Article
Biochemistry & Molecular Biology
Lingxia Wang, Xixi Zhang, Haiwei Zhang, Kaili Lu, Ming Li, Xiaoming Li, Yangjing Ou, Xiaoming Zhao, Xiaoxia Wu, Xuanhui Wu, Jianling Liu, Mingyan Xing, Han Liu, Yue Zhang, Yongchang Tan, Fang Li, Xiaoxue Deng, Jiangshan Deng, Xiaojie Zhang, Jinbao Li, Yuwu Zhao, Qiurong Ding, Haikun Wang, Xiuzhe Wang, Yan Luo, Ben Zhou, Haibing Zhang
Summary: This study found that T-cell-specific Rip1 KO mice show age-related T cell changes and accelerated aging-like phenotypes. Rip1-deficient T cells undergo excessive apoptosis and promote chronic inflammation. Blocking apoptosis rescues T cell imbalance and aging-like phenotypes, prolonging lifespan.
Article
Genetics & Heredity
Suhao Han, Austin Sims, Anthony Aceto, Brigitte E. F. Schmidt, Marcel P. P. Bruchez, Aditi U. U. Gurkar
Summary: Oxidative DNA damage increases with age in all tissues, but to varying degrees. Researchers have developed a chemoptogenetic tool in Caenorhabditis elegans that can induce oxidative DNA damage and assess its effects on aging. By targeting a specific histone, they were able to induce DNA damage, leading to embryonic lethality, developmental delay, and reduced lifespan. This tool will allow researchers to study the role of DNA damage in aging at an organismal level.
Article
Biochemistry & Molecular Biology
Tingting Duan, Srikantha Thyagarajan, Anastasia Amoiroglou, Gregory C. Rogers, Pamela K. Geyer
Summary: This study demonstrates the importance of BAF protein in maintaining nuclear integrity, chromatin structure, and genome stability. By introducing the NGPS mutation in fruit flies, the researchers found that the progeroid BAF variant affects tissue homeostasis and leads to defects in germline stem cell mitosis and DNA damage. These findings link the phenotypes of NGPS patients to defects in cenBAF function, highlighting the critical role of BAF in establishing centromeric structures during mitosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Chunli Sha, Lu Chen, Li Lin, Taoqiong Li, Hong Wei, Meiling Yang, Wujiang Gao, Dan Zhao, Qi Chen, Yueqin Liu, Xiaofang Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: TRDMT1 plays a crucial role in repairing DNA damage caused by reactive oxygen species and regulates granulosa cell apoptosis in premature ovarian failure.
Article
Immunology
Zhendong Qin, Minxuan Yang, Zhijie Lu, V. Sarath Babu, Yanan Li, Fei Shi, Fanbin Zhan, Chun Liu, Jun Li, Li Lin
Summary: Intravascular hemolysis leads to accumulation of hemoglobin and iron, activation of antioxidant system, and tissue oxidative damage in grass carp. The study suggests that excess of released Hb from hemolysis may be associated with ROS and inflammation generation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lixi Shi, Yinghui Ji, Shufan Zhao, Houxuan Li, Yun Jiang, Jiajie Mao, Yang Chen, Xiaorong Zhang, Yixin Mao, Xiaoyu Sun, Panpan Wang, Jianfeng Ma, Shengbin Huang
Summary: The excessive generation of reactive oxygen species (ROS) has significant impacts on the development of periodontitis. The crosstalk between ROS and Drp1 plays a crucial role in promoting the progression of periodontitis. Pharmacological blockade of this crosstalk may offer a novel therapeutic strategy for periodontitis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Editorial Material
Cell Biology
Irene Franco, Gwladys Revechon, Maria Eriksson
Summary: The causal effects of somatic mutations in the aging process are still not clear due to technological and methodological weaknesses. Studying somatic mutagenesis in different experimental systems can help understand its functional role.
Review
Oncology
Winnie M. C. van den Boogaard, Daphne S. J. Komninos, Wilbert P. Vermeij
Summary: Recent advances in cancer treatment have increased survival rates, but the negative lasting effects of treatment can lead to accelerated aging in cancer survivors. Chemotherapeutic drugs target and damage DNA, causing mutations and genome instability, which can affect cell cycle, differentiation status, and cellular micro-environment, ultimately influencing the outcomes of cancer treatment.
