Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

Physiological Modeling to Understand the Impact of Enzymes and Transporters on Drug and Metabolite Data and Bioavailability Estimates

(2010) Huadong Sun et al.   PHARMACEUTICAL RESEARCH

Physiologically Based Modelling and Prediction of Drug Interactions

(2009) Frédéric Y. Bois   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Proposals for model-based paediatric medicinal development within the current European Union regulatory framework

(2009) Efthymios Manolis et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Semiphysiologically Based Pharmacokinetic Models for the Inhibition of Midazolam Clearance by Diltiazem and Its Major Metabolite

(2009) X. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Physiologically based pharmacokinetics (PBPK)

(2009) Pascal Espié et al.   DRUG METABOLISM REVIEWS

Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

(2009) Karen Rowland Yeo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetic predictions in children by using the physiologically based pharmacokinetic modelling

(2008) F. Bouzom et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO