Article
Chemistry, Multidisciplinary
Peixin Guan, Zhanchen Guo, Shuxin Xu, Haifeng Lu, Lisheng Wang, Zikuan Gu, Zhen Liu
Summary: In this study, a new strategy called molecularly imprinted nanobeacons (MINBs) was developed to redirect innate immune killing towards triple-negative breast cancer (TNBC). The MINBs tagged TNBC cells by binding with glycoprotein nonmetastatic B (GPNMB) and recruited hapten-specific antibodies to trigger effective immune killing. In vivo experiments showed significant inhibition of TNBC growth after MINBs treatment. This research not only provides a new approach for redirecting innate immunity towards TNBC, but also paves the way for innate immunity-based therapy of other diseases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Oncology
Chiara Corti, Federica Giugliano, Eleonora Nicolo, Liliana Ascione, Giuseppe Curigliano
Summary: Metastatic breast cancer is an incurable disease, with chemotherapy often used alongside endocrine therapy and targeted agents. Antibody-drug conjugates (ADCs) offer a promising approach by combining the selectivity of monoclonal antibodies with the cytotoxic properties of chemotherapy, potentially improving the therapeutic index of anticancer drugs. Some ADCs have shown activity in both HER2-positive and HER2-low breast cancer patients, indicating a bystander effect that may help overcome tumor heterogeneity.
Review
Immunology
Huan-Rong Lan, Min Chen, Shi-Ya Yao, Jun-Xia Chen, Ke-Tao Jin
Summary: Breast cancer is a complex and prevalent disease, and the development of new anticancer therapies is crucial. Bispecific antibodies (BsAbs) that target two different antigens simultaneously have emerged as a promising strategy for breast cancer treatment. By targeting tumor-associated antigens, engaging immune cells, or blocking signaling pathways, BsAbs offer enhanced tumor specificity and immune system involvement, improving treatment outcomes. Combining BsAbs with existing therapies, such as chemotherapy, targeted therapies, or immune checkpoint inhibitors, has also shown synergistic effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kandasamy Saravanakumar, Sathiyaseelan Anbazhagan, Janandi Pujani Usliyanage, Kumar Vishven Naveen, Udari Wijesinghe, Hu Xiaowen, Veeraraghavan Vishnu Priya, Gobika Thiripuranathar, Myeong-Hyeon Wang
Summary: Nanosized drug carriers, specifically immunonanomedicine, have shown promise in targeting cancer cells. Understanding nanotechnology, cancer biology, immunomedicine, and nanoparticle surface chemistry is crucial for the preparation of effective immuno-nanomedicine. Factors such as nanoparticle type and composition, drug loading, size, shape, and ligand conjugation play important roles in cancer cell targeting and drug release. The selection of specific receptors and their ligand is essential for the development of active immuno-nanomedicines. This review focuses on the fundamental factors and technical challenges in the fabrication of antibody alone or drug conjugated nanoparticles for breast cancer treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tinglin Yang, Wenhui Li, Tao Huang, Jun Zhou
Summary: To achieve targeted therapy in breast cancer treatment, antibody-drug conjugates (ADCs) have been developed. ADCs consist of antibodies that target tumor-specific antigens, chemical linkers, and cytotoxic payloads that kill cancer cells effectively. The approval of ado-trastuzumab emtansine (T-DM1) and fam-trastuzumab deruxtecan (T-DXd) has highlighted the therapeutic potential of ADCs in breast cancer. This review summarizes the current and emerging ADC agents and targets, as well as the structure and development history of ADCs. It also discusses the challenges and future directions in this field, providing insights into novel treatments for breast cancer using ADCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Zhihui Dong, Zhuoshan Huang, Senlin Li, Ying Wang, Yandan Yao, Xianzhu Yang, Xiaoding Xu
Summary: Tumor microenvironment (TME) pH-responsive nanoparticles (NPs) were developed for systemic mRNA delivery to reverse trastuzumab resistance in breast cancer. These NPs, consisting of a pH-liable polymer and lipid, could efficiently deliver PTEN mRNA into tumor cells and up-regulate PTEN expression, ultimately blocking the PI3K/Akt signaling pathway and reversing trastuzumab resistance in breast cancer.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Multidisciplinary Sciences
Edward Seung, Zhen Xing, Lan Wu, Ercole Rao, Virna Cortez-Retamozo, Beatriz Ospina, Liqing Chen, Christian Beil, Zhili Song, Bailin Zhang, Mikhail Levit, Gejing Deng, Andrew Hebert, Patrick Kirby, Aiqun Li, Emma-Jane Poulton, Rita Vicente, Audrey Garrigou, Peter Piepenhagen, Greg Ulinski, Michele Sanicola-Nadel, Dinesh S. Bangari, Huawei Qiu, Lily Pao, Dmitri Wiederschain, Ronnie Wei, Zhi-yong Yang, Gary J. Nabel
Summary: A trispecific antibody targeting HER2 and T cells can inhibit breast cancer cell proliferation by stimulating CD4 T cells, and induce tumor regression in a humanized mouse model.
Article
Oncology
Eric D. Routh, Mark G. Woodcock, Wolfgang Beckabir, Steven P. Vensko, Jonathan S. Serody, Benjamin G. Vincent
Summary: The role of B cells in antitumor immunity and response to immunotherapy in patients with breast cancer is being increasingly recognized. This study investigated the antibody responses to tumor antigens in breast cancer patients treated with pembrolizumab and found that signal presence was associated with both neoepitopes and self-peptides. Patient-specific patterns of antibody signal boostability were observed, which were independent of clinical response. The study also highlighted the potential association between antibody boosting and clinical response, particularly in patients with increased levels of IgG specific to a sequence of EPS8 protein.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Veronique Debien, Evandro de Azambuja, Martine Piccart-Gebhart
Summary: Triple-positive breast tumors overexpress HER2 and are positive for HR expression. ER expression affects the response to anti-HER2 and associated systemic therapies. Optimizing dual anti-HER2 blockade is important for disease control in triple-positive tumors.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Changchuan Jiang, Stuthi Perimbeti, Lei Deng, Charles L. L. Shapiro, Shipra Gandhi
Summary: The development of novel anti-HER2 drugs provides new treatment options for breast cancer patients. This study found that HER2-low tumors have a higher prevalence and better survival rates in breast cancer patients, especially when chemotherapy is the first-line treatment.
Article
Multidisciplinary Sciences
Rosalynd Upton, Allison Banuelos, Dongdong Feng, Tanuka Biswas, Kevin Kao, Kelly McKenna, Stephen Willingham, Po Yi Ho, Benyamin Rosental, Michal Caspi Tal, Tal Raveh, Jens-Peter Volkmer, Mark D. Pegram, Irving L. Weissman
Summary: Trastuzumab, a targeted anti-HER2 monoclonal antibody, is effective for early-stage HER2(+) breast cancer but resistance often develops in advanced-stage patients. Combining trastuzumab with anti-CD47 immunotherapy shows promising results in inhibiting the growth of ADCC-tolerant HER2(+) breast cancers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Mireia Berdiel-Acer, Ana Maia, Zhivka Hristova, Simone Borgoni, Martina Vetter, Sara Burmester, Corinna Becki, Birgitta Michels, Khalid Abnaof, Ilona Binenbaum, Daniel Bethmann, Aristotelis Chatziioannou, Max Hasmann, Christoph Thomssen, Elisa Espinet, Stefan Wiemann
Summary: High expression of HER3 in luminal breast cancer subtypes is regulated by NRG1, which is secreted by cancer-associated fibroblasts (CAFs). The study also identifies a HER3-independent NRG1 signaling pathway in CAFs that induces a migratory and pro-fibrotic phenotype. Additionally, Hyaluronan Synthase 2 (HAS2) is identified as a key player supporting NRG1 signaling in CAFs.
