Article
Biochemistry & Molecular Biology
Liana Marengo, Fred Armbrust, Caroline Schoenherr, Steffen E. Storck, Ulrich Schmitt, Silvia Zampar, Oliver Wirths, Hermann Altmeppen, Markus Glatzel, Christoph Kaether, Sascha Weggen, Christoph Becker-Pauly, Claus U. Pietrzik
Summary: This study reports the generation of a transgenic mouse model of AD lacking the functional Mep1b gene (APP/lon x Mep1b(-/-)). The results showed that when meprin beta is absent, the levels of A beta 1-40 and 1-42 are reduced in APP/lon mice, and the deposition of N-terminally truncated A beta 2-x peptide is also decreased. Importantly, the loss of meprin beta improved cognitive abilities in APP/lon mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaojing Zhou, Abdullah Md. Sheikh, Ken-ichi Matsumoto, Shingo Mitaki, Abu Zaffar Shibly, Yuchi Zhang, A. Garu, Shozo Yano, Atsushi Nagai
Summary: Through proteomic analysis of urine exosomes in AD model mice, we identified proteins related to lipid metabolism and A beta metabolism in the early stages of AD, providing new insights into the underlying pathological mechanism of early AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Jiang Chen, Anran Fan, Song Li, Yan Xiao, Yanlin Fu, Jun-Sheng Chen, Dan Zi, Ling-Hui Zeng, Jun Tan
Summary: Alzheimer's disease (AD), the most common type of dementia, is characterized by the presence of extracellular senile plaques composed of beta-amyloid peptides and intracellular neurofibrillary tangles containing phosphorylated-tau protein. This study has demonstrated the interaction between soluble tau and the N-terminal of amyloid precursor protein (APP) in vitro and in vivo, as well as the involvement of APP in the cellular uptake of tau through endocytosis. Targeting the pathological interaction between N-terminal APP and tau could be a promising therapeutic strategy for AD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuki Kobayashi, Shogo Kohbuchi, Noriko Koganezawa, Yuko Sekino, Tomoaki Shirao, Takaomi C. Saido, Takashi Saito, Yumiko Saito
Summary: The primary cilium, a sensory organelle extending from cell bodies, plays a crucial role in neuronal integrity and connectivity. Research suggests a potential link between the structural alterations of neuronal cilia and the development of Alzheimer's disease and ciliopathies, which are characterized by memory and cognitive impairments.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Clinical Neurology
Shang Wang, Taiyang Zhu, Wanyan Ni, Chao Zhou, Hui Zhou, Li Lin, Yuting Hu, Xiaoyu Sun, Jingjing Han, Yan Zhou, Guoliang Jin, Jie Zu, Hongjuan Shi, Xingxing Yang, Zuohui Zhang, Fang Hua
Summary: This study investigates the role of early activation of Toll-like receptor 3 (TLR3) in the pathophysiological process of Alzheimer's disease (AD). The results showed that the early activation of TLR3 attenuated neuronal loss and neurobehavioral dysfunction in a mouse model of AD. This could be attributed to its role in A beta clearance, the inhibition of glial cells, and the regulation of neuroinflammation in the hippocampus.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Guilian Xu, Brittany S. Ulm, John Howard, Susan E. Fromholt, Qing Lu, Brian Benedict Lee, Ariel Walker, David R. Borchelt, Jada Lewis
Summary: The study aims to investigate the pathological interaction between amyloidosis and tauopathy in Alzheimer's disease, and found that the development of tauopathy is exacerbated by the presence of newly forming amyloid deposits in younger brains and mature deposits in older brains.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Neurosciences
Henrique Correia Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Talita Glaser, Milena da Silva Milanis, Christiane Gimenes, Deborah Suchecki, Ricardo Mario Arida, Henning Ulrich, Beatriz Monteiro Longo
Summary: The aim of this study was to investigate the effects of resistance exercise on preventing and recovering from AD-related neuropathological conditions in APP/PS1 mice. The results showed that 4 weeks of resistance exercise improved locomotor activity and memory in APP/PS1 mice, and reduced A beta plaques and systemic inflammation. These findings suggest that resistance exercise plays a role in alleviating AD symptoms and can be an effective complementary treatment for AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Laura Schnoeder, Wenqiang Quan, Ye Yu, Inge Tomic, Qinghua Luo, Wenlin Hao, Guoping Peng, Dong Li, Klaus Fassbender, Yang Liu
Summary: In the brains of Alzheimer's disease (AD) mice, deficiency of IKK beta in neurons reduces levels of amyloid-beta-peptide (Aβ) and phosphorylated tau (p-tau), modifies inflammatory activation, and improves cognitive function. The deficiency also decreases BACE1 protein and activity, increases expression of PP2A isoform A, and enhances autophagy. However, the protective effects of IKK beta deficiency differ in APP and tau-transgenic mice. Further studies are needed to understand the interaction between Aβ and p-tau before targeting IKK beta/NF-kappa B for AD therapies.
