Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Vitamin D Deficiency Promotes Human Breast Cancer Growth in a Murine Model of Bone Metastasis

(2010) L. L. Ooi et al.   CANCER RESEARCH

Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer

(2010) Karen M. Bussard et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases

(2010) Daniele Santini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

(2010) Tomoyuki Igawa et al.   NATURE BIOTECHNOLOGY

Humanized Anti-Interleukin-6 Receptor Antibody Suppresses Tumor Angiogenesis and In vivo Growth of Human Oral Squamous Cell Carcinoma

(2009) S. Shinriki et al.   CLINICAL CANCER RESEARCH

Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells

(2008) T. Ara et al.   CANCER RESEARCH