Article
Rheumatology
Yudong Liu, Changsheng Xia, Jiali Chen, Chunhong Fan, Jing He
Summary: Active AOSD is associated with elevated levels of a pro-inflammatory subset of neutrophils, the LDGs that produce IL-6. LDGs are significantly correlated with disease activity and laboratory parameters in AOSD, as well as serum IL-6 levels.
Article
Cell Biology
Muhammad G. T. Ahmed, Andreas Limmer, Matthias Hartmann
Summary: Inflammation regulates the expression of CD45 in leukocytes, and this study investigated the effect of inflammation on the expression of CD45 subtypes in different cell types. The results showed that CD45RA expression was reduced in granulocytes of postoperative and septic patients, while CD45RO expression was reduced in lymphocytes. The diagnostic and pathophysiologic implications of these findings should be further studied.
Article
Immunology
Sonia Y. Velasquez, Anna Coulibaly, Carsten Sticht, Jutta Schulte, Bianka Hahn, Timo Sturm, Roman Schefzik, Manfred Thiel, Holger A. Lindner
Summary: Infection can induce granulopoiesis, which potentially contributes to the development of blood gene classifiers for sepsis in SIRS patients. This study aimed to identify signature genes of blood granulocytes in sepsis and SIRS patients on ICU admission. The expression of certain genes involved in granulocytic differentiation was found to be elevated in sepsis patients compared to SIRS patients, suggesting that these genes could be used as classifiers for sepsis in SIRS patients. However, further research is needed to distinguish this process from granulopoiesis induced by noninfectious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Noorisah Khan, Supreet Kaur, Carly M. Knuth, Marc G. Jeschke
Summary: Severe burn-induced inflammation and subsequent hypermetabolic response can result in infection, sepsis, and multiple organ failure, posing high mortality risks for patients. Restoring immune balance, particularly through modulation of the CNS-spleen axis, has shown promising benefits in improving clinical outcomes. Targeting the CNS-spleen axis to regulate inflammation appears to be crucial for recovery in burn patients and other hyperinflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Kibum Jeon, Nuri Lee, Seri Jeong, Min-Jeong Park, Wonkeun Song
Summary: The study evaluated the effectiveness of IG% as an independent prognostic indicator of sepsis, finding that IG% < 4% had low predictability, but increased thereafter. The interaction plot of IG% and C-reactive protein showed an increase in sepsis probability at an IG% of 6% and C-reactive protein of 160 mg/L.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Astrid Fabri, Khalil Kandara, Remy Coudereau, Morgane Gossez, Paul Abraham, Celine Monard, Martin Cour, Thomas Rimmele, Laurent Argaud, Guillaume Monneret, Fabienne Venet
Summary: The study analyzed the impact of IL-10 production in septic patients' whole blood, revealing monocytes and CD4+ T cells as the main IL-10 producers associated with global immunosuppression in septic shock. Further research is needed to determine the pathophysiological mechanisms leading to increased IL-10 production in monocytes and CD4+ T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Sarah Cattin, Benoit Fellay, Antonello Calderoni, Alexandre Christinat, Laura Negretti, Maira Biggiogero, Alberto Badellino, Anne-Lise Schneider, Pelagia Tsoutsou, Alessandra Franzetti Pellanda, Curzio Ruegg
Summary: This study revealed changes in blood leukocytes associated with primary BC, surgical removal, and adjuvant radiotherapy, including increased levels of CD117(+) granulocytes, memory, and regulatory CD4(+) T cells. Unsupervised analysis of flow cytometry data revealed new cell populations associated with BC or radiotherapy.
BREAST CANCER RESEARCH
(2021)
Article
Critical Care Medicine
Carly M. Knuth, Sarah Rehou, Dalia Barayan, Marc G. Jeschke
Summary: Sepsis has become the leading cause of death in burn patients, leading to significant morbidity and longer hospitalization. However, sepsis in burn patients is poorly understood. This study compared clinical, metabolic, and inflammatory markers in septic and nonseptic burn patients using different sepsis definitions, and identified temporal biomarker alterations that could improve sepsis diagnosis accuracy in burn patients.
Article
Immunology
Chaojin Chen, Rongzong Qiu, Jing Yang, Qian Zhang, Guoliang Sun, Xiaofeng Gao, Ziqing Hei, Haocong Ji
Summary: The study demonstrates that LXA4 can attenuate septic AKI by blocking the crosstalk between inflammation and premature senescence, thus restoring renal function and improving survival rate. Premature senescence plays a critical role in septic AKI, and inhibiting the crosstalk between inflammation and premature senescence may represent a new and major mechanism by which LXA4 attenuates septic AKI.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Rui Wang, Jinglin Zhao, Qi Wei, Hao Wang, Chao Zhao, Caihong Hu, Yu Han, Zhi Hui, Long Yang, Qingchun Dai, Cuicui Liu
Summary: The study found that the expression of blood lncRNA CASC2 was decreased in sepsis patients, and it was associated with severe multi-organ dysfunction and increased mortality.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, Research & Experimental
Breanne H. Y. Gibson, Colby C. Wollenman, Stephanie N. Moore-Lotridge, Patrick R. Keller, J. Blair Summitt, Alexey R. Revenko, Matthew J. Flick, Timothy S. Blackwell, Jonathan G. Schoenecker
Summary: Severe injury induces systemic inflammatory response syndrome (SIRS), with early activation of plasmin playing a key role in driving SIRS. Plasmin activation is associated with injury severity, SIRS, coagulopathy, and mortality. Targeted inhibition of plasmin activation may be effective in limiting both hemorrhage and tissue-damaging inflammation after injury.
Article
Multidisciplinary Sciences
Xanthe Brands, Fabrice Uhel, Lonneke A. van Vught, Maryse A. Wiewel, Arie J. Hoogendijk, Rene Lutter, Marcus J. Schultz, Brendon P. Scicluna, Tom van der Poll
Summary: The objective of this study was to investigate the relationship between immune suppression and systemic inflammation in ICU patients. The results showed that the degree of immune suppression was associated with increasing systemic inflammation. These findings have relevance for selecting patients eligible for immune enhancing agents.
Article
Immunology
Mile Stanojcic, Roohi Vinaik, Abdikarim Abdullahi, Peter Chen, Marc G. Jeschke
Summary: The activation of NLRP3 inflammasome enhances tissue-specific inflammatory responsiveness in burn sepsis, leading to improved bacterial clearance and survival rates in animal models. However, Nlrp3 genetic ablation paradoxically increases acute immune infiltration and inflammation, potentially impacting patient outcomes in septic burn patients.
Article
Cell Biology
Chan Mo, Shuwen Xie, Bin Liu, Weichao Zhong, Ting Zeng, Sha Huang, Yuqi Lai, Guanghui Deng, Chuying Zhou, Weixin Yan, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv
Summary: The study demonstrates that IDO1 affects the recruitment of immune cells by inhibiting DCs maturation and subsequent T cell proliferation, exacerbating the progression of liver fibrosis. Targeting IDO1 to ameliorate immune responses in the hepatic and splenic microenvironment may be essential for therapeutic effects on liver fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Ioannis Stratos, Ann-Kathrin Behrendt, Christian Anselm, Aldebarani Gonzalez, Thomas Mittlmeier, Brigitte Vollmar
Summary: The study found that TNF-alpha blockade may help promote recovery after muscle injury, positively impacting the repair of muscle tissue and reducing tissue degradation.