaling molecule unclear. In this study, we found that exogenous H2S fumigation and Cys treatment affected the production rate and content of endogenous H2S and Cys. Transcriptomic analysis revealed that H2S regulates gene expression independently of Cys, mainly involved in plant hormone signal transduction and plant-pathogen interaction.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maria A. Munoz-Vargas, Salvador Gonzalez-Gordo, Jose M. Palma, Francisco J. Corpas
Summary: The study revealed variations in endogenous hydrogen sulfide (H2S) content and emission among different plants, with the highest levels found in Allium species. The activity of L-cysteine desulfhydrase (LCD) correlated positively with H2S content in plants, particularly in Allium species, suggesting potential health benefits associated with consuming these plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wenqiang Chang, Ming Zhang, Xueyang Jin, Haijuan Zhang, Hongbo Zheng, Sha Zheng, Yanan Qiao, Haina Yu, Bin Sun, Xuben Hou, Hongxiang Lou
Summary: The emergence of antifungal resistance necessitates the search for alternative antifungal agents. This study identified cystathionine beta-synthase (CBS) as a major enzyme involved in hydrogen sulfide synthesis in the pathogenic fungus Candida albicans. The inhibitor of CBS, protolichesterinic acid, neutralized the virulence of C. albicans and showed therapeutic efficacy in a mouse candidiasis model.
Review
Food Science & Technology
Dibyendu Das, Sanjib Sarkar, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Summary: Fermented soy foods have gained attention for their promising health benefits, particularly for their potential therapeutic effects against inflammation and related complications. Studies suggest that extracts from fermented soy foods possess anti-inflammatory properties by regulating the expression and activity of various inflammatory factors. These findings suggest that fermented soy foods have the potential to be used as anti-inflammatory agents in the future.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Dibyendu Das, Mir Ekbal Kabir, Sanjib Sarkar, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Summary: Soy protein has anti-diabetic properties and can prevent and control abnormalities related to diabetes, with a significant correlation between soy protein intake and lower prevalence of diabetes. Soy-derived peptides can also trigger anti-diabetic responses by modulating cell signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Sagar Barge, Dhananjay Jade, Selvaraj Ayyamperumal, Prasenjit Manna, Jagat Borah, Chandrasekar Moola Joghee Nanjan, Moola Joghee Nanjan, Narayan Chandra Talukdar
Summary: The study utilized in silico strategy to screen potential inhibitors for FKBP51, identifying compounds with good affinity and stability towards the protein. The selected compounds have the potential to be developed into therapeutic agents for stress and metabolic-related disorders.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Environmental Sciences
Rubi Barman, Jadumoni Saikia, Firdaus Rahaman Gayen, Biswajit Saha, Prasenjit Manna, Saikat Haldar, Pallab Pahari, Siddhartha Proteem Saikia, Dipanwita Banik
Summary: This study characterized the physicochemical properties of crude seed kernel wax of Endocomia macrocoma subsp. prainii (EW) and compared it with bee wax (BW). The results showed that EW is a novel natural wax with industrial potential, similar to BW.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Biology
Prateek Singh, Rajat Ujjainiya, Satyartha Prakash, Salwa Naushin, Viren Sardana, Nitin Bhatheja, Ajay Pratap Singh, Joydeb Barman, Kartik Kumar, Saurabh Gayali, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Amit Lahiri, Susanta Kar, Vivek Bhosale, Mrigank Srivastava, Madhav Nilakanth Mugale, C. P. Pandey, Shaziya Khan, Shivani Katiyar, Desh Raj, Sharmeen Ishteyaque, Sonu Khanka, Ankita Rani, Promila, Jyotsna Sharma, Anuradha Seth, Mukul Dutta, Nishant Saurabh, Murugan Veerapandian, Ganesh Venkatachalam, Deepak Bansal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Ravindra P. Veeranna, Anirban Pal, Ranvijay Kumar Singh, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Syed Nasar Rahman, Gopika Selvakumar, Subramanian Venkatesan, Malay Kumar Karmakar, Harish Kumar Sardana, Anamika Kothari, Devendra Singh Parihar, Anupma Thakur, Anas Saifi, Naman Gupta, Yogita Singh, Ritu Reddu, Rizul Gautam, Anuj Mishra, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Yogendra Padwad, Vikram Patial, Vipin Hallan, Damanpreet Singh, Narendra Tirpude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Ramakrishna Sistla, Narender Kumar Balthu, Kiran A. Kumar, Siva Ranjith, B. Vijay Kumar, Piyush Singh Jamwal, Anshu Wali, Sajad Ahmed, Rekha Chouhan, Sumit G. Gandhi, Nancy Sharma, Garima Rai, Faisal Irshad, Vijay Lakshmi Jamwal, Masroor Ahmad Paddar, Sameer Ullah Khan, Fayaz Malik, Debashish Ghosh, Ghanshyam Thakkar, S. K. Barik, Prabhanshu Tripathi, Yatendra Kumar Satija, Sneha Mohanty, Md Tauseef Khan, Umakanta Subudhi, Pradip Sen, Rashmi Kumar, Anshu Bhardwaj, Pawan Gupta, Deepak Sharma, Amit Tuli, Saumya Ray Chaudhuri, Srinivasan Krishnamurthi, L. Prakash, Ch Rao, B. N. Singh, Arvindkumar Chaurasiya, Meera Chaurasiya, Mayuri Bhadange, Bhagyashree Likhitkar, Sharada Mohite, Yogita Patil, Mahesh Kulkarni, Rakesh Joshi, Vaibhav Pandya, Sachin Mahajan, Amita Patil, Rachel Samson, Tejas Vare, Mahesh Dharne, Ashok Giri, Sachin Mahajan, Shilpa Paranjape, G. Narahari Sastry, Jatin Kalita, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, RaviKumar Sahu, Prachurjya Dutta, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Elapavalooru V. S. S. K. Babu, Rajeev K. Sukumaran, Aishwarya R. Nair, Anoop Puthiyamadam, Prajeesh Kooloth Valappil, Adrash Velayudhan Pillai Prasannakumari, Kalpana Chodankar, Samir Damare, Ved Varun Agrawal, Kumardeep Chaudhary, Anurag Agrawal, Shantanu Sengupta, Debasis Dash
Summary: Data science has played a crucial role in the COVID-19 pandemic response, and this study demonstrates how a statistical and machine learning approach can be used to discriminate between SARS-CoV-2 infection and immune response to a whole virion vaccine. By analyzing serial antibody data and incorporating an ensemble ML model, the researchers were able to accurately classify potential infections and validate their findings through neutralization assays. This study highlights the importance of real-world vaccine effectiveness assessments for whole virion vaccines.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Food Science & Technology
Prasenjit Manna, Saikat Dewanjee, Swarnalata Joardar, Pratik Chakraborty, Hiranmoy Bhattacharya, Shrestha Bhanja, Chiranjib Bhattacharyya, Manas Bhowmik, Shovonlal Bhowmick, Achintya Saha, Joydeep Das, Parames C. Sil
Summary: This study revealed that CA has a protective effect against Dox-induced cardiotoxicity by suppressing oxidative stress and interfering with pathological signaling events. CA can potentially be used as an effective agent to alleviate Dox-induced cardiotoxicity in the future.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Simanta Bharadwaj, Shalini Gurumayum Devi, Pranamika Sarma, Barsha Deka, Sagar Ramrao Barge, Bhaswati Kashyap, Yunus Sheikh, Prasenjit Manna, Jagat C. Borah, Narayan Chandra Talukdar
Summary: This study showed that Premna herbacea and its active constituent, Verbascoside, have a beneficial effect on hepatic steatosis caused by a high fat diet. By regulating the AMPK/SREBP/ACC/HMGCR signaling pathways, Premna herbacea and Verbascoside can prevent and improve hepatic steatosis. This suggests that Premna herbacea may be a potential functional food for managing hepatic steatosis.
Article
Biochemistry & Molecular Biology
Rajesh Parsanathan, Sushil K. Jain
Summary: Irisin, a novel myokine, is involved in glucose homeostasis through the activation of PGC-1 alpha/FNDC5/Irisin signaling pathway. This study found that deficiency of hydrogen sulfide (H2S) leads to decreased secretion of FNDC5 and Irisin and alters glucose metabolism, while upregulation of H2S levels has beneficial effects on glucose homeostasis.
Article
Biochemistry & Molecular Biology
Dibyendu Das, Sanjib Sarkar, Anjum Dihingia, Nazim Uddin Afzal, Sawlang Borsingh Wann, Jatin Kalita, Saikat Dewanjee, Prasenjit Manna
Summary: This study examined the antidiabetic efficacy of popular fermented soybean foods from Northeast India. Results showed that aqueous extract of Hawaijar significantly augmented glucose utilization and improved glucose metabolism in cultured myotubes and diabetic rats. Chemical profiling suggests the possible role of bioactive proteins/peptides and isoflavones underlying the antihyperglycemic potential of Hawaijar. These findings may contribute to the development of food-based prophylactics/therapeutics for managing hyperglycemia.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Sushil K. Jain, William E. McLean, Christopher M. Stevens, Richa Dhawan
Summary: This study found a significant positive association between circulating vitamin C levels and bone mineral density (BMD), and a significant negative association between total adiponectin and VCAM-1 levels with vitamin C and BMD. The study suggests that dietary vitamin C consumption may lower inflammation and reduce the risk of osteoporosis in patients with diabetes.
Review
Biochemistry & Molecular Biology
Sanjib Sarkar, Mir Ekbal Kabir, Jatin Kalita, Prasenjit Manna
Summary: Mesoporous silica nanoparticles (MSNs) are extensively used in biomedical applications such as drug delivery, diagnosis, bio-sensing, and cell tracking due to their unique properties. MSNs have been extensively studied in drug delivery field due to their highly ordered mesopores, high surface area, stability, and biocompatibility. MSN-based nanocomposites have been utilized for delivering therapeutic molecules for diabetes management. This review focuses on the delivery of antidiabetic therapeutics with emphasis on the functionalization of MSNs and stimuli-responsive delivery.
Review
Medicine, General & Internal
Jeffrey Justin Margret, Sushil K. Jain
Summary: Gene optimizations are crucial for maintaining biological functions, and gene dysregulation can lead to disease progression. Advanced analytical techniques help establish connections between impaired genes and disease conditions. This knowledge can be used to design clinical trials for novel therapeutic interventions and disease prevention.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Nanoscience & Nanotechnology
Purna K. Boruah, Priyakshree Borthakur, Gayatri Neog, Benjamin Le Ouay, Nazim Uddin Afzal, Prasenjit Manna, Manash R. Das
Summary: This article describes the synthesis of porous 3D nitrogen-doped crumpled graphene nanoparticles (CGNPs) and their use as a platform for the sensitive detection of dopamine (DA) in complex biological media such as blood serum. The CGNPs were prepared by doping graphene oxide (GO) using ammonium hydroxide in a hydrothermal treatment. The system selectively detected DA with a limit of detection of 1.15 μM and a linearity range of 1 to 20 μM, and it showed good selectivity in the presence of various interfering species and in human blood serum.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Sushil K. Jain, Jeffrey Justin Margret, Marissa Lally
Summary: The incidence of Alzheimer's disease is higher in people over the age of 65 and in African Americans. This study discovered a negative association between plasma AChE levels and H2S levels, and a positive association between AChE levels and age, NLR, ROS, and HbA1c levels in African Americans. The study also suggests that hyperglycemia and lower H2S levels may contribute to an increase in AChE activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Pranamika Sarma, Simanta Bharadwaj, Deepsikha Swargiary, Semim Akhtar Ahmed, Yunus Sheikh, Sagar Ramrao Barge, Prasenjit Manna, Narayan Chandra Talukdar, Jayanta Bora, Jagat Chandra Borah
Summary: This study conducted phytochemical investigation on traditional herb Wendlandia glabrata to explore its antihyperglycemic effect. The results showed that the enriched fraction of W. glabrata had significant blood glucose lowering potential and improved hepatic insulin resistance through regulating the AMPK/PEPCK/G6Pase signaling pathway.
NEW JOURNAL OF CHEMISTRY
(2022)