Targeting tachykinin receptors for the treatment of functional gastrointestinal disorders with a focus on irritable bowel syndrome

Su1160 A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate the Efficacy of 7 Days of Orally Administered Nepadutant in Infants With Colic - the NO-CRY Study

(2015) Sibylle Koletzko et al.   GASTROENTEROLOGY

Mo1056 Weekly Assessment of Satisfactory Relief vs. Quantitative Daily Assessment of Signs and Symptoms in IBS: Do They Provide Comparable Data? the IRIS-2 Study Experience With Ibodutant in IBS-D

(2015) Jan F. Tack et al.   GASTROENTEROLOGY

Effect of Antidepressants and Psychological Therapies, Including Hypnotherapy, in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis

(2014) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome

(2013) Michael Camilleri   EXPERT OPINION ON PHARMACOTHERAPY

Eluxadoline Benefits Patients With Irritable Bowel Syndrome With Diarrhea in a Phase 2 Study

(2013) Leonard S. Dove et al.   GASTROENTEROLOGY

Influence of a neurokinin-1 receptor antagonist (aprepitant) on gastric sensorimotor function in healthy volunteers

(2013) D. Ang et al.   NEUROGASTROENTEROLOGY AND MOTILITY

FDA and EMA end points: which outcome end points should we use in clinical trials in patients with irritable bowel syndrome?

(2013) M. Corsetti et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study

(2012) K. Tillisch et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trial: the clinical effects of a novel neurokinin receptor antagonist, DNK333, in women with diarrhoea-predominant irritable bowel syndrome

(2011) S. Zakko et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Role of tachykinin receptors in the modulation of colonic peristaltic activity in mice

(2011) Annemie Deiteren et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tachykinin NK2 receptor antagonists. A patent review (2006 – 2010)

(2011) Maria Altamura   EXPERT OPINION ON THERAPEUTIC PATENTS

Bidirectional Regulation of Human Colonic Smooth Muscle Contractility by Tachykinin NK2 Receptors

(2011) Akihiro Nakamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation

(2011) Mark Pimentel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A randomized, placebo-controlled, crossover, double-blind trial of the NK1 receptor antagonist aprepitant on gastrointestinal motor function in healthy humans

(2010) J. L. MADSEN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effects of neurokinins on human colonic motility

(2010) C. B. KÖULBEL et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Tachykinin receptor antagonists in clinical trials

(2009) Laura Quartara et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Expression of the tachykinin receptor mRNAs in healthy human colon

(2008) Nadia Jaafari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Qualitative and quantitative analysis of tachykinin NK2 receptors in chemically defined human colonic neuronal pathways

(2008) Nadia Jaafari et al.   JOURNAL OF COMPARATIVE NEUROLOGY