Article
Oncology
Otto Metzger Filho, Giuseppe Viale, Shayna Stein, Lorenzo Trippa, Denise A. Yardley, Ingrid A. Mayer, Vandana G. Abramson, Carlos L. Arteaga, Laura M. Spring, Adrienne G. Waks, Eileen Wrabel, Michelle K. DeMeo, Aditya Bardia, Patrizia Dell'Orto, Leila Russo, Tari A. King, Kornelia Polyak, Franziska Michor, Eric P. Winer, Ian E. Krop
Summary: Intratumor heterogeneity, particularly the fraction of ERBB2 nonamplified cancer cells, is strongly correlated with resistance to HER2-targeted therapies and could potentially aid in optimizing treatment selection for HER2-positive breast cancer patients.
Article
Oncology
Juan Carlos Montero, Elisa Calvo-Jimenez, Sofia del Carmen, Mar Abad, Alberto Ocana, Atanasio Pandiella
Summary: This study identified a list of potential ADC targets in TNBC through comparative genomic studies and proteomic analyses, with CD98hc validated as an effective ADC target. The CD98hc ADC efficiently internalized and reached the lysosomal compartment, exhibiting antitumoral properties in TNBC models by blocking cell cycle progression and inducing mitotic catastrophe.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Guilherme Nader-Marta, Chiara Molinelli, Veronique Debien, Diogo Martins-Branco, Philippe Aftimos, Evandro de Azambuja, Ahmad Awada
Summary: Antibody-drug conjugates (ADCs) are a type of antineoplastic agents that combine monoclonal antibodies, cytotoxic payloads, and linkers to create a smart drug delivery system with high specificity and potency. ADCs are internalized by tumor cells and release cytotoxic payloads, leading to cell death. The development of ADCs with additional functional properties allows for activity in neighboring cells without the target antigen, providing a valuable strategy to overcome tumor heterogeneity. Several ADCs have been approved for breast cancer treatment, demonstrating unprecedented efficacy. However, challenges still exist, including the need for reliable biomarkers, management of toxicities, understanding resistance mechanisms, and optimizing treatment sequencing and combinations.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Eunjoo Kim, Gus A. Wright, Roger S. Zoh, Bhimanagouda S. Patil, Guddadarangavvanahally K. Jayaprakasha, Evelyn S. Callaway, Ivan Ivanov, Nancy D. Turner, Robert S. Chapkin
EUROPEAN JOURNAL OF CANCER PREVENTION
(2019)
Article
Genetics & Heredity
Mark F. Richardson, Kylie Munyard, Larry J. Croft, Theodore R. Allnutt, Felicity Jackling, Fahad Alshanbari, Matthew Jevit, Gus A. Wright, Rhys Cransberg, Ahmed Tibary, Polina Perelman, Belinda Appleton, Terje Raudsepp
FRONTIERS IN GENETICS
(2019)
Article
Veterinary Sciences
K. J. Beste, S. D. Lawhon, A. M. Chamoun-Emanuelli, A. H. Duff, M. C. Coleman, C. E. Griffin, J. Hardy, C. M. Whitfield-Cargile
EQUINE VETERINARY JOURNAL
(2020)
Article
Multidisciplinary Sciences
Ana M. Chamoun-Emanuelli, Laura K. Bryan, Noah D. Cohen, Taylor L. Tetrault, Joseph A. Szule, Rola Barhoumi, Canaan M. Whitfield-Cargile
SCIENTIFIC REPORTS
(2019)
Correction
Biochemistry & Molecular Biology
Rudo Simeon, Mengqiu Jiang, Ana M. Chamoun-Emanuelli, Hua Yu, Yongrong Zhang, Ran Meng, Zeyu Peng, Joanita Jakana, Junjie Zhang, Hanping Feng, Zhilei Chen
