Article
Materials Science, Biomaterials
Xiongcheng Xu, Long Xiao, Yanmei Xu, Jin Zhuo, Xue Yang, Li Li, Nianqi Xiao, Jing Tao, Quan Zhong, Yanfen Li, Yuling Chen, Zhibin Du, Kai Luo
Summary: The study developed a PCL/LAP scaffold with excellent bioactivity using 3D printing technology, promoting osteogenic differentiation and angiogenesis of bone marrow mesenchymal stem cells, resulting in significant enhancement of vascularized bone formation in a calvarial defect model.
REGENERATIVE BIOMATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Hairui Suo, Yu Chen, Jiali Liu, Ling Wang, Mingen Xu
Summary: A novel biphasic scaffold was designed and fabricated using HAp and PCL through a multi-nozzle 3D printing technique, showing mechanical properties between pure HAp and PCL scaffolds. Finite element simulation demonstrated a biomimetic strengthened structure of the biphasic scaffold under compression, suitable for osteochondral tissue engineering applications.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Biology
Yingnan Geng, Huichuan Duan, Liang Xu, Nevin Witman, Bingqian Yan, Zheyuan Yu, Huijing Wang, Yao Tan, Liqin Lin, Dong Li, Shanshan Bai, Regina Fritsche-Danielson, Jie Yuan, Kenneth Chien, Min Wei, Wei Fu
Summary: The study explores the potential of using chemically modified mRNAs encoding hBMP-2 and VEGF-A to therapeutically heal bone injuries. By inoculating bone marrow stem cells treated with these modRNAs in a collagen scaffold, superior healing properties were observed, showcasing the synergistic effects of hBMP-2 and VEGF-A in driving osteogenic and angiogenic pathways for potential clinical applications in bone injury treatment.
COMMUNICATIONS BIOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Inigo Perez-Estenaga, Merari Tumin Chevalier, Estefania Pena, Gloria Abizanda, Amir M. Alsharabasy, Eduardo Larequi, Myriam Cilla, Marta M. Perez, Jon Gurtubay, Manuel Garcia-Yebenes Castro, Felipe Prosper, Abhay Pandit, Beatriz Pelacho
Summary: Ischemic heart disease is a major cause of death worldwide. A collagen hydrogel loaded with pro-angiogenic SDF1 was combined with a compact collagen membrane to create a bilayer collagen-on-collagen scaffold (bCS), capable of efficiently delivering therapeutic growth factors after myocardial infarction (MI). In vitro and in vivo studies demonstrated that the bCS had suitable physicochemical properties, leading to sustained release of SDF1, integration into the heart tissue, anti-inflammatory and pro-angiogenic macrophage presence, revascularization, and improved cardiac function. This multimodal scaffold can serve as a promising matrix for drug delivery and functional recovery after MI.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Itay Zusmanovitch, Thabet Asbi, Oshrat Regev, Hadar Zigdon Giladi, Havazelet Bianco-Peled
Summary: The study aimed to create an improved scaffold for bone tissue engineering that meets the requirements of cells, cytokines, and mechanical demands. By using an integrative approach and considering crucial design criteria, such as high porosity, a wide range of pore sizes, a hydrophilic and rough surface, and biofunctionalization, polycaprolactone (PCL) was chosen as the scaffold material and its bioactivity was improved using various methods. The thoroughly characterized scaffolds demonstrated enhanced cell adhesion and proliferation, as well as high hydrophilicity, high porosity with interconnected pores, stiffness, and improved bioactivity compared to other studied scaffolds, making them a promising platform for bone engineering.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Quanying Liu, Manyu Chen, Peiyang Gu, Lei Tong, Peilei Wang, Jiayi Zhu, Yang Xu, Gonggong Lu, En Luo, Jie Liang, Yujiang Fan, Xingdong Zhang, Yong Sun
Summary: Integrating a biomimetic extracellular matrix into 3D printing scaffolds improves the microenvironment for bone substitute design. A soft-hard bone implant (BM-g-DPCL) was constructed, consisting of a bioactive matrix integrated chemically on a polydopamine-coated porous gradient scaffold. The implant promoted bone tissue integration and induced bone matrix deposition.
Article
Biophysics
Bo Wang, Guanghua Lu, Kaihang Song, Aopan Chen, Hu Xing, Jiezhou Wu, Qi Sun, Gen Li, Ming Cai
Summary: In this study, dual bioactive agent-loaded electrospinning nanofibers were successfully prepared for the treatment of infectious wounds. The addition of zinc oxide nanoparticles and vascular endothelial growth factors to the fibers resulted in membranes with suitable physicochemical properties and promising biological activity, as demonstrated through in vitro and in vivo experiments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Souvik Ghosh, Partha Roy, Debrupa Lahiri
Summary: This study modulates the arrangement of multi-walled carbon nanotube (MWCNT) reinforcement in a biodegradable scaffold by applying an external electric field. The structure of the reinforcement affects the morphology of differentiating neural cells, and when combined with electrical stimulation, it shows potential for directional nerve regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Carly Boye, Kyle Christensen, Kamal Asadipour, Scott DeClemente, Michael Francis, Anna Bulysheva
Summary: This study optimized gene electrotransfer and bioprinting techniques to accelerate tendon healing, showing that the combination of collagen scaffolds and angiogenic GET therapy can improve angiogenesis and biocompatibility of implants, potentially enhancing graft biocompatibility in tendon repair.
BIOELECTROCHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Hedong Yu, Lingyun Xia, Xieyuan Leng, Yongji Chen, Li Zhang, Xiaobing Ni, Jie Luo, Weidong Leng
Summary: This study shows that grafting EPCs and BMSCs into a HA/CS/PCL composite scaffold can effectively repair calvarial defects by regulating the expression of endogenous BMP-2, VEGF, and PDGF.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Punam Kumari, Vinu Vijayan, Sreelekshmi Sreekumar, Rachita Lakra, Uma Tiruchirapalli Sivagnanam, Manikantan Syamala Kiran
Summary: The current study focuses on developing polysaccharide mucilage collagen aerogels for tissue engineering and bio-integrative applications. The analysis of the fabricated aerogels showed improved structural topography, thermal stability, wettability, water retention capacity, and hemo and cytocompatibility due to the incorporation of flax seed mucilage. The reinforced aerogels also exhibited pro-angiogenic potential and low ROS generation, making them a promising alternative to traditional collagen-based biomaterials for soft tissue engineering applications.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Luthfia Anindya Yuwono, Siswanto, Mona Sari, Yusril Yusuf, Tri Suciati, Yessie Widya Sari, Che Azurahanim Che Abdullah, Aminatun
Summary: In this study, a bone scaffold composed of hydroxyapatite (HA)-polycaprolactone (PCL)-collagen was fabricated to promote bone remodeling and healing. The HA/PCL/collagen 50:25:25 (F3) sample exhibited the best characteristics as a bone scaffold candidate.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Chemistry, Physical
Xiao Li, Ning He, Xiaojing Li, Xu Wang, Lei Zhan, Jialin Song, Wei-En Yuan, Yuanming Ouyang
Summary: A conductive GDY nanomaterial-loaded PCL scaffold was prepared and evaluated for its biocompatibility and effectiveness in peripheral nerve regeneration. The GDY/PCL scaffold significantly improved the proliferation, adhesion, and glial expression of Schwann cells, as well as promoted myelination and axonal growth in a rat sciatic nerve defect model. Additionally, upregulation of vascular factor expression suggested a potential role in angiogenesis for nerve repair.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Biomedical
Chase S. Linsley, Max Zhu, Viola Y. Quach, Benjamin M. Wu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Dentistry, Oral Surgery & Medicine
Kumar C. Shah, Denny Chao, Benjamin M. Wu, Ole T. Jensen
ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA
(2019)
Article
Dentistry, Oral Surgery & Medicine
Kumar C. Shah, Chase S. Linsley, Benjamin M. Wu
JOURNAL OF PROSTHETIC DENTISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Chase S. Linsley, Pierre Chesnot, Kumar C. Shah, Benjamin M. Wu, James Park, Young R. Seo
JOURNAL OF PROSTHETIC DENTISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Adam S. C. Siu, James K. F. Chow, Benny H. C. Au Yeung, Chase S. Linsley, Benjamin M. Wu
JOURNAL OF PROSTHETIC DENTISTRY
(2020)
Article
Multidisciplinary Sciences
Zhong-Kai Cui, Soyon Kim, Jessalyn J. Baljon, Benjamin M. Wu, Tara Aghaloo, Min Lee
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Xin Chen, Yulong Zhang, Benjamin Wu, Gaurav Sant
Article
Materials Science, Multidisciplinary
Zeyi Guan, Chase S. Linsley, Injoo Hwang, Gongcheng Yao, Benjamin M. Wu, Xiaochun Li
Article
Dentistry, Oral Surgery & Medicine
Dongyu Fang, Fangming Li, Yulong Zhang, Yuxing Bai, Benjamin M. Wu
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2020)
Article
Materials Science, Multidisciplinary
Zeyi Guan, Chase S. Linsley, Shuaihang Pan, Christina Debenedetto, Jingke Liu, Benjamin M. Wu, Xiaochun Li
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2020)
Article
Engineering, Biomedical
Jiabing Fan, Chung-Sung Lee, Soyon Kim, Xiao Zhang, Joan Pi-Anfruns, Mian Guo, Chen Chen, Matthew Rahnama, Jiong Li, Benjamin M. Wu, Tara L. Aghaloo, Min Lee
Summary: The study found that Trb3 promotes osteoblastic commitment of MSCs while inhibiting adipocyte differentiation, regulating cell-fate choice through BMP/Smad and Wnt/beta-catenin signals. Local delivery of Trb3 using a GelCA-PLGA scaffold stimulated bone regeneration and inhibited fat-filled cyst formation, demonstrating a potential therapeutic strategy for improved skeletal regeneration and treatment of bone-loss disease.
Article
Materials Science, Multidisciplinary
Jasmine Li, Jingke Liu, Zeyi Guan, Gongcheng Yao, Chase Linsley, Benjamin M. Wu, Jenn-Ming Yang
Correction
Multidisciplinary Sciences
Aaron W. James, Jia Shen, Xinli Zhang, Greg Asatrian, Raghav Goyal, Jin H. Kwak, Lin Jiang, Benjamin Bengs, Cymbeline T. Culiat, A. Simon Turner, Howard B. Seim, Benjamin M. Wu, Karen Lyons, John S. Adams, Kang Ting, Chia Soo
Summary: A correction to the paper has been published.
NATURE COMMUNICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Denny Chao, Russell Crockett, Benjamin Wu, Kumar Shah
JOURNAL OF PROSTHETIC DENTISTRY
(2020)
Article
Biochemical Research Methods
Kuan-Wen Tung, Pei-Shan Chung, Cong Wu, Tianxing Man, Sidhant Tiwari, Ben Wu, Yuan-Fang Chou, Fu-ling Yang, Pei-Yu Chiou