Article
Endocrinology & Metabolism
Elizabeth Shane, Stephanie Shiau, Robert R. Recker, Joan M. Lappe, Sanchita Agarwal, Mafo Kamanda-Kosseh, Mariana Bucovsky, Julie Stubby, Adi Cohen
Summary: The study assessed the effects of denosumab in premenopausal women who completed a 24-month teriparatide treatment. Results showed statistically significant increases in bone mineral density at various sites after denosumab treatment following teriparatide, supporting the sequential use in increasing BMD in severe osteoporosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Multidisciplinary
Sung-Woo Kim, Myong-Won Seo, Hyun-Chul Jung, Jong-Kook Song
Summary: The study showed that four months of high-impact weight-bearing exercise did not significantly improve BMD and bone metabolic markers in middle-aged premenopausal women, but may prevent age-associated changes in bone turnover markers.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Paula P. B. Silva, Rosa M. R. Pereira, Liliam Takayama, Clarissa G. Borba, Felipe H. Duarte, Ericka B. Trarbach, Regina Matsunaga Martin, Marcello D. Bronstein, Nicholas A. Tritos, Raquel S. Jallad
Summary: Acromegaly patients show abnormalities in bone microstructure, bone density, and vertebral fractures, with significant differences in sclerostin and DKK1 compared to the healthy control group, indicating a potential role of Wnt inhibitors in bone microstructure impairment in acromegaly.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Paula P. B. Silva, Rosa M. R. Pereira, Liliam Takayama, Clarissa G. Borba, Felipe H. Duarte, Ericka B. Trarbach, Regina Matsunaga Martin, Marcello D. Bronstein, Nicholas A. Tritos, Raquel S. Jallad
Summary: The study evaluated the impact of isolated GH/IGF-I hypersecretion on bone turnover markers, microarchitecture, and vertebral fractures in female patients with acromegaly. Results showed increased cortical BMD, impaired trabecular bone microstructure, and increased VF in acromegaly patients. Sclerostin was not correlated with HR-pQCT parameters, while DKK1 was correlated with cortical porosity in the tibia. Additional studies are needed to clarify the role of Wnt inhibitors on bone microarchitecture impairment in acromegaly.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Yong-Sheng Lan, Yu-Juan Feng
Summary: Long-term brisk walking is an efficient way to improve bone mineral density in premenopausal women. Brisk walking with a volume greater than 16 times per week is recommended for preventing bone loss.
Article
Sport Sciences
Katherine Brooke-Wavell, Dawn A. Skelton, Karen L. Barker, Emma M. Clark, Sarah De Biase, Susanne Arnold, Zoe Paskins, Katie R. Robinson, Rachel M. Lewis, Jonathan H. Tobias, Kate A. Ward, Julie Whitney, Sarah Leyland
Summary: Exercise and physical activity can improve bone strength and reduce the risk of falls in people with osteoporosis. Resistance and impact exercise, activities to improve strength and balance, and spinal extension exercise are recommended to optimize bone strength, reduce falls, and improve posture. The benefits of physical activity generally outweigh the risks.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Sport Sciences
Horacio Sanchez-Trigo, Carol Maher, Job G. Godino, Borja Sanudo
Summary: This study evaluated the effects of a non-supervised exercise program delivered and monitored through wearable technology and an mHealth app on bone mineral density (BMD). The intervention group showed significant improvements in BMD and physical fitness measures compared to the control group, suggesting the potential of this intervention for osteoporosis prevention.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Chemistry, Multidisciplinary
Petr Kutac, Marek Buzga, Steriani Elavsky, Vaclav Bunc, Daniel Jandacka, Miroslav Krajcigr
Summary: The study found that an increased volume of weekly physical activity is associated with lower body fat in premenopausal women, but appears to have no effect on fat-free mass.
APPLIED SCIENCES-BASEL
(2021)
Article
Nutrition & Dietetics
Adashi Margaret Odama, Valerie Otti, Shuai Xu, Olamide Adebayo, Adetunji T. Toriola
Summary: This study found no associations of coffee and caffeinated tea intake with mammographic breast density in premenopausal women. However, decaffeinated tea may be positively associated with VPD in non-Hispanic white women and was not associated with African American women. Coffee intake was positively associated with dense volume in African American women, but not in non-Hispanic white women.
Article
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Stergios Papachatzopoulos, Polyzois Makras, Athina Gkiomisi, Panagiotis Nikolakopoulos, Stergios A. Polyzos, Charikleia Ntenti, Iris Ballaouri, Spyridon Gerou, Olga Tsachouridou, Athanasios Papatheodorou, Konstantinos Aliazis, Sofia Fermanoglou, Ilias Bisbinas, Maria P. Yavropoulou
Summary: Goserelin-induced menstrual cessation leads to bone loss and changes in bone turnover and expression of bone-related miRNAs, which are only partially reversed six months after menstrual restoration.
Article
Rheumatology
Noha A. Elsawy, Rim A. Mohamed, Rasha A. Ghazala, Mennatullah A. Abdelshafy, Rehab Elnemr
Summary: The serum level of anti-CarP Abs is significantly higher in premenopausal women with RA compared to healthy controls, and is positively correlated with RA disease activity, disability, fatigue, and bone loss. Anti-CarP Abs are associated with decreased physical activity and systemic trabecular bone loss in premenopausal RA women.
Article
Medicine, General & Internal
Rehana Rahman, Ali Usman, Aisha Sheikh, Rozeena Baig
Summary: Cytokines and bone turnover markers were found to be significantly higher in post-menopausal women compared to pre-menopausal women. However, a negative correlation of TNF alpha with BMD was observed in premenopausal women, whereas no significant association of BMD was detected in post-menopausal women.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and with lower BV/TV. A new BMA parameter, Ad.N/BS, is positively correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while that of metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and lower BV/TV. The new BMA parameter Ad.N/BS is correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ronak Bhatt, Sunit Kumar Jurel, Pooran Chand, Neeti Solanki, Kaushal Kishor Agrawal, Shyam Pyari Jaiswar, Amit Arya
Summary: This study compared satisfaction levels and occlusal force with complete dentures between premenopausal and postmenopausal Indian women, showing significantly higher satisfaction and occlusal force in the premenopausal group.
JOURNAL OF PROSTHETIC DENTISTRY
(2022)
Article
Endocrinology & Metabolism
Julia H. Goedecke, Kim A. Nguyen, Clement Kufe, Maphoko Masemola, Tinashe Chikowore, Amy E. Mendham, Shane A. Norris, Nigel J. Crowther, Fredrik Karpe, Tommy Olsson, Andre Pascal Kengne, Lisa K. Micklesfield
Summary: This study demonstrates for the first time that the IDF Europid WC thresholds are not appropriate for an African population, and African-specific WC thresholds perform better than the IDF Europid thresholds to predict incident dysglycaemia and T2D.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Celia L. Gregson, Tafadzwa Madanhire, Andrea Rehman, Rashida A. Ferrand, Anne R. Cappola, Steven Tollman, Tshepiso Mokoena, Lisa K. Micklesfield, Alisha N. Wade, June Fabian
Summary: The study found that osteoporosis is more common than sarcopenia among aging individuals in rural South Africa, with older women living with HIV experiencing greater bone loss. This raises concerns over future fracture risk in Southern Africa, highlighting the importance of routine bone health assessments in HIV clinics, especially for aging women.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Palwende Romuald Boua, Jean-Tristan Brandenburg, Ananyo Choudhury, Hermann Sorgho, Engelbert A. Nonterah, Godfred Agongo, Gershim Asiki, Lisa Micklesfield, Solomon Choma, Francesc Xavier Gomez-Olive, Scott Hazelhurst, Halidou Tinto, Nigel J. Crowther, Christopher G. Mathew, Michele Ramsay
Summary: This study performs a genome-wide association study for carotid intima-media thickness in sub-Saharan African populations, identifying population-specific and sex-specific loci. The study also replicates previous associations found in European populations.
NATURE COMMUNICATIONS
(2022)
Review
Public, Environmental & Occupational Health
Louise Foley, Anna Brugulat-Panes, James Woodcock, Ishtar Govia, Ian Hambleton, Eleanor Turner-Moss, Ebele R. Mogo, Alice Charity Awinja, Philip M. Dambisya, Sostina Spiwe Matina, Lisa Micklesfield, Safura Abdool Karim, Lisa Jayne Ware, Marshall Tulloch-Reid, Felix Assah, Caitlin Pley, Nadia Bennett, Georgina Pujol-Busquets, Kufre Okop, Tanmay Anand, Camille M. Mba, Haowen Kwan, Gudani Mukoma, Megha Anil, Lambed Tatah, Lee Randall
Summary: This study examines the socioeconomic and gender differences in travel behavior in Africa and finds that travel inequity perpetuates socioeconomic and gender disadvantages. Lower socioeconomic individuals rely more on walking and informal public transport, while women and girls face more travel constraints and risks.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Endocrinology & Metabolism
Clement N. Kufe, Lisa K. Micklesfield, Maphoko Masemola, Tinashe Chikowore, Andre P. Kengne, Fredrik Karpe, Shane A. Norris, Nigel J. Crowther, Tommy Olsson, Julia H. Goedecke
Summary: Despite higher rates of overweight/obesity in Black South African women, the prevalence of type 2 diabetes does not differ between genders. This study found that men had lower insulin sensitivity and beta-cell function compared to women, and the association between adiposity and diabetes risk was stronger in men. These findings suggest that Black African men are at greater risk for type 2 diabetes with increasing adiposity.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Ananyo Choudhury, Jean-Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwende Romuald Boua, Nigel J. Crowther, Godfred Agongo, Gershim Asiki, F. Xavier Gomez-Olive, Isaac Kisiangani, Eric Maimela, Matshane Masemola-Maphutha, Lisa K. Micklesfield, Engelbert A. Nonterah, Shane A. Norris, Hermann Sorgho, Halidou Tinto, Stephen Tollman, Sarah E. Graham, Cristen J. Willer, Scott Hazelhurst, Michele Ramsay
Summary: Genetic associations and polygenic scores for lipid traits have limited transferability to African individuals. However, this study demonstrates that larger datasets and better global representation in discovery GWAS can help bridge this gap. The researchers identified a novel LDL-C association and a triglyceride association signal in African populations, supporting the importance of including African data in lipid trait studies. The study also found that the transferability of signals improves with an increase in the size of the African replication cohort.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Gudani Mukoma, Stephanie Wrottesley, Juliana Kagura, Tolu Oni, Lisa Micklesfield, Shane A. Norris
Summary: This study examined the relationship between socioeconomic status (SES), dietary knowledge and patterns, and physical activity level with body mass index (BMI) in urban South African young women. The results showed that there was no significant difference in the prevalence of overweight and obesity between high SES and low SES women. Dietary patterns and physical activity had direct and indirect effects on BMI.
SOUTH AFRICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Amy E. Mendham, Lisa K. Micklesfield, Fredrik Karpe, Andre Pascal Kengne, Tinashe Chikowore, Clement N. Kufe, Maphoko Masemola, Nigel J. Crowther, Shane A. Norris, Tommy Olsson, Solve Elmstahl, Tove Fall, Lars Lind, Julia H. Goedecke
Summary: Using a targeted proteomics approach, this study aimed to identify and validate circulating proteins associated with impaired glucose metabolism and type 2 diabetes in a Black South African cohort. The results identified 34 proteins associated with type 2 diabetes, of which 11 were associated with measures of type 2 diabetes pathophysiology. This study highlights the similarity of biomarkers between different populations and emphasizes the need for validation in African cohorts.
Article
Endocrinology & Metabolism
Cynthia Mukwasi-Kahari, Andrea M. Rehman, Micheal O. Breasail, Ruramayi Rukuni, Tafadzwa Madanhire, Joseph Chipanga, Lynda Stranix-Chibanda, Lisa K. Micklesfield, Rashida A. Ferrand, Kate A. Ward, Celia L. Gregson
Summary: A cross-sectional study found that peripubertal children with chronic HIV infection had lower trabecular volumetric bone mineral density, cross-sectional area, and stress-strain index compared to children without HIV. These deficits were more pronounced in children in later puberty, and may contribute to a higher risk of fractures in the future.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Monica Muti, Lisa J. Ware, Lisa K. Micklesfield, Michele Ramsay, Godfred Agongo, Palwende R. Boua, Isaac Kisiangani, Ian Cook, Francesc Xavier Gomez-Olive, Nigel J. Crowther, Chodziwadziwa Kabudula, Shane A. Norris, Tinashe Chikowore
Summary: This study explores the association between self-reported physical activity and body mass index (BMI) in African adults. Results show that meeting physical activity guidelines is associated with lower BMI in both men and women. There are also site-specific differences in the associations between physical activity domains and BMI. In conclusion, physical activity may be an effective strategy to address obesity in Africa, but more research is needed to assess the impact of interventions tailored to gender and geographic location.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Review
Public, Environmental & Occupational Health
Lee Randall, Anna Brugulat-Panes, James Woodcock, Lisa Jayne Ware, Caitlin Pley, Safura Abdool Karim, Lisa Micklesfield, Gudani Mukoma, Lambed Tatah, Philip Mbulalina Dambisya, Sostina Spiwe Matina, Ian Hambleton, Gabriel Okello, Felix Assah, Megha Anil, Haowen Kwan, Alice Charity Awinja, Georgina Pujol-Busquets Guillen, Louise Foley
Summary: Active travel is crucial for public health in rapidly urbanizing countries, especially in Africa where urbanization and motorization are increasing. Public transport, particularly paratransit, plays a critical role in providing mobility options for poor peripheral residents, contributing to poverty reduction and reducing mode-shifting to private vehicles.
