期刊
CIRCULATION RESEARCH
卷 108, 期 11, 页码 1378-1380出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.110.234419
关键词
arteriosclerosis; atherosclerosis; vascular calcification; calcific aortic stenosis; review
资金
- National Institutes of Health [HL069229, HL081138, HL088651, HL081202]
- Barnes-Jewish Hospital Foundation
Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once considered only a passive process of dead and dying cells, data from multiple laboratories worldwide have converged to demonstrate that vascular calcification is a highly regulated form of biomineralization. The goal of this thematic review series is to highlight what is known concerning the biological players and game rules with respect to vascular mineral metabolism. Armed with this understanding, it is hoped that novel therapeutic strategies can be crafted to prevent and treat vascular calcium accrual, to the benefit of our patients afflicted with arteriosclerotic valvular and vascular diseases. (Circ Res. 2011; 108: 1378-1380.)
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