Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease

The role of innate immune genes in Alzheimer's disease

(2021) Ana Griciuc et al.   CURRENT OPINION IN NEUROLOGY

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Nanoparticles Displaying Allergen and Siglec-8 Ligands Suppress IgE-FcεRI–Mediated Anaphylaxis and Desensitize Mast Cells to Subsequent Antigen Challenge

(2021) Shiteng Duan et al.   JOURNAL OF IMMUNOLOGY

CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion

(2021) Claire Ann Butler et al.   JOURNAL OF NEUROCHEMISTRY

Probing the binding specificities of human Siglecs by cell-based glycan arrays

(2021) Christian Büll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s Disease Genetics: A Dampened Microglial Response?

(2021) Zena K. Chatila et al.   NEUROSCIENTIST

CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity

(2021) Vanessa Aires et al.   Frontiers in Immunology

Siglec Ligands

(2021) Anabel Gonzalez-Gil et al.   Cells

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

ISOLATION, IDENTIFICATION AND CHARACTERIZATION OF THE HUMAN AIRWAY LIGAND FOR THE EOSINOPHIL AND MAST CELL IMMUNOINHIBITORY RECEPTOR SIGLEC-8

(2020) Anabel Gonzalez-Gil et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Shifting paradigms: The central role of microglia in Alzheimer's disease

(2020) Tina Schwabe et al.   NEUROBIOLOGY OF DISEASE

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

(2020) Joseph W. Lewcock et al.   NEURON

Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

(2020) Nader Morshed et al.   Molecular Systems Biology

CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen

(2019) Shiteng Duan et al.   JOURNAL OF CLINICAL INVESTIGATION

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Keratan sulfate, a complex glycosaminoglycan with unique functional capability

(2018) Bruce Caterson et al.   GLYCOBIOLOGY

Quantitative Assessment of Urea In-Solution Lys-C/Trypsin Digestions Reveals Superior Performance at Room Temperature over Traditional Proteolysis at 37 °C

(2018) Lazaro Hiram Betancourt et al.   JOURNAL OF PROTEOME RESEARCH

Core Concept: Perineuronal nets gain prominence for their role in learning, memory, and plasticity

(2018) Helen H. Shen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties

(2017) Huifeng Yu et al.   GLYCOBIOLOGY

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8

(2016) Johannes M. Pröpster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

(2016) Tong Li et al.   Nature Communications

Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation

(2013) Takumi Kiwamoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Galactose 6-O-Sulfotransferases Are Not Required for the Generation of Siglec-F Ligands in Leukocytes or Lung Tissue

(2013) Michael L. Patnode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Biosynthesis of the major brain gangliosides GD1a and GT1b

(2012) Elizabeth R Sturgill et al.   GLYCOBIOLOGY

Sialoadhesin in recognition of self and non-self

(2012) Mariliis Klaas et al.   Seminars in Immunopathology

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

(2011) K. Lunnon et al.   JOURNAL OF IMMUNOLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Golgi Glycosylation

(2011) P. Stanley   Cold Spring Harbor Perspectives in Biology

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

(2010) Huan Cao et al.   IMMUNOLOGY

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS