Recent developments in nucleobase cation symporter-1 (NCS1) family transport proteins from bacteria, archaea, fungi and plants

The Human Microbiota in Health and Disease

(2017) Baohong Wang et al.   Engineering

Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity

(2016) Pikyee Ma et al.   MICROBIOLOGY-SGM

Cryptic purine transporters inAspergillus nidulansreveal the role of specific residues in the evolution of specificity in the NCS1 family

(2016) Georgia Sioupouli et al.   MOLECULAR MICROBIOLOGY

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Heterologous complementation studies reveal the solute transport profiles of a two-member nucleobase cation symporter 1 (NCS1) family in Physcomitrella patens

(2016) Janet A. Minton et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

Functional characterization of NAT/NCS2 proteins of Aspergillus brasiliensis reveals a genuine xanthine–uric acid transporter and an intrinsically misfolded polypeptide

(2015) Emilia Krypotou et al.   FUNGAL GENETICS AND BIOLOGY

Origin, diversification and substrate specificity in the family of NCS1/FUR transporters

(2015) Emilia Krypotou et al.   MOLECULAR MICROBIOLOGY

The solute specificity profiles of nucleobase cation symporter 1 (NCS1) from Zea mays and Setaria viridis illustrate functional flexibility

(2015) Micah Rapp et al.   PROTOPLASMA

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1

(2014) K. J. Simmons et al.   EMBO JOURNAL

Structure-Function Relationship of a Plant NCS1 Member – Homology Modeling and Mutagenesis Identified Residues Critical for Substrate Specificity of PLUTO, a Nucleobase Transporter from Arabidopsis

(2014) Sandra Witz et al.   PLoS One

Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1

(2014) K. Kazmier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of the APC superfamily of secondary carriers

(2014) Ake Vastermark et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Common Folds and Transport Mechanisms of Secondary Active Transporters

(2013) Yigong Shi   Annual Review of Biophysics

Ligand- and drug-binding studies of membrane proteins revealed through circular dichroism spectroscopy

(2013) Giuliano Siligardi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Glucose transport families SLC5 and SLC50

(2013) Ernest M. Wright   MOLECULAR ASPECTS OF MEDICINE

The nucleobase cation symporter 1 of Chlamydomonas reinhardtii and that of the evolutionarily distant Arabidopsis thaliana display parallel function and establish a plant-specific solute transport profile

(2013) Jessica R. Schein et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Genetic and molecular characterization reveals a unique nucleobase cation symporter 1 in Arabidopsis

(2012) George S. Mourad et al.   FEBS LETTERS

Modeling, Substrate Docking, and Mutational Analysis Identify Residues Essential for the Function and Specificity of a Eukaryotic Purine-Cytosine NCS1 Transporter

(2012) Emilia Krypotou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amino Acid-Polyamine-Organocation Superfamily

(2012) Foon H. Wong et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Loss of Heterozygosity ofFCY2Leading to the Development of Flucytosine Resistance in Candida tropicalis

(2011) Yen-Ning Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The role of amino acid transporters in inherited and acquired diseases

(2011) Stefan Bröer et al.   BIOCHEMICAL JOURNAL

Simulations of the Alternating Access Mechanism of the Sodium Symporter Mhp1

(2011) Joshua L. Adelman et al.   BIOPHYSICAL JOURNAL

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

The ubiquitous Nucleobase-Ascorbate Transporter (NAT) family: Lessons from model microbial genetic systems

(2010) George Diallinas et al.   Channels

The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1

(2010) Simone Weyand et al.   JOURNAL OF SYNCHROTRON RADIATION

Structural basis of Na+-independent and cooperative substrate/product antiport in CaiT

(2010) Sabrina Schulze et al.   NATURE

Crystal structure of the carnitine transporter and insights into the antiport mechanism

(2010) Lin Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1

(2010) T. Shimamura et al.   SCIENCE

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

(2010) Stéphane Guindon et al.   SYSTEMATIC BIOLOGY

Synthesis of highly pure14C-labelledDL-allantoin and13C NMR analysis of labelling integrity

(2009) Simon G. Patching   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter inAspergillus nidulans

(2009) Zsuzsanna Hamari et al.   MOLECULAR MICROBIOLOGY

Molecular basis of transport and regulation in the Na+/betaine symporter BetP

(2009) Susanne Ressl et al.   NATURE

Crystallization of the hydantoin transporter Mhp1 fromMicrobacterium liquefaciens

(2008) Tatsuro Shimamura et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Saccharomyces cerevisiae YOR071CEncodes the High Affinity Nicotinamide Riboside Transporter Nrt1

(2008) Peter A. Belenky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleobase–ascorbate transporter (NAT) family: genomics, evolution, structure–function relationships and physiological role

(2008) Christos Gournas et al.   Molecular BioSystems

The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is downregulated by endocytosis

(2008) Anna Vlanti et al.   MOLECULAR MICROBIOLOGY

The Transporter Classification Database: recent advances

(2008) M. H. Saier et al.   NUCLEIC ACIDS RESEARCH

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

(2008) S. Weyand et al.   SCIENCE

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

(2008) S. Faham et al.   SCIENCE