Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Chemistry, Multidisciplinary
Prerak Gupta, Biman B. Mandal
Summary: Vascular tissue engineering has made significant progress in recent years, with new technological advancements fostering the development of next-generation tissue-engineered vascular grafts. Traditional therapeutic methods involve bypassing damaged vessels with synthetic counterparts, while contemporary perspectives focus on biodegradable conduits with inherent remodeling capabilities.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
He Wang, Mengmeng Xing, Weiliang Deng, Meng Qian, Fei Wang, Kai Wang, Adam C. Midgley, Qiang Zhao
Summary: By immobilizing stem cell antigen-1 (Sca-1) antibody, the vascular graft can promote the role of vascular stem/progenitor cells (SPCs) in vascular regeneration and induce rapid vascular regeneration from local tissues and bone marrow.
BIOACTIVE MATERIALS
(2022)
Article
Medicine, Research & Experimental
Zhichao Ni, Lingxia Lyu, Hui Gong, Luping Du, Zuoshi Wen, Hua Jiang, Hao Yang, Yanhua Hu, Bohuan Zhang, Qingbo Xu, Xiaogang Guo, Ting Chen
Summary: This study aimed to investigate the cellular sources that reshape vein grafts. By analyzing transcriptomics data and constructing inducible lineage-tracing mouse models, the researchers demonstrated that Sca-1(+) cells played important roles in vein grafts and could serve as progenitors for multilineage commitment. They also found that recipient Sca-1(+) cells dominated reendothelialization and the formation of adventitial microvessels, while bone-marrow-derived Sca-1(+) cells differentiated into inflammatory cells in vein grafts. Furthermore, non-bone-marrow-derived circulatory Sca-1(+) cells were vital for the formation of adventitial microvessels, while Sca-1(+) cells derived from local carotid arteries were the source of endothelium restoration.
Article
Multidisciplinary Sciences
Juan Yan, Haoran Xiao, Xin Zhou, Yanzhao Li, Shanlan Zhao, Xingli Zhao, Yong Liu, Min Liu, Fangchao Xue, Qiao Zhang, Wenyan Zhao, Lang Li, Yang Su, Wen Zeng
Summary: Calcification of autologous pathological vessels and tissue engineering blood vessels is a significant clinical challenge. Gli1(+) cells play a role in vascular calcification, and an anticalcification approach utilizing exosomes derived from mesenchymal stem cells delivering lncRNA-ANCR was developed. This approach effectively targeted Gli1(+) cells, inhibited their differentiation into osteoblast-like cells, and prevented vascular calcification.
Review
Biotechnology & Applied Microbiology
David Duran-Rey, Veronica Crisostomo, Juan A. Sanchez-Margallo, Francisco M. Sanchez-Margallo
Summary: Pathologies related to the cardiovascular system are leading causes of death worldwide, with tissue-engineered vascular grafts (TEVGs) showing promise for clinical treatments. The use of TEVG in human patients is restricted due to vascular stenosis, thrombi, and poor graft patency. Research is focused on developing safe devices for TEVGs and small-diameter grafts show a tendency for thrombosis and non-patency.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Bing Dong, Yumin Qiu, Zhefu Liu, Jinsheng Huang, Zhichao Wang, Qiang Tu, Zhe Zhou, Jiang He, Yong Wang, Xiaolin Liu, Jianning Zhang, Xintao Shuai, Jun Tao, Wenhao Xia
Summary: By studying EPC-EXO from patients with coronary heart disease and healthy volunteers, it was found that C-EPC-EXO was less effective than H-EPC-EXO in improving angiogenesis. Manipulating the bioactivities of C-EPC-EXO through miR-199a-3p inhibition and cRGD decoration can significantly promote ECs-mediated angiogenesis for treating ischemic vascular diseases.
Review
Cell & Tissue Engineering
Amankeldi A. Salybekov, Mehdi Hassanpour, Shuzo Kobayashi, Takayuki Asahara
Summary: Chronic diseases and associated risk factors can negatively affect the function of regenerative cells and the regenerative microenvironment. The vasculogenic conditioning culture (VCC) method has been developed to enhance the regenerative microenvironment and generate regeneration-associated cells (RACs), which consist of vasculogenic endothelial progenitor cells (EPCs) and anti-inflammatory/anti-immunity cells. Both preclinical and clinical studies have shown that RAC transplantation is a safe and effective approach for promoting tissue recovery in ischemic conditions. This comprehensive review highlights the universal features of RACs and the latest advancements in their translation to clinical applications.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Pablo C. Caracciolo, Patricia Diaz-Rodriguez, Ines Ardao, David Moreira, Florencia Montini-Ballarin, Gustavo A. Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study developed bioresorbable small-diameter vascular grafts functionalized with heparin to promote endothelial cell growth and inhibit smooth muscle cells over-proliferation. The tensile properties of the heparin-functionalized vascular grafts resembled those of saphenous veins, indicating potential clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Diego Herrero, Guillermo Albericio, Marina Higuera, Maria Herranz-Lopez, Miguel A. Garcia-Brenes, Alejandra Cordero, Enrique Roche, Pilar Sepulveda, Carmen Mora, Antonio Bernad
Summary: Research on the interaction of adult cardiac progenitor cells with other cardiac cell populations can define the vascular cardiac stem cell niche, which is associated with low oxidative stress domains in vasculature, and manipulating this niche may offer new hope in the cardiac regeneration field.
Article
Peripheral Vascular Disease
Xenia Kraus, Edda van de Flierdt, Jannis Renzelmann, Stefanie Thoms, Martin Witt, Thomas Scheper, Cornelia Blume
Summary: This study compares the phenotype of PB-derived ECFC with arterial and venous model cells, and suggests that PB-derived ECFC have an arterial phenotype and may be a promising cell source for pre-endothelialization of arterial TEVGs.
MICROVASCULAR RESEARCH
(2022)
Article
Polymer Science
Xingyu Yuan, Wen Li, Bin Yao, Zhao Li, Deling Kong, Sha Huang, Meifeng Zhu
Summary: Synthetic vascular grafts made from the polymer PLCL show great promise for directing tissue regeneration. A tri-layered structure composed of a smooth inner layer, circumferentially aligned fibrous middle layer, and randomly distributed fibrous outer layer was successfully prepared using ink printing, wet spinning, and electrospinning techniques. These grafts exhibited kink resistance and mechanical properties equivalent to clinical standard conduits, and showed visible guiding effects on specific vascular cells.
Article
Pharmacology & Pharmacy
Haiyan Yang, Cancan He, Yang Bi, Xu Zhu, Dan Deng, Tingting Ran, Xiaojuan Ji
Summary: This study found that VEGF and SDF-1 alpha synergistically enhance the migration, differentiation, and proliferation capabilities of EPCs, but not VSMCs. This finding provides a promising strategy for the prevention of vascular stenosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Alice Costa, Gianandrea Pasquinelli
Summary: Extensive evidence indicates that air pollution exposure is associated with an increased risk of cardiovascular disease development. Fine particulate matter, one of the main components of urban pollution, exerts adverse effects on the cardiovascular system through unknown mechanisms. This review provides an overview of the potential mechanisms by which air pollution hinders vascular repair by altering the functionality of stem cells and progenitor cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Health Care Sciences & Services
Bill J. Wright, Keri B. Vartanian, Hsin-Fang Li, Natalie Royal, Jennifer K. Matson
Article
Endocrinology & Metabolism
Amy E. B. Packard, Philberta Y. Leung, Keri B. Vartanian, Susan L. Stevens, Frances R. Bahjat, Mary P. Stenzel-Poore
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2012)
Article
Endocrinology & Metabolism
Keri B. Vartanian, Hugh D. Mitchell, Susan L. Stevens, Valerie K. Conrad, Jason E. McDermott, Mary P. Stenzel-Poore
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2015)
Article
Biochemistry & Molecular Biology
Raffaella Gesuete, Amy E. B. Packard, Keri B. Vartanian, Valerie K. Conrad, Susan L. Stevens, Frances R. Bahjat, Tao Yang, Mary P. Stenzel-Poore
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Multidisciplinary Sciences
Jason E. McDermott, Keri B. Vartanian, Hugh Mitchell, Susan L. Stevens, Antonio Sanfilippo, Mary P. Stenzel-Poore
Review
Clinical Neurology
Susan L. Stevens, Keri B. Vartanian, Mary P. Stenzel-Poore
Article
Rheumatology
Brandon D. Markway, Holly Cho, Brian Johnstone
ARTHRITIS RESEARCH & THERAPY
(2013)
Article
Cardiac & Cardiovascular Systems
Heidi Allen, Bill J. Wright, Keri Vartanian, Kristen Dulacki, Hsin-Fang Li
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2019)
Article
Health Care Sciences & Services
Keri B. Vartanian, Hannah Cohen-Cline, Sheetal Kulkarni-Rajasekhara, Heather M. Polonsky, Bill Wright
POPULATION HEALTH MANAGEMENT
(2020)
Article
Health Care Sciences & Services
Caroline Cawley, Hannelore Buckenmeyer, Trina Jellison, Joseph B. Rinaldi, Keri B. Vartanian
JMIR MHEALTH AND UHEALTH
(2020)
Article
Public, Environmental & Occupational Health
Hannah Cohen-Cline, Hsin-Fang Li, Monique Gill, Fatima Rodriguez, Tina Hernandez-Boussard, Harry Wolberg, Jacob Lippa, Keri Vartanian
Summary: The study revealed that individuals whose preferred language is not English are at a higher risk of testing positive for COVID-19, even after adjusting for age, race/ethnicity, and social factors. This highlights a significant inequity in healthcare access and outcomes for non-English speakers.
Article
Multidisciplinary Sciences
Keri B. Vartanian, Megan Holtorf, Emily J. Cox, George Diaz, Hargobind Khurana, Sherene Schlegel, Caroline Raganit, Brandon Ong, Todd Czartoski
Summary: Background Telemedicine is a crucial response to COVID-19 in the healthcare system. This study examined the engagement, experience, and utilization patterns for English and Spanish-speaking patients involved in a telemedicine home monitoring program (HMP) for COVID-19. The results showed a high level of satisfaction and comfort among participants, and the program was associated with increased outpatient care and emergency department encounters. This highlights the importance of language-concordant telemedicine.
Article
Health Care Sciences & Services
Keri Vartanian, Daniel Fish, Benjamin Gronowski, Natalie Kenton, Ari Robicsek
Summary: This study aims to understand the physical, mental, and social health outcomes of fully vaccinated individuals who contracted COVID-19. The results show that the global physical and mental health scores increased over time and remained within one standard deviation of the population mean. At least 40% of participants reported good health for all component questions, and the proportion reporting good health increased over time for all questions.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
Article
Hematology
Christina U. Lorentz, Erik Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey Weitz, Andras Gruber
Summary: In patients with ESRD undergoing heparin-free hemodialysis, the use of the unique antibody AB023 can effectively reduce clotting within the dialyzer, maintaining good blood flow and potentially improving patient outcomes.
Article
Family Studies
Hannah Cohen-Cline, Kyle G. Jones, Sheetal Kulkarni-Rajasekhara, Heather M. Polonsky, Keri B. Vartanian
CHILD ABUSE & NEGLECT
(2019)