Article
Biochemical Research Methods
Pete Heinzelman, Alyssa Low, Rudo Simeon, Gus A. Wright, Zhilei Chen
JOURNAL OF BIOLOGICAL ENGINEERING
(2019)
Article
Oncology
Keshav Karki, Gus A. Wright, Kumaravel Mohankumar, Un-Ho Jin, Xing-Han Zhang, Stephen Safe
Article
Genetics & Heredity
Kushal Suryamohan, Sajesh P. Krishnankutty, Joseph Guillory, Matthew Jevit, Markus S. Schroeder, Meng Wu, Boney Kuriakose, Oommen K. Mathew, Rajadurai C. Perumal, Ivan Koludarov, Leonard D. Goldstein, Kate Senger, Mandumpala Davis Dixon, Dinesh Velayutham, Derek Vargas, Subhra Chaudhuri, Megha Muraleedharan, Ridhi Goel, Ying-Jiun J. Chen, Aakrosh Ratan, Peter Liu, Brendan Faherty, Guillermo de la Rosa, Hiroki Shibata, Miriam Baca, Meredith Sagolla, James Ziai, Gus A. Wright, Domagoj Vucic, Sangeetha Mohan, Aju Antony, Jeremy Stinson, Donald S. Kirkpatrick, Rami N. Hannoush, Steffen Durinck, Zora Modrusan, Eric W. Stawiski, Kristen Wiley, Terje Raudsepp, R. Manjunatha Kini, Arun Zachariah, Somasekar Seshagiri
Article
Entomology
Jiaxin Lei, Ivy W. Chen, Gus Wright, Suresh Pillai, Keyan Zhu-Salzman
JOURNAL OF PEST SCIENCE
(2020)
Article
Multidisciplinary Sciences
Michelle C. Coleman, Canaan Whitfield-Cargile, Noah D. Cohen, Jennifer L. Goldsby, Laurie Davidson, Ana M. Chamoun-Emanuelli, Ivan Ivanov, Susan Eades, Nancy Ing, Robert S. Chapkin
Article
Biochemistry & Molecular Biology
Huajun Han, Laurie A. Davidson, Yang-Yi Fan, Jennifer S. Goldsby, Grace Yoon, Un-Ho Jin, Gus A. Wright, Kerstin K. Landrock, Bradley R. Weeks, Rachel C. Wright, Clinton D. Allred, Arul Jayaraman, Ivan Ivanov, Jatin Roper, Stephen H. Safe, Robert S. Chapkin
Article
Multidisciplinary Sciences
Shauna P. Lawless, Noah D. Cohen, Sara D. Lawhon, Ana M. Chamoun-Emanuelli, Jing Wu, Andres Rivera-Velez, Brad R. Weeks, Canaan M. Whitfield-Cargile
Article
Veterinary Sciences
Canaan M. Whitfield-Cargile, Michelle C. Coleman, Noah D. Cohen, Ana M. Chamoun-Emanuelli, Cristobal Navas DeSolis, Taylor Tetrault, Ryan Sowinski, Amanda Bradbery, Mattea Much
Summary: The study found that phenylbutazone may cause gastrointestinal injury in horses, including impaired barrier function and gastric ulcers. Additionally, nutritional treatment could alleviate these changes.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Natalia Rodriguez, Canaan M. Whitfield-Cargile, Ana M. Chamoun-Emanuelli, Elizabeth Hildreth, Will Jordan, Michelle C. Coleman
Summary: Research on nasopharyngeal washes of horses affected with NCS and unaffected horses showed significant differences in fungal microbiota, with the genus Bipolaris being notably increased in horses with NCS, indicating a need for further investigation.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Carmen H. Lau, Drew Pendleton, Nicholas L. Drury, Jiayun Zhao, Yixin Li, Renyi Zhang, Gus A. Wright, Aline Rodrigues Hoffmann, Natalie M. Johnson
Summary: Early life exposure to particulate matter air pollution negatively affects neonatal health. This study evaluated the role of Nrf2 in response to prenatal exposure to ultrafine particles (UFP) and found that the lack of Nrf2 leads to growth inhibitory effects and a skewed immune response towards Th2 in neonates.