Lipoxin A4 Restores Septic Renal Function via Blocking Crosstalk Between Inflammation and Premature Senescence

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

15-Epi-LXA4and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

(2020) Meriem Sekheri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa induces cellular senescence in lung tissue at the early stage of two-hit septic mice

(2019) Hui Li et al.   Pathogens and Disease

Astroglia in Sepsis Associated Encephalopathy

(2019) Tatyana Shulyatnikova et al.   NEUROCHEMICAL RESEARCH

NAD+ metabolism governs the proinflammatory senescence-associated secretome

(2019) Timothy Nacarelli et al.   NATURE CELL BIOLOGY

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors

(2019) Jan Korbecki et al.   INFLAMMATION RESEARCH

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

Aerosol inhalation of a hydrogen-rich solution restored septic renal function

(2019) Weifeng Yao et al.   Aging-US

Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure

(2019) Bochra Tourki et al.   Molecular Metabolism

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

Senescence Alters PPARγ (Peroxisome Proliferator–Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors InflammationHighlights

(2018) Anaïs Briot et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion

(2018) Qijian Li et al.   LIFE SCIENCES

Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model

(2018) Haley C. Dunn et al.   JOURNAL OF ALZHEIMERS DISEASE

Cellular senescence: Molecular mechanisms and pathogenicity

(2018) Wenqiang Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation

(2018) Julie Chao et al.   Oxidative Medicine and Cellular Longevity

Pro-resolving lipid mediators: Agents of anti-ageing?

(2018) Ross Doyle et al.   SEMINARS IN IMMUNOLOGY

Signal transduction involved in lipoxin A4-induced protection of tubular epithelial cells against hypoxia/reoxygenation injury

(2017) Sheng-Hua Wu et al.   Molecular Medicine Reports

Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in D-galactose-induced aging rats

(2017) Chao Liu et al.   Clinical Interventions in Aging

Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition

(2016) Benedict Wu et al.   FASEB JOURNAL

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Recent knowledge on the pathophysiology of septic acute kidney injury: A narrative review

(2016) Hoi-Ping Shum et al.   JOURNAL OF CRITICAL CARE

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

The aging kidney revisited: A systematic review

(2014) Davide Bolignano et al.   AGEING RESEARCH REVIEWS

Severity of sepsis-induced acute kidney injury in a novel mouse model is age dependent*

(2012) Bert Maddens et al.   CRITICAL CARE MEDICINE

Lipoxin A4 Increases Survival by Decreasing Systemic Inflammation and Bacterial Load in Sepsis

(2011) Jean Walker et al.   SHOCK

Synthesis of Lipoxin A4 by 5-Lipoxygenase Mediates PPAR -Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke

(2009) M. Sobrado et al.   JOURNAL OF NEUROSCIENCE