Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

(2018) Conglei Li et al.   Nature Communications

Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development

(2017) Xuanying Li et al.   GENES & DEVELOPMENT

Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair

(2017) Vincent Duheron et al.   JOURNAL OF CELL SCIENCE

Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events

(2017) Douglas R. Mackay et al.   JOURNAL OF CELL SCIENCE

SAGA Is a General Cofactor for RNA Polymerase II Transcription

(2017) Tiago Baptista et al.   MOLECULAR CELL

Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module

(2016) Wenqian Li et al.   MOLECULAR AND CELLULAR BIOLOGY

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth

(2016) Boyko S. Atanassov et al.   MOLECULAR CELL

The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation

(2016) Shaliny Ramachandran et al.   Cell Reports

DNA End Resection: Facts and Mechanisms

(2016) Ting Liu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

(2015) Alkmini Kalousi et al.   Cell Reports

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription

(2014) Jacques Bonnet et al.   GENES & DEVELOPMENT

Nuclear position dictates DNA repair pathway choice

(2014) Charlène Lemaître et al.   GENES & DEVELOPMENT

GANP Regulates the Choice of DNA Repair Pathway by DNA-PKcs Interaction in AID-Dependent IgV Region Diversification

(2014) M. M. A. Eid et al.   JOURNAL OF IMMUNOLOGY

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GANP enhances the efficiency of mRNA nuclear export in mammalian cells

(2014) Vihandha O. Wickramasinghe et al.   Nucleus

The human TREX-2 complex is stably associated with the nuclear pore basket

(2013) D. Umlauf et al.   JOURNAL OF CELL SCIENCE

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

(2012) Jacob Falck et al.   EMBO REPORTS

Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export

(2012) Divyang Jani et al.   NUCLEIC ACIDS RESEARCH

The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

(2012) C Lemaître et al.   ONCOGENE

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

mRNA export and gene expression: The SAGA–TREX-2 connection

(2011) Encar García-Oliver et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

(2011) P Moudry et al.   CELL DEATH AND DIFFERENTIATION

RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response

(2011) Yosef Shiloh et al.   FEBS LETTERS

Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation

(2011) V. M. Weake et al.   GENES & DEVELOPMENT

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

(2011) G. Lang et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cells

(2011) O D Shahar et al.   ONCOGENE

Deciphering the chromatin landscape induced around DNA double strand breaks

(2010) Laurent Massip et al.   CELL CYCLE

Multiple faces of the SAGA complex

(2010) Evangelia Koutelou et al.   CURRENT OPINION IN CELL BIOLOGY

The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties

(2010) Jacques Bonnet et al.   EMBO REPORTS

mRNA Export from Mammalian Cell Nuclei Is Dependent on GANP

(2009) Vihandha O. Wickramasinghe et al.   CURRENT BIOLOGY

Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery

(2009) Marius Boulos Faza et al.   JOURNAL OF CELL BIOLOGY

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2

(2008) P. Pascual-Garcia et al.   GENES & DEVELOPMENT

The Human SPT20-Containing SAGA Complex Plays a Direct Role in the Regulation of Endoplasmic Reticulum Stress-Induced Genes

(2008) Z. Nagy et al.   MOLECULAR AND CELLULAR BIOLOGY

The THP1-SAC3-SUS1-CDC31 Complex Works in Transcription Elongation-mRNA Export Preventing RNA-mediated Genome Instability

(2008) Cristina González-Aguilera et al.   MOLECULAR BIOLOGY OF THE CELL

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export

(2008) Alwin Köhler et al.   NATURE CELL BIOLOGY