Article
Developmental Biology
Silvan Spiri, Simon Berger, Louisa Mereu, Andrew DeMello, Alex Hajnal
Summary: During the development of Caenorhabditis elegans vulva, EGFR signaling in the uterine anchor cell plays a crucial role in aligning the uterus with the vulva.
Review
Cell Biology
Yuting Wang, Wei Wu, Jianke Gong
Summary: Micronutrients have a strong relationship with cell death and play a crucial role in maintaining human body health. Dysregulation of micronutrients can lead to various metabolic or chronic diseases such as obesity, cardiometabolic conditions, neurodegeneration, and cancer. The nematode Caenorhabditis elegans offers a valuable genetic model for studying the effects of micronutrients on metabolism, healthspan, and lifespan. Moreover, its characteristics like specific haem trafficking pathway and ease of studying different forms of cell death make it an excellent tool for understanding the underlying mechanisms. A comprehensive understanding of micronutrient metabolism and cell death not only helps in developing better treatments for micronutrient disorders but also provides insights into human health and aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sandeep Gopal, Aqilah Amran, Andre Elton, Leelee Ng, Roger Pocock
Summary: The study demonstrates that syndecan-1 in C. elegans regulates the expression of the GLP-1 receptor by promoting calcium-dependent binding, influencing germ cell mitosis. This reveals a potential communication pathway between somatic and germ cells to control germ cell fate.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Xuehua Ma, Zhiguang Zhao, Long Xiao, Weina Xu, Yahui Kou, Yanping Zhang, Gang Wu, Yangyang Wang, Zhuo Du
Summary: This study utilizes a protein expression atlas to uncover cell fate and regulatory factors in Caenorhabditis elegans embryonic development. The research reveals the spatiotemporal expression patterns of TFs and a series of TFs that specify developmental states. Furthermore, the atlas uncovers the unexpected role of unknown TFs in neurogenesis and muscle differentiation.
Article
Multidisciplinary Sciences
Hayao Ohno, Zhirong Bao
Summary: This study reveals that Caenorhabditis elegans undergoes alternative embryogenesis in response to maternal gut microbes, resulting in changes in cell divisions, morphology, and reproduction. The miR-35 microRNA family transmits intergenerational information to regulate embryonic development. These findings challenge the assumption of an invariant cell lineage in C. elegans and provide insights into how organisms adapt to environmental changes through epigenetic control.
Article
Developmental Biology
Kimberley D. Gauthier, Christian E. Rocheleau
Summary: The LIN-2/7/10 complex in Caenorhabditis elegans plays a crucial role in regulating the localization and signaling of EGFR, with LIN-7 colocalizing with EGFR at the basolateral membrane and the complex itself forming on the Golgi to target EGFR trafficking to the basolateral membrane.
Article
Genetics & Heredity
Evan M. Soukup, Jill C. Bettinger, Laura D. Mathies
Summary: This study identifies genes that regulate the fate of somatic gonadal precursors and the generation of descendant cells, demonstrating that these processes are genetically separable.
G3-GENES GENOMES GENETICS
(2022)
Review
Cell Biology
Stephen F. Goodwin, Oliver Hobert
Summary: Male and female brains exhibit anatomical and functional differences, which have been well-studied in animal species including humans. Recent advances have revealed insights into how the worm and fly brains develop sexually dimorphic features, with each system offering unique advantages for studying sex-specific behaviors.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 37
(2021)
Article
Developmental Biology
Sabih Rashid, Christopher Wong, Richard Roy
Summary: Developmental plasticity refers to an organism's ability to adapt to environmental stressors, including nutritional stress. In Caenorhabditis elegans, inadequate nutrition can lead to various diapause stages, with AMP-activated protein kinase (AMPK) playing a crucial role in regulating metabolism and germline development. AMPK orchestrates a network of signaling pathways to preserve reproductive fitness during challenging periods.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sneha L. Koneru, Mark Hintze, Dimitris Katsanos, Michalis Barkoulas
Summary: This study addresses how genetic background modifies mutation expression, focusing on seam cell development in Caenorhabditis elegans isolates. It is demonstrated that a single amino acid deletion in a conserved heat shock protein HSP-110 in the CB4856 isolate can modify Wnt signaling and seam cell development, highlighting natural variation can shape phenotype expressivity.