Article
Biochemical Research Methods
Soumya Kandi, Erika N. Cline, Brianna M. Rivera, Kirsten L. Viola, Jiuhe Zhu, Carlo Condello, Richard D. Leduc, William L. Klein, Neil L. Kelleher, Steven M. Patrie
Summary: This study focuses on the role of different proteoforms of A beta in Alzheimer's disease. The authors evaluated the flux of A beta proteoforms using quantitative top-down mass spectrometry in a mouse model. They found 25 different forms of A beta with differential solubility in addition to the major A beta 1-42 form. These proteoforms were categorized into three groups based on expression levels and solubility. The findings suggest that this workflow has potential for investigating the relationship between insoluble fibrils and soluble A beta, as well as the role of low-molecular-weight oligomers in neurotoxicity. It may also help validate the use of AD-relevant animal models.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bjorn Johansson, Sho Oasa, Aida Muntsant Soria, Ann Tiiman, Linda Soderberg, Ebba Amandius, Christer Moller, Lars Lannfelt, Lars Terenius, Lydia Gimenez-Llort, Vladana Vukojevic
Summary: Traditional fluorescence microscopy has limited spatial resolution, while electron microscopy lacks molecular specificity and has limited field of view. The use of STED microscopy with fluorescently labeled antibodies enables visualization of amyloidogenic aggregates with sub-diffraction limited spatial resolution. This advancement is crucial for understanding the etiology of Alzheimer's disease and developing anti-amyloid treatments.
CELL AND BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
E. Sandra Chocron, Erin Munkacsy, Harper S. Kim, Przemyslaw Karpowicz, Nisi Jiang, Candice E. Van Skike, Nicholas DeRosa, Andy Q. Banh, Juan P. Palavicini, Pawel Wityk, Leszek Kalinowski, Veronica Galvan, Pawel A. Osmulski, Elzbieta Jankowska, Maria Gaczynska, Andrew M. Pickering
Summary: The proteasome plays a key role in neuronal proteostasis and its dysfunction is associated with Alzheimer's disease. Preventing proteasome dysfunction delays mortality, cell death, and cognitive deficits in AD models. Activating proteasome activity through peptidomimetics protects against cell death, cognitive decline, and mortality in AD models.
Article
Neurosciences
Rachel R. Corrigan, Luis Labrador, John Grizzanti, Megan Mey, Helen Piontkivska, Gemma Casadesus
Summary: The study aims to investigate the role of pancreatic amylin peptide in metabolic regulation and its relationship with Alzheimer's disease. The results show that amylin improves cognitive function, while inhibiting amylin receptors increases the risk of Alzheimer's disease. Additionally, there are different neuroprotective mechanisms in response to amylin therapy between females and males.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Arnold M. Salazar, Amanda M. Leisgang, Andrew A. Ortiz, Andrew S. Murtishaw, Jefferson W. Kinney
Summary: The study demonstrates altered GABAergic signaling in an amyloid model of AD, with changes in GABA-related targets associated with disease-related memory and learning deficits.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Amaya Urdanoz-Casado, Javier Sanchez-Ruiz de Gordoa, Maitane Robles, Miren Roldan, Monica Macias Conde, Blanca Acha, Idoia Blanco-Luquin, Maite Mendioroz
Summary: Alzheimer's disease (AD) is the most common cause of age-related dementia. It has been found that a circular RNA (circRNA) derived from the APP gene may contribute to the synthesis of A beta peptides, providing an alternative pathway for A beta biogenesis. In this study, we investigated the expression of a circAPP (hsa_circ_0007556) in the entorhinal cortex of AD patients, and observed decreased levels of circAPP (hsa_circ_0007556) in AD cases compared to controls. We also found a negative correlation between A beta deposits and circAPP (hsa_circ_0007556) and APP expression levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Patrick H. Luckett, Charlie Chen, Brian A. Gordon, Julie Wisch, Sarah B. Berman, Jasmeer P. Chhatwal, Carlos Cruchaga, Anne M. Fagan, Martin R. Farlow, Nick C. Fox, Mathias Jucker, Johannes Levin, Colin L. Masters, Hiroshi Mori, James M. Noble, Stephen Salloway, Peter R. Schofield, Adam M. Brickman, William S. Brooks, David M. Cash, Michael J. Fulham, Bernardino Ghetti, Clifford R. Jack, Jonathan Voeglein, William E. Klunk, Robert Koeppe, Yi Su, Michael Weiner, Qing Wang, Daniel Marcus, Deborah Koudelis, Nelly Joseph-Mathurin, Lisa Cash, Russ Hornbeck, Chengjie Xiong, Richard J. Perrin, Celeste M. Karch, Jason Hassenstab, Eric McDade, John C. Morris, Tammie L. S. Benzinger, Randall J. Bateman, Beau M. Ances
Summary: This study analyzed 19 biomarkers of Alzheimer's disease using hierarchical clustering and feature selection, and found that amyloid and tau measures were the primary predictors. Emerging biomarkers of neuronal integrity and inflammation showed weaker predictive ability.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Erin Halley Squillacote Drazich-Taylor, Emily Todd, Rhian Convery, Martina Bocchetta, Mica Clarke, Jason D. Warren, Nick C. Fox, Tamas Revesz, Jonathan Daniel Rohrer
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric McDade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen
Summary: This study found that plasma GFAP levels increase a decade before symptom onset in AD and are associated with Aβ load, neurodegeneration, and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Douglas T. Leffa, Joao Pedro Ferrari-Souza, Bruna Bellaver, Cecile Tissot, Pamela C. L. Ferreira, Wagner S. Brum, Arthur Caye, Jodie Lord, Petroula Proitsi, Thais Martins-Silva, Luciana Tovo-Rodrigues, Dana L. Tudorascu, Victor L. Villemagne, Ann D. Cohen, Oscar L. Lopez, William E. Klunk, Thomas K. Karikari, Pedro Rosa-Neto, Eduardo R. Zimmer, Brooke S. G. Molina, Luis Augusto Rohde, Tharick A. Pascoal
Summary: The genetic liability for attention-deficit/hyperactivity disorder (ADHD) is associated with cognitive decline and the development of Alzheimer's Disease (AD) pathology, especially in individuals with increased amyloid-beta (Aβ) deposition.
MOLECULAR PSYCHIATRY
(2023)
Article
Cell Biology
Stephanie Schultz, Zahra P. Shirzadi, Aaron Schultz, Lei D. Liu, Colleen Fitzpatrick, Eric R. McDade, Nicolas Barthelemy, Alan Renton, Bianca Esposito, Nelly Joseph-Mathurin, Carlos D. Cruchaga, Charles Chen, Alison Goate, Ricardo Francisco Allegri, Tammie L. S. Benzinger, Sarah C. Berman, Helena M. Chui, Anne R. Fagan, Martin C. Farlow, Nick A. Fox, Brian S. Gordon, Gregory R. Day, Neill J. Graff-Radford, Jason J. Hassenstab, Bernard Hanseeuw, Anna R. Hofmann, Clifford R. Jack Jr, Mathias M. Jucker, Celeste A. Karch, Robert Koeppe, Jae-Hong I. Lee, Allan Levey, Johannes N. Levin, Ralph Martins, Hiroshi C. Mori, John Morris, James J. Noble, Richard Perrin, Pedro P. Rosa-Neto, Stephen Salloway, Raquel R. Sanchez-Valle, Peter Schofield, Chengjie A. Xiong, Keith J. Johnson, Randall A. Bateman, Reisa P. Sperling, Jasmeer Chhatwal
Summary: In individuals with autosomal-dominant Alzheimer disease (ADAD) caused by pathogenic variants in PSEN1, there is significant variability in the rates of cognitive decline and biomarker change. This study found that the location of the pathogenic variant within PSEN1 may contribute to this interindividual variability. Specifically, variants affecting the transmembrane domain of PSEN1 were associated with greater cognitive impairment, smaller hippocampal volume, and elevated phosphorylated tau levels compared to variants affecting the cytoplasmic domain.
