Article
Polymer Science
Supamas Napavichayanun, Prompong Pienpinijtham, Narendra Reddy, Pornanong Aramwit
Summary: This study aimed to develop natural scaffolds using natural agents and simple and green crosslinking methods, and successfully improved the performance of the scaffolds by adding plasticizers. The scaffolds exhibited good biological properties and may have potential applications in controlled drug release and wound healing.
Article
Biophysics
Yanwei Li, Tangfeng Wu, Guozheng Zhang, Ai Fang, Yurong Li, Susu Wang, Hui Yan, Peisheng Liang, Jialin Lian, Yeshun Zhang
Summary: In this study, a novel bioactive dressing based on native nondestructive sericin was developed. The dressing was directly secreted by silkworms through regulating their spinning behaviors. It possessed natural structures and bioactivities, as well as a porous fibrous network structure with high air permeability. Furthermore, the dressing showed pH-responsive degradability, softness, super absorbency, and high mechanical strength. It also supported cell viability, proliferation, and migration, and significantly accelerated the healing process in a mouse full-thickness skin wound model. These findings suggest that the sericin wound dressing has promising application and commercial value in wound repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
T. K. Vasudha, Anand Kumar Patel, Vignesh Muthuvijayan
Summary: This study developed an antibacterial and biocompatible wound dressing by modifying the natural polysaccharide Isabgol. The modified material showed antimicrobial activity and had suitable physical properties. The porous structure of the scaffold allowed gas and nutrient exchange, and the material could absorb wound exudates and maintain a moist environment. In vitro studies confirmed the compatibility of the scaffolds with cells and blood.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Hassaninejad Farahani, Fatemeh Moraffah, Nasrin Samadi, Mohammad Sharifzadeh, Hamidreza Motasadizadeh, Alireza Vatanara
Summary: Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers and freeze-dried, resulting in a stable composition. The effects of polymer concentrations and prebiotics on probiotic viability and swelling behavior were examined using a D-optimal design. The optimized formulation showed a viability percentage of over 82% and should be stored refrigerated. In vivo testing demonstrated improved wound healing indicators and the ability to modify wound inflammatory responses, making it comparable to silver sulfadiazine ointment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biophysics
Zhongfei Gao, Qinbing Qi, Rongkai Li, Chengbo Li, Xianrui Xie, Guige Hou
Summary: A nanofiber/sponge bilayered composite membrane (QCP) containing quaternized silicone and quaternized chitosan was developed as a potential wound dressing, with feasible permeability, suitable mechanical properties, and the ability to enhance wound healing.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Xiaoying Lin, Yue Feng, Yunqing He, Shan Ding, Mingxian Liu
Summary: In this study, a silicone-coated sponge was prepared by directional freeze-drying method for rapid and effective hemostasis. The sponge with aligned channel structure showed high antibacterial properties and hemocompatibility, and it rapidly clotted and reduced blood loss in rat experiments. This work developed a high-performance hemostatic dressing with promising application in wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Wencheng Liang, Mingli Jiang, Junyong Zhang, Xiaoming Dou, Yan Zhou, Yun Jiang, Li Zhao, Meidong Lang
Summary: In this study, novel antibacterial composite scaffolds were prepared with improved water absorption rate, water retention rate, and mechanical strength compared to traditional scaffolds. The addition of hyaluronic acid enhanced the biocompatibility of the scaffolds, and the positive charge in the scaffolds contributed to their antibacterial activity. The scaffolds showed potential for wound healing and could be used as wound dressings.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Singaravelu Sivakumar, Ragothaman Murali, Deepika Arathanaikotti, Arun Gopinath, Chinnaiyan Senthilkumar, Satheshkumar Kesavan, Balaraman Madhan
Summary: The prepared biomimetic fibrin/chitosan/keratin hybrid scaffolds with ferulic acid loaded silica microspheres demonstrate good thermal properties, porosity, compression strength, and water uptake capacity, as well as effective antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Yuan Cheng, M. R. Morovvati, Menghui Huang, M. Shahali, S. Saber-Samandari, S. Niazi Angili, Mazyar Ghadiri Nejad, M. Shakibaie, Davood Toghraie
Summary: In this study, pure chitosan and gelatin solutions were blended with Fluorohydroxyapatite (FHA) at various ratios to produce porous scaffolds, which were analyzed using XRD and SEM. The specimen containing 70% chitosan and 30% gelatin showed the best morphological uniformity and in-vitro biocompatibility properties. Additionally, the mechanical properties were enhanced with the addition of 30 wt% FHA nanoparticles.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Biochemistry & Molecular Biology
Mahla Lashkari, Mahya Rahmani, Yaser Yousefpoor, Meysam Ahmadi-Zeidabadi, Reza Faridi-Majidi, Zahra Ameri, Moein Salary, Shahrzad Azizi, Arman Shahabi, Amid Rahi, Mohamad Javad Mirzaei-Parsa
Summary: In this study, a bilayer scaffold composed of hydrogel and nanofibers was fabricated to improve the regeneration of injured skin. The results showed that re-epithelialization, angiogenesis, and collagen remodeling were enhanced in ADSCs-seeded bilayer scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yang Yang, Yanyan Zhang, Yuanping Min, Jinghua Chen
Summary: This study presents a feasible strategy to construct a rapid hemostatic sponge for deep and non-compressible perforating wounds. The sponge, based on methacrylated collagen and hyaluronate, demonstrated excellent mechanical strength and superior blood clotting capacity in vitro and in a rat-liver injury model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Elisa Capuana, Francesco Lopresti, Francesco Carfi Pavia, Valerio Brucato, Vincenzo La Carrubba
Summary: The review paper discusses various scaffold fabrication methods starting from polymer solutions that provide highly porous structures, such as freeze-drying, thermally or diffusion induced phase separation, and electrospinning. The combination of these techniques offers the advantage of mimicking the unique architecture of tissues and organs that are intrinsically difficult to design.
Article
Polymer Science
Xuefei Chen, Qianqian Zhang, Yi Wang, Jie Meng, Meiqin Wu, Huaizhong Xu, Lei Du, Xiaohua Yang
Summary: In this study, tannic acid was successfully loaded into poly(caprolactone) fibers via electrospinning, resulting in uniform and continuous nanofibers. The addition of tannic acid improved the mechanical properties of the scaffolds and enhanced their hydrophilicity and water absorption capacity, which contribute to wound healing acceleration.
Article
Chemistry, Medicinal
Juan Davagnino, John P. Gabrielson
Summary: This article presents a simple approach to develop a robust lyophilized formulation in the presence of salt and at low protein concentration, combined with a commercially viable lyophilization cycle. It can be used as a starting point for the development of protein-based pharmaceutical products and allows the production of placebo vials with no visual differences compared to the active product.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Zehra Gun Gok, Mustafa Yigitoglu, Ibrahim Vargel, Yasar Sahin, Mehmet Eray Alcigir
Summary: In this study, silver nanoparticles coated with sericin were adsorbed on PET-g-HEMA nanofibers to create a wound dressing material with antimicrobial effects on gram positive and gram negative bacteria. The modified nanofibers showed high cell viability rates and were more effective in wound healing compared to the control group during in-vivo studies on rats, with a healing rate close to a commercially used cover material.
MATERIALS CHEMISTRY AND PHYSICS
(2021)