Article
Biochemistry & Molecular Biology
Shagufta Parveen, Aneeqa Batool, Nusrat Shafiq, Maryam Rashid, Ayesha Sultan, Gezahign Fentahun Wondmie, Yousef A. Bin Jardan, Simone Brogi, Mohammed Bourhia
Summary: In this study, compounds with antioxidant activity were screened from pomegranate peels for the treatment of Alzheimer's disease. The inhibitory effect of estrogen on Alzheimer's disease and its role in protecting the brain were investigated. Computational calculations and experiments identified hesperidin as a potential candidate for drug discovery.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Nutrition & Dietetics
Dominik Szwajgier, Ewa Baranowska-Wojcik, Anna Winiarska-Mieczan, Dorota Gajowniczek-Alasa
Summary: Alzheimer's disease is a progressive neurodegenerative disease characterized by low levels of acetylcholine, oxidative stress, and inflammation. The current treatment involves the use of acetylcholinesterase inhibitors, but prevention can be achieved by consuming the right inhibitors through food. This study found that different types of honey contain cholinesterase inhibitors, which may play a significant role in Alzheimer's disease.
Article
Multidisciplinary Sciences
David N. Ngai, Cromwell M. Kibiti, Mathew Piero Ngugi
Summary: Alzheimer's disease is a leading cause of death for old people, with approximately 7.7 million new cases per year globally. It is expected that by 2050, 1.5% of the population will be affected by Alzheimer's or other types of dementia. Currently, there is no cure for Alzheimer's and the available therapeutic agents have limited efficacy and serious side effects. This study investigated the cognitive enhancing and anticholinesterase effects of methanol extracts of stem bark and leaf of Prunus africana in mice with induced Alzheimer's disease. The extracts exhibited significant anticholinesterase activities and improved cognition in a dose dependent manner. This study supports the use of P. africana extracts for the management of dementia by traditional herbal practitioners.
Article
Geriatrics & Gerontology
Insiya B. Poonawalla, Yihua Xu, Rainelle Gaddy, Alex James, Matt Ruble, Salina Burns, Suzanne W. Dixon, Brandon T. Suehs
Summary: The use of anticholinergic medications is linked to an increased risk of cognitive decline in the elderly. However, little is known about this association from a health plan perspective.
Article
Chemistry, Multidisciplinary
Hong Jae Cheon, Quynh Huong Nguyen, Moon Il Kim
Summary: Histidine coated magnetic nanoparticles (His@MNPs) were developed with enhanced peroxidase-imitating activity for detecting the neurotransmitter acetylcholine with high sensitivity and reliability. The potential of utilizing His@MNPs as peroxidase-mimicking nanozymes for detecting important biological and clinical targets was demonstrated in this study.
Article
Chemistry, Medicinal
Xueyang Jiang, Chang Liu, Manxing Zou, Huanfang Xie, Tailiang Lin, Weiping Lyu, Jian Xu, Yuan Li, Feng Feng, Haopeng Sun, Wenyuan Liu
Summary: Acetylcholinesterase (AChE) inhibitors are the first-line drugs for Alzheimer's disease treatment approved by the FDA, but their short effective window limits therapeutic benefits. Studies have shown that combining AChE inhibitors with neuroprotective agents results in better anti-AD effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Nancy D. Asen, Ogadimma D. Okagu, Chibuike C. Udenigwe, Rotimi E. Aluko
Summary: This study explores the potential of peptides obtained from enzymatic digestion of pea protein as novel AChE-inhibitory agents in Alzheimer's disease management. The peptides were found to be able to change the conformation of AChE protein and inhibit its activity, making them promising candidates for more effective and safer AD treatments.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Sina Marzoughi, Ankur Banerjee, Catherine R. Jutzeler, Marco A. M. Prado, Jan Rosner, Jacquelyn J. Cragg, Neil Cashman
Summary: The cholinergic system is a complex neurotransmitter system involved at multiple levels of the nervous system. Anticholinergic medications, commonly prescribed, have been linked to dementia and may impact cerebral vasculature and neuroinflammation, potentially contributing to progression of neurodegenerative diseases. Long-term use of these medications has detrimental effects beyond short-term cognitive impairment, affecting cholinergic neurotransmission and receptors on immune cells and vasculature.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Katarzyna M. Targowska-Duda, Maciej Maj, Piotr Draczkowski, Barbara Budzynska, Anna Boguszewska-Czubara, Tomasz M. Wrobel, Tuomo Laitinen, Patrycja Kaczmar, Antti Poso, Agnieszka A. Kaczor
Summary: The study used structure-based virtual screening and molecular dynamics simulation to identify potential acetylcholinesterase inhibitors from the Enamine database. Through experimental validation and analysis, several promising compounds for acetylcholinesterase inhibition were discovered.
Article
Biochemistry & Molecular Biology
K. Pavani, D. S. N. B. K. Prasanth, Murthy K. R. Shadakshara, Sheikh F. Ahmad, Ramanjaneyulu Seemaladinne, Mithun Rudrapal, Praveen Kumar Pasala
Summary: The study evaluated the inhibitory effects of Citronellal (CTN) on Acetylcholine esterase (AChE) using computational chemistry approaches. The results suggested that CTN may serve as a potential antioxidant and neuroprotective supplement.
Article
Pharmacology & Pharmacy
Ahmed I. Foudah, Sushma Devi, Aftab Alam, Mohammad Ayman Salkini, Samir A. Ross
Summary: Alzheimer's disease (AD) is a form of dementia characterized by cognitive decline and behavior changes, which is caused by factors including amyloid-beta accumulation and acetylcholine loss. This study investigated the effects of resveratrol (RES) alone and in combination with vitamin E on rats with AD induced by scopolamine. The results showed that RES and vitamin E had beneficial effects on cognitive impairment and neuroprotection in AD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Roland Nicsanu, Carlo Cervellati, Luisa Benussi, Rosanna Squitti, Roberta Zanardini, Valentina Rosta, Alessandro Trentini, Clarissa Ferrari, Claudia Saraceno, Antonio Longobardi, Sonia Bellini, Giuliano Binetti, Orazio Zanetti, Giovanni Zuliani, Roberta Ghidoni
Summary: This study investigated the role of serum BACE1 activity as a biomarker for Alzheimer's disease (AD). Results showed that BACE1 levels were increased in AD and MCI-AD patients and could accurately discriminate patients with high sensitivity and specificity. High BACE1 levels were associated with worse cognitive performance and earlier disease onset.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Yash Pal Singh, Harish Kumar
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by memory impairment and decline in thinking ability. The exact cause of the disease is not fully understood, but factors like low acetylcholine levels, aggregation of A beta peptide, hyperphosphorylation of tau, bio-metal imbalance, and oxidative stress play a role. Currently, there is no specific treatment available, and the development of new drug candidates is urgently needed.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Federico Licastro, Elisa Porcellini
Summary: Chronic neurodegenerative diseases are influenced by various complex factors, including viral infections, brain inflammation, and genetic factors, which may contribute to the development of diseases such as Alzheimer's. Prevention and intervention measures may be beneficial for elderly individuals with genetic susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Susmita Chandramouleeshwaran, Naba Ahsan, Roger Raymond, Jose N. Nobrega, Wei Wang, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, Sanjeev Kumar, Krista Lanctot, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji
Summary: This study introduces a new assay to measure serum anticholinergic activity and finds associations with cognitive assessments and anticholinergic burden rating scales in older patients with mild cognitive impairment or major depressive disorder.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)