Article
Pharmacology & Pharmacy
Wei Xiao, Zehui He, Weikang Luo, Dandan Feng, Yang Wang, Tao Tang, Ali Yang, Jiekun Luo
Summary: Intracerebral hemorrhage (ICH) induces inflammatory response that affects brain repair and organism recovery. Research suggests that Buyang Huanwu Decoction (BYHWD) can attenuate the inflammatory response during ICH recovery in rats by inhibiting the NIK-mediated noncanonical NF-kappa B signaling pathway, improving neurological function in rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Kayo Mori, Akiko Mizokami, Tomomi Sano, Satoru Mukai, Fumitaka Hiura, Yasunori Ayukawa, Kiyoshi Koyano, Takashi Kanematsu, Eijiro Jimi
Summary: The study suggests that activation of the non-canonical NF-kappa B pathway through elevation of serum RANKL levels contributes to postmenopausal obesity.
JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Gastroenterology & Hepatology
Qianhui Chen, Xinyu Lu, Xiaoyong Zhang
Summary: The noncanonical NF-kappa B signaling pathway plays a crucial role in regulating inflammation and immune response, showing potential therapeutic value against liver diseases. Activation of this pathway may contribute to viral clearance, with specific inhibitors and antibodies currently under development and testing.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Virology
Thomas Charles Bisom, Hope Smelser, Jean-Marc Lanchy, J. Stephen Lodmell
Summary: The noncanonical NF-κB pathway, originally involved in lymphoid organogenesis, has shown increased importance in innate immunity in the past 20 years. RNA viruses have been found to activate and exploit this pathway, especially in disrupting transcription of type 1 interferon. This study demonstrates that alternative splicing of RIOK3 mRNA is associated with activation of the noncanonical NF-κB pathway, which is co-opted by RVFV (MP12) to enhance viral success during infection.
Article
Multidisciplinary Sciences
Sevval Nur Bilgic, Aylin Domaniku, Batu Toledo, Samet Agca, Bahar Z. C. Weber, Dilsad H. Arabaci, Zeynep Ozornek, Pascale Lause, Jean-Paul Thissen, Audrey Loumaye, Serkan Kir
Summary: Skeletal muscle atrophy is a common problem in patients with cancer, leading to poor survival and reduced quality of life. The mechanisms behind this muscle wasting are still not fully understood, making it difficult to develop effective therapies.
Review
Biochemistry & Molecular Biology
Eijiro Jimi, Takenobu Katagiri
Summary: The NF-kappa B transcription factor family plays important roles in inflammation, immune response, and bone metabolism. Its activation occurs through different pathways and is crucial for osteoclast differentiation. Recent studies have identified genetic mutations in NF-kappa B signaling molecules associated with diseases like osteopetrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu
Summary: In this study, Epinephelus coioides soluble TLR5 (TLR5S) was identified as a negative regulator of the NF-kappa B signaling pathway. TLR5S specifically responded to Vibrio flagellin and inhibited flagellin-induced activation of NF-kappa B signaling and cytokine expression. This discovery provides insights into the negative regulation of immune signaling and the restoration of homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Xin Liu, Shenglin Zhang, Yi Dong, Yunpeng Xie, Qingshan Li
Summary: Gliomas, the most common primary brain tumors in adults, present clinical challenges due to their infiltrative growth patterns and high relapse tendencies. This study identified SENP1 as an upregulated SUMOylation regulator in gliomas and demonstrated its association with poor prognoses. Mechanistically, SENP1 inhibited SIRT1 expression through de-SUMOylation, leading to the activation of NF-kappa B and promotion of glioma cell malignant phenotype. This suggests that SENP1-mediated de-SUMOylation of SIRT1 could have therapeutic implications for gliomas.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Immunology
Tong Feng, Qiao-feng Wu
Summary: This review discusses the role of NF-κB in the pathogenesis of osteoarthritis and how ncRNAs participate in and affect the incidence and progression of OA, offering novel potential therapeutic options for OA treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chang Shu, Jun Chen, Meiyan Lv, Yiyuan Xi, Jujia Zheng, Xiangwei Xu
Summary: Plumbagin may attenuate RA-induced damage to cells and joints by down-regulating the levels of inflammatory cytokines and MMPs through inhibiting the activation of the NF-kappa B pathway.