NATURE COMMUNICATIONS
(2021)
Article
Developmental Biology
Hang-Shiang Jiang, Piya Ghose, Hsiao-Fen Han, Yun-Zhe Wu, Ya-Yin Tsai, Huang-Chin Lin, Wei-Chin Tseng, Jui-Ching Wu, Shai Shaham, Yi-Chun Wu
Summary: The study reveals a mechanism controlling tail-spike cell death onset in Caenorhabditis elegans, indicating the role of BLMP-1 in regulating embryonic tail-spike cell death initiation. BLMP-1 is expressed in tail-spike cells and promotes cell survival by inhibiting ced-9 transcription before cell-death onset.
Article
Biochemistry & Molecular Biology
Seiryu Ishikawa, Chiharu Iida, Yuka Takezawa, Kyoko Chiba, Eriko Kage-Nakadai
Summary: This study investigates the mechanisms behind the tolerance of bitter compounds in Caenorhabditis elegans that is dependent on previous experience. The nematodes exhibited aversion to nicotinamide, MgCl2, isoleucine, and arginine in a G alpha-dependent manner. Worms also showed decreased avoidance of MgCl2 after being pre-exposed to it at the larval stages. AIY interneurons have been suggested to play a role in experience-dependent behavioral plasticity.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Sui Lo, Marianne Roca, Mohannad Dardiry, Marisa Mackie, Gabi Eberhardt, Hanh Witte, Ray Hong, Ralf J. Sommer, James W. Lightfoot
Summary: TGF-beta signaling is essential in nematodes, and it exhibits gene frequency variability and functional divergence, contributing to the generation of novel functions through genetic mutations.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Biology
Marcello Germoglio, Adele Adamo, Guido Incerti, Fabrizio Carteni, Silvia Gigliotti, Aurora Storlazzi, Stefano Mazzoleni
Summary: This study investigates the effects of dietary delivered self-DNA in the nematode Caenorhabditis elegans. The exposure to self-DNA integrated into their bacterial diet leads to adverse effects on egg deposition, embryo death, and larval development. The findings raise questions on the molecular mechanisms involved in response to extracellular self-DNA and suggest potential applications in the biocontrol of parasitic nematodes.
Article
Genetics & Heredity
Aleksandra Fergin, Gabriel P. Boesch, Nadja Greter, Simon P. Berger, Alex Hajnal
Summary: This study investigates the effects of SUMO protein modification on organ development using Caenorhabditis elegans. The results show that the SUMO pathway acts in multiple tissues to regulate different cellular functions and the SUMO modification of the transcription factor LIN-1 is necessary for proper organ morphogenesis.
