Review
Endocrinology & Metabolism
Yue Wu, Yunjiao Yang, Lan Wang, Yiding Chen, Xuke Han, Lisha Sun, Huizhen Chen, Qiu Chen
Summary: Osteoporosis is a bone disease characterized by low bone quality and density, causing bone fragility and vulnerability to fractures. Increased osteoclast differentiation and activity contribute to bone loss, a common manifestation of osteoporosis. The TNF-a/NF-κB inflammatory pathway plays a key role in regulating osteoclast formation, along with the classical RANKL/RANK/OPG pathway. Probiotics, particularly Bifidobacterium, have shown potential beneficial effects on bone health by modulating this pathway. This review discusses the molecular mechanisms of the TNF-a/NF-κB pathway in osteoclast formation and explores the secretions produced by Bifidobacterium, providing new directions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Qin Qin, Kai Hu, Zifang He, Feifei Chen, Wenwen Zhang, Yajun Liu, Zhenggao Xie
Summary: Fungal keratitis is a common cause of blindness in China, especially in individuals with diabetes. This study investigated the role and mechanism of Resolvins D1 (RvD1) in diabetic Aspergillus fumigatus keratitis. The results showed that RvD1 reduced oxidative stress, inflammation, fungal growth, and immunoreaction in corneal cells infected with A. fumigatus. RvD1 also inhibited lymphangiogenesis and angiogenesis, potentially providing a therapeutic target for fungal keratitis in diabetes.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, the post-translational modification of Tollip by ubiquitination was identified. Tollip interacts with RNF167 and RNF167 functions as the E3 ligase to attach poly-ubiquitin chains to Tollip. The ubiquitination of Tollip plays a crucial role in TNF-alpha signaling.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Pharmacology & Pharmacy
Weiwei Yuan, Jinxi Huang, Shanshan Hou, Huahua Li, Liangyu Bie, Beibei Chen, Gaofeng Li, Yang Zhou, Xiaobing Chen
Summary: The study found that pretreatment of gastric cancer cells with triptolide can enhance its anti-tumor effect. This effect is dependent on the disruption of the H19/miR-204-5p/NF-kappa B/FLIP axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida
Summary: This study found that Medermycin (MED) can reduce inflammatory reactions in synovial cells and inhibit the expression of proinflammatory cytokines. Further experiments demonstrated that MED can also inhibit the activation of NF?B and Akt, thereby modulating the inflammatory response. These results highlight the potential therapeutic value of MED in managing inflammatory conditions in osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
James M. Murphy, Kyuho Jeong, Donna L. Cioffi, Pamela Moore Campbell, Hanjoong Jo, Eun-Young Erin Ahn, Ssang-Taek Steve Lim
Summary: The study reveals that focal adhesion kinase (FAK) plays a crucial role in regulating sustained NF-kappa B activation in endothelial cells (ECs) stimulated by tumor necrosis factor-alpha (TNF-alpha). Inhibition of FAK disrupts the formation of TNF-alpha receptor complex-I (TNFRC-I) and diminishes recruitment of downstream proteins, leading to reduced NF-kappa B activity. Targeting FAK may hold promise for treating chronic inflammatory diseases.
Article
Pharmacology & Pharmacy
Nghia Trong Vo, Saki Sasaki, Yasunobu Miyake, Nhan Trung Nguyen, Phu Hoang Dang, Mai Thanh Thi Nguyen, Takao Kataoka
Summary: Alpha-conidendrin inhibits the expression of ICAM-1 in lung adenocarcinoma cells and interferes with the NF-κB signaling pathway induced by TNF-α.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Milton Roy, Rajesh Singh
Summary: TRIMs, as RING domain-containing E3 ligases, are involved in regulating the NF-kappa B pathway and may lead to unique outcomes in different pathophysiological conditions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiuying Zhang, Qilei Chen, Jia Zhao, Wei Zhao, Ni Fan, Yu Wang, Hubiao Chen, Jianhui Rong
Summary: This study aimed to investigate the cardioprotective activity of the herbal medicine formula Baoyuan Decoction (BYD), identify the active compounds and molecular targets. The results showed that BYD effectively reduced infarct size and preserved cardiac functions. Network pharmacology analysis revealed that BYD might control cardiac inflammation through targeting the TNF-alpha/NF-kappa B pathway and other related pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Silvia Marino, Nicole Hannemann, Ryan T. Bishop, Feier Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Baeuerle, Slobodan Vukicevic, Marielle Auberval, Patrick Mollat, Aline Bozec, Aymen I. Idris
Summary: TRAF6 inhibitors may be beneficial in managing the inflammatory component of bone disorders, but they may not provide protection against local or systemic bone loss unless combined with anti-resorptive therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Hang Liu, Xueyan Dai, Shiwen Xu, Huiling Guo, Jiamei Zhu, Sunan Wang, Yuning Wu, Caiying Zhang
Summary: This study investigated the effects of molybdenum (Mo) and cadmium (Cd) on myocardium injury in ducks and the function of NF-κB/TNF-α axis. The findings showed that the accumulation of Mo and/or Cd caused elements imbalance and necroptosis in myocardial tissue. Mo and/or Cd induced necroptosis via the NF-κB/TNF-α axis and decreased death receptor-mediated apoptosis in duck myocardium, with different effects on mitochondrial-mediated apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)