Article
Pharmacology & Pharmacy
Lijuan Huang, Yijie Shi, Liang Zhao
Summary: The study found that GB can significantly improve the learning and memory ability of VD rats by reducing TLR4/NF-kappa B mediated neuroinflammation, suggesting that GB may be a potential drug for amelioration of learning and memory impairment in rats with VD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Summary: This study demonstrated for the first time the protective medicinal efficacy of cepharanthine (CEP) in osteoarthritis. CEP suppressed inflammation and increased protein expression in joint tissues while restoring cellular autophagy. The mouse model confirmed the therapeutic potential of CEP in osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Anabel Gonzalez-Gil, Ryan N. Porell, Steve M. Fernandes, Eila Maenpaa, T. August Li, Tong Li, Philip C. Wong, Kazuhiro Aoki, Michael Tiemeyer, Zaikuan J. Yu, Benjamin C. Orsburn, Namandje N. Bumpus, Russell T. Matthews, Ronald L. Schnaar
Summary: Alzheimer's disease is characterized by misfolded proteins, and microglia play a key role in its development. CD33, an inhibitory microglial receptor, is associated with susceptibility to Alzheimer's disease. The ligand RPTP zeta(S3L) is found to be related to the progression of Alzheimer's disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Cangyou Xie, Michiko Satake-Ozawa, Fatma Rashed, Masud Khan, Masaomi Ikeda, Shunya Hayashi, Shinichi Sawada, Yoshihiro Sasaki, Tohru Ikeda, Yoshiyuki Mori, Kazunari Akiyoshi, Kazuhiro Aoki
Summary: The osteoconductive capacity of a newly synthesized CHPA nanogel using OP3-4 and BMP-2 was investigated, and the difference between perforated and nonperforated CHPA nanogels was clarified. The data suggest that perforated CHPA nanogel can induce local bone formation with OP3-4 and BMP-2, and the appropriate degradation rate is important for bone formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yusaku Sugiura, Kazuhiko Sakuma, Shimpei Fujita, Kazuhiro Aoki, Yuji Takazawa
Summary: This study aims to examine the impact of muscle fatigue on hamstring injury prevention programs in sprinters. The results demonstrate that inducing muscle fatigue through a small number of runs can enhance the effectiveness of hamstring injury prevention programs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Yoshimitsu Kohmura, Koya Suzuki, Sawako Wakui, Makoto Nakadake, Yasuhiro Kudo, Kazuhiro Aoki
Summary: The study revealed significant differences in physical fitness among different types of athletes, with gymnasts showing higher flexibility, volleyball players displaying taller height and excellent agility and vertical jumping ability.
GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
(2022)
Article
Ophthalmology
Shigeki Murakami, Yoshimitsu Kohmura, Yuki Someya, Koya Suzuki, Kenji Inoue, Shiro Amano, Kazuhiro Aoki
Summary: In this study, the prevalence of dry eye syndrome (DES) and associated factors were evaluated separately in male and female graduates of physical education and sports science. The findings showed that DES was highly prevalent in both sexes, particularly among those in their 20 and 30s. Contact lens use was associated with DES in both men and women. Measures to address correctable factors may have a positive impact on ocular health and quality of life for physical education and sports science graduates.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Engineering, Biomedical
Hitomi Matsuno, Bin Li, Hisami Okawara, Yusuke Toyoshima, Cangyou Xie, Masud Khan, Natsuko Murakami, Kazuhiro Aoki, Noriyuki Wakabayashi
Summary: In this study, the hypothesis that the alveolar bone proper regulates cellular and functional changes in osteoclasts and osteoblasts through tensile and compressive stresses was tested. Male mice were subjected to vertical loading for 8 or 15 days, and the results showed that osteoclast counts and bone formation were significantly higher at regions with higher stress levels. This finding is crucial for the advancement of clinical dentistry in terms of diagnosis and treatment planning.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Sae Tanaka, Kazuhiro Aoki, Kazuharu Arakawa
Summary: This study developed an in vivo expression system for tardigrades, enabling the introduction of GFP-fused proteins and genetically encoded indicators into tardigrade cells for fluorescence live imaging. The results showed tissue-specific expression of anhydrobiosis-related genes and suggested the regulation of gene expression changes in desiccation-induced species. This technology opens up possibilities for exploring anhydrobiosis mechanisms in tardigrade research.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Cangyou Xie, Fatma Rashed, Yosuke Sasaki, Masud Khan, Jia Qi, Yuri Kubo, Yoshiro Matsumoto, Shinichi Sawada, Yoshihiro Sasaki, Takashi Ono, Tohru Ikeda, Kazunari Akiyoshi, Kazuhiro Aoki
Summary: This study compared the osteoconductivity of two different gels in bone formation induced by RANKL-binding peptide and BMP-2, and found that CHP-A hydrogel was more suitable than CHP-OA hydrogel for peptide-accelerated bone formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Hilary Scott, Boris Novikov, Berrak Ugur, Brooke Allen, Ilya Mertsalov, Pedro Monagas-Valentin, Melissa Koff, Sarah Baas Robinson, Kazuhiro Aoki, Raisa Veizaj, Dirk J. Lefeber, Michael Tiemeyer, Hugo Bellen, Vladislav Panin
Summary: Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. The sialylation pathway, involving CSAS and SiaT genes, functions in the nervous system of Drosophila, affecting neural transmission and excitability. CSAS is restricted to glia, while DSiaT functions in neurons, allowing for regulation of neural functions via a glia-mediated control of neural sialylation. The sialylation genes are required for tolerance to heat and oxidative stress and for maintenance of the normal level of voltage-gated sodium channels.
