Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

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PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures

(2011) Carmen Huesa et al.   BONE

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(2011) Dwight A. Towler et al.   CIRCULATION RESEARCH

Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate

(2011) Catherine M. Shanahan et al.   CIRCULATION RESEARCH

Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization

(2011) Alexander N. Kapustin et al.   CIRCULATION RESEARCH

Fast docking using the CHARMM force field with EADock DSS

(2011) Aurélien Grosdidier et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum

(2011) Thomas C. Markello et al.   MOLECULAR GENETICS AND METABOLISM

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The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells

(2011) Dongxing Zhu et al.   PLoS One

Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick

(2010) Vicky E. MacRae et al.   BONE

Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: A unified model of the mechanisms of initiation of skeletal calcification

(2010) Manisha C Yadav et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Assay Format as a Critical Success Factor for Identification of Novel Inhibitor Chemotypes of Tissue-Nonspecific Alkaline Phosphatase from High-Throughput Screening

(2010) Thomas D.Y. Chung et al.   MOLECULES

High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action

(2010) Eduard A Sergienko et al.   Nature Protocols

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition

(2009) Ritsuko Nakano-Kurimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Discovery and Validation of a Series of Aryl Sulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP)

(2009) Russell Dahl et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin

(2009) Mohga M. El-Abbadi et al.   KIDNEY INTERNATIONAL

Cardiovascular risk factors in patients with chronic kidney disease

(2009) Sarina van der Zee et al.   Nature Reviews Cardiology

Plasma pyrophosphate and vascular calcification in chronic kidney disease

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Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)

(2008) Shyama Sidique et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis

(2008) Rukshana C. Shroff et al.   CIRCULATION

Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: Potential mechanism for uremic vascular calcification

(2008) K.A. Lomashvili et al.   KIDNEY INTERNATIONAL