Article
Multidisciplinary Sciences
Youwen Zhuang, Lei Wang, Jia Guo, Dapeng Sun, Yue Wang, Weiyi Liu, H. Eric Xu, Cheng Zhang
Summary: The study presents cryo-EM structures of formylpeptide receptors FPR1 and FPR2 bound to different agonists and Gi protein, providing insights into the recognition of formylpeptides and synthetic agonists by FPRs and their activation mechanism. This research has significant implications for the rational design of drugs targeting FPRs.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Sonja Dorfer, Katharina Strasser, Siegfried Reipert, Michael B. Fischer, Saeed Shafti-Keramat, Michael Bonelli, Georg Schroeckenfuchs, Wolfgang Bauer, Stefanie Kancz, Lena Mueller, Alessandra Handisurya
Summary: The research found that CRAMP has a certain degree of effect in combating papillomavirus, but primarily protects mice from skin infection with Mus musculus papillomavirus 1 by modulating cellular and humoral immune responses. Differences were observed in the immune response and disease development after infection between the control group and CRAMP-deficient mice.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Biology
Murat Kilinc, Vineet Arora, Thomas K. Creson, Camilo Rojas, Aliza A. Le, Julie Lauterborn, Brent Wilkinson, Nicolas Hartel, Nicholas Graham, Adrian Reich, Gemma Gou, Yoichi Araki, Alex Bayes, Marcelo Coba, Gary Lynch, Courtney A. Miller, Gavin Rumbaugh
Summary: Loss-of-function variants in SYNGAP1 cause cognitive impairment, autistic features, and epilepsy. Different splice sequences regulate neuronal function and behavior. Specific mutations can lead to severe phenotypes, and upregulation or downregulation of expression can improve learning ability and seizure.
Review
Veterinary Sciences
Yewande O. Fasina, Temitayo Obanla, George Dosu, Sierra Muzquiz
Summary: AMPs, as a critical part of the host's innate immune system, have been shown to have protective effects in the gastrointestinal tract of food animals. Despite limitations, AMPs exhibit broad-spectrum antibacterial activity and reduce the acquisition of resistance genes by bacteria, suggesting them as potential alternatives to antibiotics in livestock industries.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Ruyan Feng, Lijuan Zhu, Xingyu Heng, Gaojian Chen, Hong Chen
Summary: Research has shown that short-chain glycopolymers demonstrate better binding ability to immune-related proteins and enhanced promotion of dendritic cell maturation compared to long-chain glycopolymers. By combining experimental characterization and theoretical simulation, a deeper understanding of the interaction between glycopolymers with different chain lengths and immune-related proteins is achieved, providing a solid theoretical basis for the design of new glycopolymer-based immune drugs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Microbiology
Reiner Noschka, Fabian Gerbl, Florian Loeffler, Jan Kubis, Armando A. Rodriguez, Daniel Mayer, Mark Grieshober, Armin Holch, Martina Raasholm, Wolf-Georg Forssmann, Barbara Spellerberg, Sebastian Wiese, Gilbert Weidinger, Ludger Staendker, Steffen Stenger
Summary: Research has identified Angiogenin as a novel endogenous antimicrobial peptide, with the fragment Angie1 showing potential therapeutic activity against tuberculosis and fast-growing bacterial pathogens.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Yang Zhang, Peng Cheng, Shiyuan Wang, Xiaofen Li, Lianci Peng, Rendong Fang, Jing Xiong, Hui Li, Cui Mei, Jiye Gao, Zhenhui Song, Dengfeng Xu, Lizhi Fu, Chenghong Li, Xueqing Wu, Yuzhang He, Hongwei Chen
Summary: This study investigates the potential mechanism by which CRAMP eradicates P. aeruginosa biofilms through an integrative analysis of transcriptomic, proteomic, and metabolomic data. The omics data reveal that CRAMP functions against P. aeruginosa biofilms through different pathways, including the PQS system, c-di-GMP signaling pathway, and synthesis pathways of exopolysaccharides and rhamnolipid. The study provides new insight into the development of CRAMP as a potentially effective antibiofilm dispersant.