Article
Geriatrics & Gerontology
Jemma Hazan, Simon Hall, Alex Pemberton, Ian Sherriffs, Suzanne Joels, Amanda Heslegrave, Elena Veleva, Mamoona Ghauri, Rhiannon Laban, Emily Abel, Henrik Zetterberg, Nick C. C. Fox, Robert Howard
Summary: This study explored the utility of plasma phosphorylated-tau181 (p-tau181) as a blood-based biomarker for Alzheimer's disease pathology. The results showed that 86% of clinicians found the p-tau181 result to be helpful and 44% of cases found it useful in making the diagnosis. However, further education and training are needed for clinicians to understand and interpret ambiguity in biomarker results.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Neurosciences
Jemma Hazan, Kathy Y. Liu, Nick Fox, Robert Howard
Summary: Changes in diagnostic certainty can be evaluated by assessing the impact of a diagnostic test in driving decision making. Diagnostic tests can be appraised using validated measures of accuracy, i.e., sensitivity, specificity, and positive or negative predictive values against a known reference standard. However, other less well formalized factors affect diagnostic certainty.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Ellen Grober, Kellen K. Petersen, Richard B. Lipton, Jason Hassenstab, John C. Morris, Brian A. Gordon, Ali Ezzati
Summary: This study used the SOMI system to identify individuals with subtle cognitive impairment among those who appear to be cognitively normal. The results showed that participants with retrieval impairment (SOMI-1) had a higher incidence of cognitive impairment, and the risk increased even more for those with storage impairment (SOMI-3/4), after adjusting for demographics and APOE ε4 status. Additionally, the study found that SOMI remained a significant predictor of incident cognitive impairment even after considering biomarkers of β-amyloid, tau pathology, and neurodegeneration.
Article
Clinical Neurology
Sigan L. Hartley, Benjamin Handen, Dana Tudorascu, Laisze Lee, Annie Cohen, Emily K. Schworer, Jamie C. Peven, Matthew Zammit, William Klunk, Charles Laymon, Davneet Minhas, Weiquan Luo, Shahid Zaman, Beau Ances, Gregory Preboske, Bradley T. Christian
Summary: This study investigates the AT(N) biomarker characteristics in Down syndrome (DS). The findings suggest that Tau PET (T+) is closely associated with memory impairment and AD clinical status in DS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Matthew D. Zammit, Tobey J. Betthauser, Andrew K. Mcvea, Charles M. Laymon, Dana L. Tudorascu, Sterling C. Johnson, Sigan L. Hartley, Alexander K. Converse, Davneet S. Minhas, Shahid H. Zaman, Beau M. Ances, Charles K. Stone, Chester A. Mathis, Annie D. Cohen, William E. Klunk, Benjamin L. Handen, Bradley T. Christian
Summary: Understanding the trajectories of AD biomarkers in individuals with Down syndrome (DS) is crucial for clinical interventions and interpretation of drug-related changes.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Sigan L. Hartley, Victoria Fleming, Emily K. Schworer, Jamie Peven, Benjamin L. Handen, Sharon Krinsky-McHale, Christy Hom, Laisze Lee, Dana L. Tudorascu, Charles Laymon, Davneet Minhas, Weiquan Luo, Annie Cohen, Shahid Zaman, Beau M. Ances, Mark Mapstone, Elizabeth Head, Florence Lai, H. Diana Rosas, William Klunk, Bradley Christian
Summary: This study aimed to investigate whether premorbid intellectual disability level was associated with the variability in age-trajectories of Alzheimer's disease biomarkers and cognitive impairments. The results showed no significant effect of premorbid intellectual disability level on the trajectories of Alzheimer's disease biomarkers and cognitive outcomes.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Editorial Material
Clinical Neurology
Christopher R. S. Belder, Jonathan M. Schott, Nick C. Fox
Article
Biochemistry & Molecular Biology
Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric McDade, Nicolas R. Barthelemy, Celeste M. Karch, Chengjie Xiong, Carlos Cruchaga, Richard J. Perrin, Aliza P. Wingo, Thomas S. Wingo, Jasmeer P. Chhatwal, Gregory S. Day, James M. Noble, Sarah B. Berman, Ralph Martins, Neill R. Graff-Radford, Peter R. Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin Farlow, James J. Lah, Christian Haass, Mathias Jucker, John C. Morris, Tammie L. S. Benzinger, Blaine R. Roberts, Randall J. Bateman, Anne M. Fagan, Nicholas T. Seyfried, Allan Levey
Summary: Alzheimer's disease pathology, characterized by aggregation of Aβ peptide into plaques and tau protein into neurofibrillary tangles, develops years before cognitive symptoms. By analyzing cerebrospinal fluid proteomics in individuals with autosomal dominant AD, researchers identified protein changes associated with Aβ plaques and their temporal evolution over six decades. These proteomic measurements were able to differentiate mutation carriers from noncarriers before symptom onset better than traditional Aβ and tau measures. Understanding the multifaceted landscape of AD pathology and its progression is crucial for developing precise therapeutic interventions and biomarkers.
Article
Neurosciences
Nicole S. McKay, Brian A. Gordon, Russ C. Hornbeck, Aylin Dincer, Shaney Flores, Sarah J. Keefe, Nelly Joseph-Mathurin, Clifford R. Jack, Robert Koeppe, Peter R. Millar, Beau M. Ances, Charles D. Chen, Alisha Daniels, Diana A. Hobbs, Kelley Jackson, Deborah Koudelis, Parinaz Massoumzadeh, Austin McCullough, Michael L. Nickels, Farzaneh Rahmani, Laura Swisher, Qing Wang, Ricardo F. Allegri, Sarah B. Berman, Adam M. Brickman, William S. Brooks, David M. Cash, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Christian la Fougere, Nick C. Fox, Michael Fulham, Bernardino Ghetti, Neill Graff-Radford, Takeshi Ikeuchi, William Klunk, Jae-Hong Lee, Johannes Levin, Ralph Martins, Colin L. Masters, Jonathan McConathy, Hiroshi Mori, James Noble, Gerald Reischl, Christopher Rowe, Stephen Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Hiroyuki Shimada, Mikio Shoji, Yi Su, Kazushi Suzuki, Jonathan Voeglein, Igor Yakushev, Carlos Cruchaga, Jason Hassenstab, Celeste Karch, Eric McDade, Richard J. Perrin, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger
Summary: The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration that studies autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations in three genes. Non-carrier siblings from ADAD families can be recruited for case-control studies. The predictable age of onset in ADAD allows for mapping candidate AD biomarkers during the preclinical phase. This study provides valuable data for understanding early disease stages of both ADAD and sporadic AD, as well as for research in healthy aging.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Joao Pedro Ferrari-Souza, Bruna Bellaver, Pamela C. L. Ferreira, Andrea L. Benedet, Guilherme Povala, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cecile Tissot, Carolina Soares, Yi-Ting Wang, Mira Chamoun, Stijn Servaes, Arthur C. Macedo, Marie Vermeiren, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, Ann Cohen, Oscar L. Lopez, William E. Klunk, Jean-Paul Soucy, Serge Gauthier, Diogo O. Souza, Gallen Triana-Baltzer, Ziad S. Saad, Hartmuth C. Kolb, Thomas K. Karikari, Victor L. Villemagne, Dana L. Tudorascu, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Pedro Rosa-Neto, Tharick A. Pascoal
Summary: The APOE ε4 allele enhances the long-term effects of Aβ protein on the phosphorylated accumulation of tau protein, which may be mediated by the increased longitudinal plasma phosphorylated tau protein at threonine 217. This long-term accumulation of tau protein is accompanied by brain atrophy and clinical progression.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)