Article
Cell Biology
Ying Ao, Zhuping Wu, Zhiwei Liao, Juncong Lan, Jie Zhang, Pengfei Sun, Baohua Liu, Zimei Wang
Summary: The nuclear matrix protein lamin A plays multiple roles in the cell, including DNA replication and repair, gene activation, transcriptional regulation, and maintenance of chromatin structure. Phosphorylation of lamin A determines its mobility in the nucleus and nuclear membrane dissolution. This study investigates the regulation of lamin A phosphorylation during interphase and demonstrates that C-terminal mutations can induce cellular senescence. The results suggest that phosphorylation at specific C-terminal sites is crucial for genomic stability and prevention of cellular senescence.
Article
Toxicology
Deyi Wu, Meng Zhang, Ting Ting Bao, Hainan Lan
Summary: In this study, the effect of polystyrene microplastics (PS-MPs) on premature testicular aging was investigated in vitro and in vivo. The results showed that PS-MPs induced premature senescence of testicular cells through the activation of NF-kappa B by ROS. In vivo experiments confirmed that PS-MPs exposure caused premature aging of testicular tissue, accompanied by oxidative stress and inflammatory response.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Review
Genetics & Heredity
Hayden A. Homer
Summary: Premature ovarian aging (POA) and premature ovarian insufficiency (POI) are caused by reduced ovarian reserve, with the integrity of oocyte DNA playing a critical role in preventing these conditions. The RNA/DNA helicase Senataxin (SETX) has been found to protect oocyte DNA integrity against aging-induced oxidative stress, preventing premature depletion of the ovarian follicular pool and reducing low-grade DNA damage in oocytes.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Bruna Ribeiro Andrade Ramos, Julia Abbade Tronco, Marcio Carvalho, Tainara Francini Felix, Patricia Pintor Reis, Juliano Coelho Silveira, Marcia Guimaraes Silva
Summary: This study compared the expression of miRNAs in sEV from peripheral blood between term and preterm pregnancies. It found that miR-612 expression was increased in the preterm group, while miR-1253, miR-1283, miR378e, and miR-579-3p were downregulated in the preterm premature rupture of membranes (PPROM) group. The study suggests that miRNAs in circulating sEV play a regulatory role in the pathogenesis of preterm labor (PTL) and PPROM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Qinghao Li, Man Zhang, Juan Sun, Yilei Li, Shaopo Zu, Yuqiang Xiang, Xin Jin
Summary: This study investigated the molecular mechanisms of pBD-2 in alleviating AFB1-induced oxidative stress and intestinal mucosal damage. The findings revealed that pBD-2 reduced ROS production, decreased inflammatory response, and restored intestinal mucosal barrier function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Ioannis K. Koutsaliaris, Iraklis C. Moschonas, Louisa M. Pechlivani, Aikaterini N. Tsouka, Alexandros D. Tselepis
Summary: Vascular aging is a crucial risk factor for atherosclerotic ischemic stroke, characterized by oxidative stress, inflammation, and arterial stiffness. Oxidative stress and inflammation play important roles in vascular aging and atherosclerotic ischemic stroke.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Michela Murdocca, Paola Spitalieri, Angela Cappello, Fiorella Colasuonno, Sandra Moreno, Eleonora Candi, Maria Rosaria D'Apice, Giuseppe Novelli, Federica Sangiuolo
Summary: MDPL Syndrome is a rare genetic premature aging disease characterized by mandibular hypoplasia, deafness, progeroid features, and concomitant lipodystrophy. In this study, the role of mitochondrial metabolism and activity in the pathogenesis of MDPL Syndrome was investigated. The results demonstrated a significant impairment of mitochondrial biogenesis and activity in MDPL cells, accompanied by increased production of reactive oxygen species (ROS). While Metformin was unable to restore mitochondrial impairment, it showed efficacy in rescuing nuclear abnormalities associated with the premature aging phenotype.