Review
Pharmacology & Pharmacy
Bahareh Zarin, Azadeh Eshraghi, Farzaneh Zarifi, Shaghayegh Haghjooy Javanmard, Ismail Laher, Bahareh Amin, Golnaz Vaseghi
Summary: Gastric cancer shows resistance to chemotherapy, with tau protein and stathmin being overexpressed in the cancer cells, contributing to disease progression. They could serve as significant molecular biomarkers for prognosis in gastric cancer, and potential candidates for targeted therapy, particularly in cases resistant to taxanes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ruiyan Cen, Liqun Wang, Yongqing He, Chenda Yue, Yang Tan, Lingfei Li, Xia Lei
Summary: This study reveals an important role of stathmin in the migration and proliferation of dermal fibroblasts. Stathmin is shown to increase with p38/MAPK pathway activation in response to lipopolysaccharide stimulation, resulting in microtubule depolymerization and increased migration and proliferation of dermal fibroblasts. Targeting stathmin or the p38/MAPK pathway could be a potential strategy for clinical interventions in wound healing.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Zhongcheng Zhu, Yuan Zhou, Yongheng Chen, Zhongyi Zhou, Wenxue Liu, Linyi Zheng, Qian Pei, Fengbo Tan, Haiping Pei, Yuqiang Li
Summary: KIAA1429, a component of the m(6)A methyltransferase complex, is found to be involved in cisplatin resistance in gastric cancer cells by stabilizing FOXM1 mRNA via YTHDF1. This study suggests that KIAA1429 could be a potential therapeutic target for overcoming cisplatin resistance in gastric cancer.
Article
Pharmacology & Pharmacy
Mikihiro Yoshie, Akari Ishida, Haruka Ohashi, Nami Nakachi, Mana Azumi, Kazuhiro Tamura
Summary: The study investigated the role of stathmin in the antiproliferative activity of eribulin in breast cancer cells. The results suggest that stathmin dynamics are closely associated with the antiproliferative effects of eribulin and stathmin is a possible biomarker for predicting the therapeutic effects of eribulin in breast cancer patients.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Cell Biology
Danilo Lopes, Alexandre L. Seabra, Bernardo Orr, Helder Maiato
Summary: This study identifies high alpha-tubulin acetylation as a potential biomarker for cancer cell response to taxol and uncovers a mechanistic link between alpha-tubulin detyrosination and the suppression of MCAK activity in taxol-induced cytotoxicity.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Shengwei Zhang, Jing Wang, Weichao Hu, Lijiao He, Qingyun Tang, Jie Li, Mengmeng Jie, Xinzhe Li, Cheng Liu, Ouyang Qin, Shiming Yang, Changjiang Hu
Summary: This study demonstrates that RNF112 suppresses the progression of gastric cancer by ubiquitinating FOXM1, and highlights the RNF112/FOXM1 axis as both a prognostic biomarker and a therapeutic target in gastric cancer. Furthermore, the small-molecule compound RCM-1 enhances the interaction between RNF112 and FOXM1, promoting FOXM1 ubiquitination and exerting promising anticancer effects in vitro and in vivo.
Article
Biotechnology & Applied Microbiology
Mingrui Shao, Li Wang, Qi Zhang, Tianlong Wang, Shiyang Wang
Summary: STMN2 is overexpressed in pancreatic ductal adenocarcinoma (PC) and is associated with tumor aggressiveness and poor prognosis. STMN2 overexpression promotes EMT-like cellular transformation and cell proliferation in PC.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hannah R. R. Belsham, Hanan M. M. Alghamdi, Nikita Dave, Alexandra J. J. Rathbone, Bill Wickstead, Claire T. T. Friel
Summary: The kinesin-13 family consists of microtubule depolymerizing kinesins that play crucial roles in regulating microtubule length. A synthetic ancestral kinesin-13 motor domain was created to better understand the evolution of microtubule depolymerization activity. This study found that the ancestral kinesin-13 motor depolymerizes stabilized microtubules faster than any previously tested depolymerase, suggesting that kinesin-13 family members have evolved to provide more controlled microtubule depolymerization activity.
Article
Cell Biology
Mikhail S. Chesnokov, Marianna Halasi, Soheila Borhani, Zarema Arbieva, Binal N. Shah, Rick Oerlemans, Irum Khan, Carlos J. Camacho, Andrei L. Gartel
Summary: STL427944 selectively suppresses FOXM1 by inducing its relocalization and subsequent degradation, leading to increased sensitivity of cancer cells to conventional chemotherapeutic treatments.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Yongming Jiang, Hui Zhao, Yuxiao Chen, Kangjian Li, Tianjie Li, Jianheng Chen, Baiyu Zhang, Caifen Guo, Liangliang Qing, Jihong Shen, Xiaodong Liu, Peng Gu
Summary: Exosomal lncRNA HOXD-AS1 is upregulated in CRPC and metastatic PCa, promoting cancer cell metastasis by modulating the miR-361-5p/FOXM1 axis. Serum exosomal HOXD-AS1 is correlated with disease characteristics and survival outcomes, serving as a potential liquid biopsy biomarker for metastatic PCa detection and treatment guidance.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Ha Hyung Moon, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Dorothea Schulte, Christine Solbach, Frank Louwen, Juping Yuan, Andreas Ritter
Summary: The microtubule cytoskeleton regulator MCAK plays a critical role in cell motility and migration by affecting the dynamics of actin-MT cytoskeleton and FA turnover, potentially promoting malignant progression and metastasis of tumor cells.
Article
Pharmacology & Pharmacy
Mana Azumi, Mikihiro Yoshie, Nami Nakachi, Atsuya Tsuru, Kazuya Kusama, Kazuhiro Tamura
Summary: Eribulin plays a significant role in modulating stathmin expression in uterine leiomyosarcoma cells, inducing stathmin phosphorylation and reducing its protein levels. Stathmin expression levels can impact the effects of eribulin on cell viability and anti-proliferation efficacy.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Hanzhao Yang
Summary: Breast cancer is a common malignant tumor in women, and chemotherapy may lead to multidrug resistance. Recent studies have shown that the upregulation of stathmin and tau expression in various malignant tumors may promote the occurrence and progression of cancer. This literature review summarizes the expression of these two proteins in breast cancer and their involvement in treatment methods.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yan Zhang, Lin Chen, Xuanting Ye, Zhixiong Wu, Zeyu Zhang, Biaofeng Sun, Hong Fu, Chuangang Fu, Xiaofei Liang, Hong Jiang
Summary: The study revealed that FRLnc1 in exosomes plays a role in promoting the growth and metastasis of gastric cancer by enhancing cell proliferation and migration. This suggests that FRLnc1 may serve as a potential biomarker for the diagnosis and treatment of gastric cancer, providing a new avenue for therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shufeng Bu, Wei Lin Yong, Bryan Jian Wei Lim, Shu Kondo, Fengwei Yu
Summary: This research systematically investigated microtubule-destabilizing factors and identified Efa6 and Stai as new regulators of dendrite pruning in ddaC sensory neurons during Drosophila metamorphosis. They facilitate microtubule turnover and disassembly prior to dendrite pruning without affecting microtubule orientation, highlighting the importance of microtubule disassembly in promoting dendrite pruning and establishing a causal link between the two processes.