VETERINARY RESEARCH
(2022)
Article
Immunology
Rafael Tiburcio, Leon Dimitri Melo, Sara Nunes, Ana Luisa Augusto Barbosa, Elaine Carvalho de Oliveira, Martha Suarez, Valeria M. Borges, Natalia Tavares, Claudia Ida Brodskyn
Summary: This study focused on the interaction between PMNs and infected DCs in an in vitro model of Leishmania amazonensis infection. It was found that infected DCs showed lower infection rates when co-cultured with resting or activated PMNs. The release of neutrophil enzymes was not involved in parasite killing, and the interaction between PMNs and infected DCs was mediated by DC-SIGN. This study highlights the importance of direct contact between PMNs and infected DCs via DC-SIGN for the production of inflammatory mediators and subsequent parasite elimination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuning Zhang, Joakim Hakansson, Yanmiao Fan, Oliver C. J. Andren, Jorge San Jacinto Garcia, Liguo Qin, Anita Umerska, Daniel J. Hutchinson, Mads Luchow, Margit Mahlapuu, Michael Malkoch
Summary: A hybrid hierarchical delivery system for topical delivery of antimicrobial peptides (AMPs) was developed by incorporating AMPs into dendritic nanogels (DNGs) and embedding them into poloxamer gel. The system exhibited a slower release rate compared to direct entrapment in the gels, and showed good biocompatibility and strong antibacterial effects against Staphylococcus aureus.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Immunology
Yolanda Garcia-Carmona, Miguel Fribourg, Allison Sowa, Andrea Cerutti, Charlotte Cunningham-Rundles
Summary: While mouse B cells and human B cells express different TACI isoforms, only TACI-S promotes terminal B cell differentiation into plasma cells. The expression of intracellular TACI-S increases with B cell activation, and it colocalizes with BCMA and their ligand, APRIL. Loss of APRIL impairs isotype class switch and leads to distinct metabolic and transcriptional changes, suggesting that intracellular TACI-S along with APRIL and BCMA are important for long-term plasma cell differentiation and survival.
CLINICAL IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Johnson John, Navatha Shree Sharma, Guosheng Tang, Zeyu Luo, Yajuan Su, Shelbie Weihs, S. M. Shatil Shahriar, Guangshun Wang, Alec McCarthy, Justin Dyke, Yu Shrike Zhang, Ali Khademhosseini, Jingwei Xie
Summary: This study introduces a strategy to use nanofiber aerogels combined with the LL-37-mimic peptide W379 for accelerated healing of diabetic wounds, showing great potential for clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Youssof Eshac, Rachel L. Redfern, Vinay Kumar Aakalu
Summary: The ocular surface is responsible for maintaining a clear moist refractive surface and protecting the eye from exogenous pathogens, with antimicrobial peptides playing a crucial role in the immune response during both healthy states and dry eye diseases. These peptides have various functions such as neutralizing microbial threats, promoting wound healing, and modulating immunity, making them potential therapeutic targets for ocular surface diseases and dry eye.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kyung-No Son, Hyun Lee, Dhara Shah, Sushma Kalmodia, Ryan Cree Miller, Marwan Ali, Arun Balasubramaniam, Stephanie M. Cologna, Hyunjoon Kong, Deepak Shukla, Vinay Kumar Aakalu
Summary: The Sigma-2 receptor (S2R) is an important endoplasmic reticular protein, with Histatin-1 (Hst1) being its endogenous ligand. Hst1 plays important roles in epithelial wound healing and cell migration.
Article
Biochemistry & Molecular Biology
Nikhil N. Kulkarni, Alan M. O'Neill, Tatsuya Dokoshi, Elizabeth W. C. Luo, Gerard C. L. Wong, Richard L. Gallo
Summary: Cathelicidins like LL-37 have dual functions in killing microbes and triggering inflammation by recognizing endogenous nucleic acids. Variants of LL-34 showed different antimicrobial and interferon expression capabilities. LL-34 and U1 RNA form supramolecular structures, activating Toll-like receptor 3.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Immunology
Johnathan Canton, Hanna Blees, Conor M. Henry, Michael D. Buck, Oliver Schulz, Neil C. Rogers, Eleanor Childs, Santiago Zelenay, Hefin Rhys, Marie-Charlotte Domart, Lucy Collinson, Andres Alloatti, Cara J. Ellison, Sebastian Amigorena, Venizelos Papayannopoulos, David C. Thomas, Felix Randow, Caetano Reis e Sousa
Summary: DNGR-1 is a dedicated cross-presentation receptor that promotes phagosomal rupture, allowing corpse-associated antigens to access the major histocompatibility complex class I antigen processing pathway. This mechanism reveals the existence of innate immune receptors that couple ligand binding and endocytic vesicle damage to regulate adaptive immunity.
Article
Environmental Sciences
Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhang
Summary: Cadmium (Cd) is an environmental contaminant known for its potential toxicity, particularly in accumulating in the liver and kidney and causing serious damage. In this study, Cd-induced intestinal damage in swine was investigated through in vivo and in vitro models. The research found that Cd treatment induced ileal apoptosis and autophagy in cells, activating the PI3K/Akt pathway, and altering expression levels of apoptosis and autophagy-related proteins. Furthermore, the study showed that treatment with a PI3K activator could mitigate the effects of Cd-induced apoptosis and autophagy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Jianyang Wang, Linkuo Shang, Jiahui Zhang, Zhengquan Yu, Jiaqiang Huang, Jing Jin, Cong Lv
Summary: In this study, a new population of NFATc1(+) colonic stem cells was identified and shown to play a critical role in epithelial regeneration during colitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yanhua Guo, Jiaqiang Huang, Kui Yu, Guoqing Dai, Zhonggang Sun, Hui Chang
Summary: This study fabricated 0.5 wt% Ni-P@GNF/ Ti-6Al-4V composites with different particle sizes using chemical nickel plating and plasma sintering, and found that the addition of graphene nanosheets improved the compressive strength of Ti-6Al-4V. With increasing spherical powder particle size, the size of the reinforcing phase of the network structure coarsened and the plasticity was enhanced.