Article
Biotechnology & Applied Microbiology
Chloe M. Wu, Kelsey M. Wheeler, Gerardo Carcamo-Oyarce, Kazuhiro Aoki, Abigail McShane, Sujit S. Datta, Jessica L. Mark Welch, Michael Tiemeyer, Ann L. Griffen, Katharina Ribbeck
Summary: Human microbiome composition is influenced by the natural host environment, specifically mucus, which contains gel-forming glycoproteins (mucins) with regulatory functions. Mucin glycans enable the coexistence of diverse microbes and prevent disease-associated compositional shifts. Different glycosylation patterns of mucins shape microbial communities by providing nutrients, organizing spatial structure, and potentially limiting competition. This study highlights the importance of mucin glycans as a host mechanism and potential therapeutic approach for maintaining a healthy microbiome.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Cell & Tissue Engineering
Shunsuke Takeuchi, Shunsuke Fukuba, Munehiro Okada, Kohei Nohara, Ryo Sato, Daichi Yamaki, Takanori Matsuura, Shu Hoshi, Kazuhiro Aoki, Takanori Iwata
Summary: This study compared the periodontal regeneration of one-wall intrabony defects treated with open flap debridement, fi-tricalcium phosphate, and carbonate apatite in dogs. The results demonstrated that carbonate apatite has a better ability to integrate with bone, promoting new bone and cementum formation. Therefore, carbonate apatite is a safe and effective option for periodontal regeneration in one-wall intrabony defects in dogs.
REGENERATIVE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Julie Takagi, Kazuhiro Aoki, Bradley S. Turner, Sabrina Lamont, Sylvain Lehoux, Nicole Kavanaugh, Megha Gulati, Ashley Valle Arevalo, Travis J. Lawrence, Colin Y. Kim, Bhavya Bakshi, Mayumi Ishihara, Clarissa J. Nobile, Richard D. Cummings, Daniel J. Wozniak, Michael Tiemeyer, Rachel Hevey, Katharina Ribbeck
Summary: The O-glycans in mucins can inhibit filamentation and infection-related phenotypes of Candida albicans, suggesting their therapeutic potential in managing fungal pathogens.
NATURE CHEMICAL BIOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Yohei Tsukamoto, Kazuhiro Aoki, Yoshiki Narimatsu, Yusuke Urata, Wataru Saiki, Michael Tiemeyer, Henrik Clausen, Yuki Kurebayashi, Akira Minami, Tadanobu Takahashi, Tetsuya Okajima, Hideyuki Takeuchi
Letter
Biochemistry & Molecular Biology
Masae Hosoda, Kazuhiro Aoki, Yann Guerardel, Issaku Yamada, Kiyoko F. Aoki-Kinoshita
Article
Sport Sciences
Yuta Takanashi, Yoshimitsu Kohmura, Kazuhiro Aoki
Summary: This study aimed to assess the explosive muscle performance of the upper body in athletes using various measurement parameters and examine their relationship with athletic performance. The results showed a significant positive correlation between medicine ball throw and athletic performance, while push up jump and countermovement push up were not associated with performance. Additionally, one repetition maximum of the bench press did not show a significant correlation with athletic performance. Athletes are advised to choose events where their weight positively affects their competitive ability and incorporate explosive muscle performance without counter movements in their physical fitness assessment.
JOURNAL OF HUMAN SPORT AND EXERCISE
(2022)