AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral Sclerosis

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

(2015) L. Palamiuc et al.   EMBO Molecular Medicine

Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis

(2015) Yu-Ju Liu et al.   FEBS LETTERS

“Preconditioning” with latrepirdine, an adenosine 5′-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1G93A mice

(2015) Karen S. Coughlan et al.   NEUROBIOLOGY OF AGING

Potential Therapeutic Drugs and Methods for the Treatment of Amyotrophic Lateral Sclerosis

(2014) G. Yacila et al.   CURRENT MEDICINAL CHEMISTRY

Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis

(2014) Yu-Ju Liu et al.   HUMAN MOLECULAR GENETICS

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

(2014) Maria A. Lim et al.   HUMAN MOLECULAR GENETICS

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apoptosis in a mouse model of amyotrophic lateral sclerosis

(2014) Dongsheng Fan et al.   Neural Regeneration Research

Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

(2014) Nirma D. Perera et al.   PLoS One

Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model

(2014) Csilla Ari et al.   PLoS One

Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration

(2013) Á T Behan et al.   CELL DEATH AND DIFFERENTIATION

PGC-1  is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis

(2013) J. Eschbach et al.   HUMAN MOLECULAR GENETICS

The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

(2013) Wenzhang Wang et al.   HUMAN MOLECULAR GENETICS

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis

(2013) Pablo M. Peixoto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Adipose Tissue Distribution Predicts Survival in Amyotrophic Lateral Sclerosis

(2013) Eva Lindauer et al.   PLoS One

Systemic Down-Regulation of Delta-9 Desaturase Promotes Muscle Oxidative Metabolism and Accelerates Muscle Function Recovery following Nerve Injury

(2013) Ghulam Hussain et al.   PLoS One

TDP-43, an ALS Linked Protein, Regulates Fat Deposition and Glucose Homeostasis

(2013) Nancy R. Stallings et al.   PLoS One

Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis

(2013) J. C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reducing systemic hypermetabolism by inducing hypothyroidism does not prolong survival in the SOD1-G93A mouse

(2012) Jia Li et al.   Amyotrophic Lateral Sclerosis

Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS

(2012) Sandrine Da Cruz et al.   Cell Metabolism

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats

(2012) Cao Huang et al.   HUMAN MOLECULAR GENETICS

Malonyl-CoA: the regulator of fatty acid synthesis and oxidation

(2012) Daniel W. Foster   JOURNAL OF CLINICAL INVESTIGATION

Reduced Activity of AMP-Activated Protein Kinase Protects against Genetic Models of Motor Neuron Disease

(2012) M. A. Lim et al.   JOURNAL OF NEUROSCIENCE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

(2012) Wei Zhao et al.   PLoS One

Premorbid body mass index and risk of amyotrophic lateral sclerosis

(2012) Éilis J. O'Reilly et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Early and Progressive Impairment of Spinal Blood Flow—Glucose Metabolism Coupling in Motor Neuron Degeneration of ALS Model Mice

(2011) Kazunori Miyazaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

(2011) Wei Zhao et al.   Molecular Neurodegeneration

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

(2011) Huiyun Liang et al.   MUSCLE & NERVE

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

(2011) Arunabh Bhattacharya et al.   NEUROBIOLOGY OF AGING

Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1G93A Mouse Model of ALS and Is Harmful in Female Mice

(2011) Hannah M. Kaneb et al.   PLoS One

A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS

(2010) Ali Jawaid et al.   Amyotrophic Lateral Sclerosis

Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice

(2010) Daniel J. Amante et al.   Amyotrophic Lateral Sclerosis

Impaired glucose tolerance in patients with amyotrophic lateral sclerosis

(2010) Pierre-Francois Pradat et al.   Amyotrophic Lateral Sclerosis

Extensive FUS-Immunoreactive Pathology in Juvenile Amyotrophic Lateral Sclerosis with Basophilic Inclusions

(2010) Eric J. Huang et al.   BRAIN PATHOLOGY

ALS disease onset may occur later in patients with pre-morbid diabetes mellitus

(2010) A. Jawaid et al.   EUROPEAN JOURNAL OF NEUROLOGY

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

(2010) Jun Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cold pre-conditioning neuroprotection depends on TNF-α and is enhanced by blockade of interleukin-11

(2010) Heidi M. Mitchell et al.   JOURNAL OF NEUROCHEMISTRY

Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis

(2010) J. Dorst et al.   JOURNAL OF NEUROLOGY

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

(2010) Y.-F. Xu et al.   JOURNAL OF NEUROSCIENCE

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Caloric Restriction Shortens Lifespan through an Increase in Lipid Peroxidation, Inflammation and Apoptosis in the G93A Mouse, an Animal Model of ALS

(2010) Barkha P. Patel et al.   PLoS One

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

(2010) P.-M. Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice

(2010) X. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of AMP-activated protein kinase

(2009) J. S. Oakhill et al.   Acta Physiologica

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

(2009) Jeroen Poels et al.   BIOESSAYS

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Hypermetabolism in ALS patients: an early and persistent phenomenon

(2009) C. Bouteloup et al.   JOURNAL OF NEUROLOGY

Do patients with amyotrophic lateral sclerosis (ALS) have increased energy needs?

(2009) Nachum Vaisman et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons

(2009) Luc Dupuis et al.   PLoS One

Are statin medications safe in patients with ALS?

(2008) Lorne Zinman et al.   Amyotrophic Lateral Sclerosis

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

(2008) L. Dupuis et al.   NEUROLOGY

An evaluation of a data mining signal for amyotrophic lateral sclerosis and statins detected in FDA's spontaneous adverse event reporting system

(2008) Eric Colman et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY