Article
Endocrinology & Metabolism
Yu Feng, Hantao Wang, Zhi Chen, Bin Chen
Summary: Research suggests that high glucose levels in T2D-IDD patients lead to overactivation of glucose transporters and subsequent gene dysregulation, resulting in apoptosis and IDD development. Inhibiting GLUTs can reverse IDD defects caused by high glucose levels.
Article
Cell Biology
David J. Simon, Deanna M. Belsky, Margot E. Bowen, Christine Y. J. Ohn, Melanie K. O'Rourke, Rebecca Shen, Garam Kim, Jason Pitts, Laura D. Attardi, Marc Tessier-Lavigne
Summary: Axon remodeling through sprouting and pruning is important for the refinement of developing neural circuits. Developing sensory axons deprived of neurotrophic support undergo apoptosis, with the tumor suppressor P53 playing a crucial role in activating the apoptotic pathway in axons. P53 appears to act in the cytoplasm to directly activate the mitochondrial apoptotic pathway in axons, highlighting a cytoplasmic role in the anterograde death of developing sensory axons.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Ruiqi Zhu, Li Li, Bao Nguyen, Jaesung Seo, Min Wu, Tessa Seale, Mark Levis, Amy Duffield, Yu Hu, Donald Small
Summary: Combining FLT3 TKIs with BCL-2 selective inhibitors synergistically reduces cell proliferation and enhances apoptosis, resensitizing FLT3 TKI-resistant cells. Venetoclax mitigates the pro-survival effects of FLT3 TKIs by dissociating BIM from BCL-2 and decreasing BIM expression. This study provides evidence that adding BCL-2 inhibitors enhances the efficacy of FLT3 TKI therapy in FLT3/ITD AML treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jian Li, Cheng-Hsun Chen, Katelyn L. O'Neill, Valerie J. Fousek-Schuller, Adrian R. Black, Jennifer D. Black, Jingjing Zhang, Xu Luo
Summary: This study examined the role of the Bcl-2 protein family in AURK inhibitor-induced apoptosis in colon cancer cells. It was found that combining a Bcl-xL inhibitor with an AURK inhibitor effectively induced apoptosis, and several members of the Bcl-2 protein family were identified as mediators of this process.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Hematology
D. Thomalla, L. Beckmann, C. Grimm, M. Oliverio, L. Meder, C. D. Herling, P. Nieper, T. Feldmann, O. Merkel, E. Lorsy, A. da Palma Guerreiro, J. von Jan, I. Kisis, E. Wasserburger, J. Claasen, E. Faitschuk-Meyer, J. Altmueller, P. Nuernberg, T. -P. Yang, M. Lienhard, R. Herwig, K. -A. Kreuzer, C. P. Pallasch, R. Buettner, S. C. Schaefer, J. Hartley, H. Abken, M. Peifer, H. Kashkar, G. Knittel, B. Eichhorst, R. T. Ullrich, M. Herling, H. C. Reinhardt, M. Hallek, M. R. Schweiger, L. P. Frenzel
Summary: This study explores the role of epigenetic events in venetoclax resistance in aggressive lymphoma and high-risk CLL patients. It identifies methylation of a regulatory CpG island within the PUMA promoter as a mechanism for mediating PUMA downregulation and resistance to venetoclax. The loss of PUMA results in metabolic reprogramming and higher oxidative phosphorylation, resembling the metabolic phenotype associated with venetoclax resistance. Additionally, it highlights the critical role of BAX-mediated apoptosis in drug resistance and provides potential therapeutic targets to overcome venetoclax resistance.
Article
Virology
Lin Yang, Chenyu Wang, Jinqi Shu, Huapeng Feng, Yulong He, Jian Chen, Jianhong Shu
Summary: In studying the pathogenic mechanism of PEDV, it was found that PEDV infection can activate Puma and induce apoptosis in a P53-dependent pathway. These findings provide valuable data support for further research on the pathogenic mechanism of PEDV and the development of an effective vaccine against PEDV.
Editorial Material
Biology
Nicole Swann
Summary: A young group leader contemplates on academic culture and working while undergoing cancer treatments.
Correction
Cell Biology
Tobias Sperka, Zhangfa Song, Yohei Morita, Kodandaramireddy Nalapareddy, Luis Miguel Guachalla, Andre Lechel, Yvonne Begus-Nahrmann, Martin D. Burkhalter, Monika Mach, Falk Schlaudraff, Birgit Liss, Zhenyu Ju, Michael R. Speicher, K. Lenhard Rudolph
Summary: A correction to this paper has been published, please refer to the link for details.
NATURE CELL BIOLOGY
(2021)
Review
Plant Sciences
Ana L. Rodas, Edelin Roque, Rim Hamza, Concepcion Gomez-Mena, Jose Pio Beltran, Luis A. Canas
Summary: The SUPERMAN (SUP) gene was originally described in Arabidopsis thaliana and plays a crucial role in regulating stamen and carpel number in flowers. In this article, we summarize the research on SUP orthologs in plant species other than Arabidopsis, with a focus on the legume Medicago truncatula. The MtSUP gene in M. truncatula is involved in the complex genetic network controlling compound inflorescence and flower development in legumes, providing new insights into these processes.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
James M. Pemberton, Justin P. Pogmore, David W. Andrews
Summary: Axonal degeneration and neuronal cell death are regulated by BCL-2 family proteins, with potential influences from other cell death pathways. Deciphering the subsets of proteins required and separately regulating these outcomes is essential for future research and pharmacological interventions.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Engineering, Electrical & Electronic
Adrian Garcia-Rodriguez, David Lopez-Perez, Lorenzo Galati-Giordano, Giovanni Geraci
Summary: Wi-Fi 7 (802.11be) promises a revolution in wireless connectivity with features like multi-AP coordination and coordinated beamforming, expected to achieve near-tenfold reductions in delays.
IEEE COMMUNICATIONS MAGAZINE
(2021)
Editorial Material
Microbiology
Tyler D. Bold
Summary: Two new studies bring both new hope, with a promising ribosome-targeting TB therapy, and a new challenge to overcome, with antibiotic resilience.
CELL HOST & MICROBE
(2023)
Article
Physics, Particles & Fields
E. Fernandez-Martinez, J. Lopez-Pavon, J. M. No, T. Ota, S. Rosauro-Alcaraz
Summary: We perform a comprehensive scan of the parameter space of a singlet scalar extension of the Standard Model and find that bubble nucleation is a fundamental constraint. The allowed parameter space is already significantly probed by constraints on scalar mixing. The addition of new neutrino singlet fields does not drastically alter the parameter space from early universe phenomenology.
EUROPEAN PHYSICAL JOURNAL C
(2023)
Article
Management
Ludwig Dierks, Sven Seuken
Summary: This study analyzes the viability of offering a spot market in cloud computing by combining queueing theory and game theory. The findings show that a provider can achieve a profit increase and create a Pareto improvement for users by offering a spot market alongside a fixed-price market.
MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yang Chen, Nanjing Li, Jun Yang, Ke Li, Mei Tang, Xinyu Zhao, Wenhao Guo, Aiping Tong, Chunlai Nie, Yong Peng, Zhu Yuan
Summary: This study reveals a novel mechanism of PUMA in promoting apoptosis in ovarian cancer by activating ASK1 and subsequently activating the ASK1-JNK axis. Additionally, in vivo experiments demonstrate that PUMA combined with chemotherapy can effectively inhibit the growth of cisplatin-resistant ovarian cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