Article
Developmental Biology
Stephanie Grimbert, Kyria Tietze, Michalis Barkoulas, Paul W. Sternberg, Marie-Anne Felix, Christian Braendle
DEVELOPMENTAL BIOLOGY
(2016)
Article
Ecology
Anne Vielle, Nicolas Callemeyn-Torre, Clotilde Gimond, Nausicaa Poullet, Jeremy C. Gray, Asher D. Cutter, Christian Braendle
Article
Ecology
Nausicaa Poullet, Anne Vielle, Clotilde Gimond, Sara Carvalho, Henrique Teotonio, Christian Braendle
Article
Genetics & Heredity
Daniel E. Cook, Stefan Zdraljevic, Robyn E. Tanny, Beomseok Seo, David D. Riccardi, Luke M. Noble, Matthew V. Rockman, Mark J. Alkema, Christian Braendle, Jan E. Kammenga, John Wang, Leonid Kruglyak, Marie-Anne Felix, Junho Lee, Erik C. Andersen
Article
Genetics & Heredity
Andreas H. Ludewig, Clotilde Gimond, Joshua C. Judkins, Staci Thornton, Dania C. Pulido, Robert J. Micikas, Frank Doering, Adam Antebi, Christian Braendle, Frank C. Schroeder
Article
Ecology
Celine Ferrari, Romain Salle, Nicolas Callemeyn-Torre, Richard Jovelin, Asher D. Cutter, Christian Braendle
Article
Biochemistry & Molecular Biology
Lise Frezal, Emilie Demoinet, Christian Braendle, Eric Miska, Marie-Anne Felix
Article
Genetics & Heredity
Stephanie Grimbert, Amhed Missael Vargas Velazquez, Christian Braendle
G3-GENES GENOMES GENETICS
(2018)
Article
Genetics & Heredity
Clotilde Gimond, Anne Vielle, Nuno Silva-Soares, Stefan Zdraljevic, Patrick T. McGrath, Erik C. Andersen, Christian Braendle
Article
Ecology
Daehan Lee, Stefan Zdraljevic, Daniel E. Cook, Lise Frezal, Jung-Chen Hsu, Mark G. Sterken, Joost A. G. Riksens, John Wang, Jan E. Kammenga, Christian Braendle, Marie-Anne Felix, Frank C. Schroeder, Erik C. Andersen
NATURE ECOLOGY & EVOLUTION
(2019)
Article
Biochemistry & Molecular Biology
Benedicte Billard, Paul Vigne, Christian Braendle
Article
Biochemistry & Molecular Biology
Eyal Ben-David, Pinelopi Pliota, Sonya A. Widen, Alevtina Koreshova, Tzitziki Lemus-Vergara, Philipp Verpukhovskiy, Sridhar Mandali, Christian Braendle, Alejandro Burga, Leonid Kruglyak
Summary: The study reveals the presence of maternal-effect TAs in C. tropicalis and C. briggsae, causing significant intraspecific incompatibility. The identification of new TAs genes and their role in larval development suggests TAs are widespread in Caenorhabditis species, and their spreading in populations is affected by balancing selection.
Article
Biology
Luke M. Noble, John Yuen, Lewis Stevens, Nicolas Moya, Riaad Persaud, Marc Moscatelli, Jacqueline L. Jackson, Gaotian Zhang, Rojin Chitrakar, L. Ryan Baugh, Christian Braendle, Erik C. Andersen, Hannah S. Seidel, Matthew Rockman
Summary: Mating systems have significant impacts on genetic diversity and compatibility. The self-fertilizing Caenorhabditis tropicalis has the lowest genetic diversity and is most affected by outbreeding depression. Laboratory studies show that outbreeding depression in C. tropicalis is mainly caused by Medea-like elements, and frequent selfing may be a strategy to avoid these negative effects.
Article
Multidisciplinary Sciences
Paul Vigne, Clotilde Gimond, Celine Ferraris, Anne Vielle, Johan Hallin, Ania Pino-Querido, Sonia El Mouridi, Laure Mignerot, Christian Frokjaer-Jensens, Thomas Boulin, Henrique Teotonio, Christian Braendle
Summary: The study reveals that a single amino acid change in a potassium channel subunit can lead to matricidal hatching in nematodes by reducing the sensitivity to environmental stimuli triggering egg-laying, and this trait can be maintained under fluctuating resource availability.
Article
Ecology
Daehan Lee, Stefan Zdraljevic, Lewis Stevens, Ye Wang, Robyn E. Tanny, Timothy A. Crombie, Daniel E. Cook, Amy K. Webster, Rojin Chirakar, L. Ryan Baugh, Mark G. Sterken, Christian Braendle, Marie-Anne Felix, Matthew Rockman, Erik C. Andersen
Summary: The transition from outcrossing to selfing in different species has been found to decrease genetic diversity, which in turn reduces adaptive potential. However, in the Caenorhabditis genus, selfing species maintain genetic diversity by concentrating variation in hyper-divergent regions rich in environmental response genes, enabling them to adapt to diverse environments.
NATURE ECOLOGY & EVOLUTION
(2021)