JOURNAL OF TRANSPORT & HEALTH
(2023)
Review
Green & Sustainable Science & Technology
Anna Brugulat-Panes, Lee Randall, Thiago Herick de Sa, Megha Anil, Haowen Kwan, Lambed Tatah, James Woodcock, Ian R. Hambleton, Ebele R. I. Mogo, Lisa Micklesfield, Caitlin Pley, Ishtar Govia, Sostina Spiwe Matina, Caroline Makokha, Philip M. Dambisya, Safura Abdool Karim, Georgina Pujol-Busquets, Kufre Okop, Camille M. Mba, Lisa J. Ware, Felix Assah, Betty Nembulu, Gudani Mukoma, Warren Covele Lucas, Nadia Bennett, Marshall K. Tulloch-Reid, Alice Charity Awinja, Tanmay Anand, Louise Foley
Summary: The Human Mobility Transition model explores shifts in mobility patterns and transport systems. The 'human urbanism' stage is characterized by high active travel, widespread public transport, limited private vehicle use, and equitable access to transportation. This study examines factors influencing travel behavior in Africa and the Caribbean and assesses the potential to achieve 'human urbanism' in these regions. A systematic review of ten databases and grey literature was conducted, resulting in the inclusion of 129 studies and 33 grey literature documents. The findings highlight the challenges of transport accessibility for marginalized groups and the need for coordinated urban planning and policies focusing on health, transport, and equity.
Article
Oncology
Oluwatosin A. Ayeni, Maureen Joffe, Witness Mapanga, Wenlong Carl Chen, Daniel S. O'Neil, Boitumelo Phakathi, Sarah Nietz, Ines Buccimazza, Sharon Cacala, Laura W. Stopforth, Judith S. Jacobson, Katherine D. Crew, Alfred I. Neugut, Duvern Ramiah, Paul Ruff, Herbert Cubasch, Tobias Chirwa, Valerie McCormack, Lisa K. Micklesfield, Shane A. Norris
Summary: This study investigated the impact of multimorbidity on overall survival among women with breast cancer in South Africa. The results showed that the presence of multiple chronic conditions is associated with lower overall survival in breast cancer patients, especially when accompanied by diseases such as diabetes, cardiovascular diseases, HIV, and obesity.
BREAST CANCER RESEARCH
(2023)
Article
Sport Sciences
Lisa K. Micklesfield, Kate Westgate, Antonia Smith, Clement N. Kufe, A. M. Y. E. Mendham, T. I. M. Lindsay, Katrien Wijndaele, Julia H. Goedecke, Soren Brage
Summary: This study described the physical activity behaviors of middle-age South African men and women and developed a method of combining hip and thigh accelerometery signals to quantify and describe these behaviors. The study found that men spent more time in moderate- to vigorous-intensity physical activity and sitting/lying, while women spent more time standing. Age, weight, and socioeconomic status were associated with physical activity behaviors.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Social Sciences, Interdisciplinary
Sarah Drew, Keabetswe Khutsoane, Nyasha Buwu, Celia L. Gregson, Lisa K. Micklesfield, Rashida A. Ferrand, Rachael Gooberman-Hill
Summary: Women in sub-Saharan Africa experience various impacts of menopause on their daily lives and have expressed a need for more information and support. This study collaborated with women in Zimbabwe and South Africa to develop culturally relevant resources about menopause, which have been refined, translated, and endorsed by local health authorities. The resources will be accessible through healthcare clinics, community groups, and churches.
SOCIAL SCIENCES-BASEL
(2022)