MATERIALS CHARACTERIZATION
(2022)
Article
Chemistry, Multidisciplinary
Rui Zhou, Zhen Hou, Qun Liu, Xiaoqiong Du, Jiaqiang Huang, Biao Zhang
Summary: Calcium-ion batteries have promising potential as multivalent ion battery systems, and selenium has been explored as a reliable electrode material. Selenium demonstrates high energy density and long-term cyclic stability, making it suitable for both non-aqueous and aqueous electrolytes.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Mathematical & Computational Biology
Hong Xia, Jiaqiang Huang, Jian Liu, Hua Zhang, Dawei Chen, Wen Zhang, Xianghong Zhou, Zhouyang Wei, Zhaoxiang Liu
Summary: Levetiracetam can alleviate motor dysfunctions caused by spinal cord injury by reducing nerve cell injury, inflammation, blood-spinal cord barrier permeability, and inhibiting perforin expression.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Engineering, Electrical & Electronic
Jiaqiang Huang, Xudong Wang, Junyu Chen, Weichun Wei, Fengmei Liu, Binhao Qin, Haiyan Wang, Yupeng Zhang
Summary: Sn-58Bi solder has gained attention due to its low melting temperature and cost, but there are reliability issues related to local melting. This study comprehensively investigates the growth mechanisms of interfacial intermetallic compounds (IMCs) and Bi-rich layer in Cu/Sn-58Bi/Cu joints during solid-solid and liquid-solid electromigration. The results show that the growth of IMCs and the presence of a Bi-rich layer are influenced by temperature and current stressing.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Electrochemistry
Julien Bonefacino, Sasan Ghashghaie, Tianye Zheng, Chun-Pang Lin, Wenwei Zheng, Laura Albero Blanquer, Jiaqiang Huang, Charlotte Gervillie, Hwa-Yaw Tam, Jean-Marie Tarascon, Steven T. Boles
Summary: The convergence of fiber optic sensing with lithium-ion batteries enables real-time observation of key cell parameters. Fiber Bragg gratings can be used to measure these metrics and can be extended to polymeric optical fibers. Pairing a polymer optical fiber sensor with a silica-based sensor allows for simultaneous measurement of temperature and volumetric expansion data.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Jia-Qiang Huang, Yun-Yun Jiang, Fa-Zheng Ren, Xin Gen Lei
Summary: This study demonstrates that the depletion of glutathione peroxidase 4 (GPX4) protein is a major contributor to the development of nutritional pancreatic atrophy (NPA), and this mechanism is related to the binding of GPX4 to prothymosin alpha (ProTalpha).
Article
Chemistry, Physical
Parth Desai, Jiaqiang Huang, Dominique Foix, Jean-Marie Tarascon, Sathiya Mariyappan
Summary: Although sodium-ion batteries cannot compete with lithium-ion batteries in terms of energy density, their importance is increasing due to advantages such as 0 V stability. However, the rise in negative electrode potential may cause interphase instability, requiring careful selection of cell chemistry to achieve 0 V stable sodium-ion cells.
JOURNAL OF POWER SOURCES
(2022)
Article
Energy & Fuels
C. Gervillie-Mouravieff, C. Boussard-Pledel, Jiaqiang Huang, C. Leau, L. Albero Blanquer, M. Ben Yahia, M-L Doublet, S. T. Boles, X. H. Zhang, J. L. Adam, J-M Tarascon
Summary: A new method for monitoring the dynamic chemistry inside batteries using operando infrared spectroscopy and optical fiber sensors has been developed. This method reveals the dynamic mechanisms of key processes in commercial Li-ion and Na-ion batteries.
Article
Oncology
Yuze Wang, Toshiaki Ohara, Yuehua Chen, Yusuke Hamada, Chunning Li, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa
Summary: Excess iron is a risk factor for carcinogenesis, but iron chelators have not been successfully used to treat cancer patients. This study found that iron chelators could have therapeutic potential for triple-negative breast cancer (TNBC). The iron chelator Deferasirox suppressed the growth of TNBC cells and reduced lung metastases in mouse models. Highly metastatic TNBC cells have limited iron metabolism and are more susceptible to iron chelators.
Article
Biochemistry & Molecular Biology
Tong Gao, Xu Yang, Masayoshi Fujisawa, Toshiaki Ohara, Tianyi Wang, Nahoko Tomonobu, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa
Summary: The downregulation of SPRED2 promotes EMT and stemness in hepatocellular carcinoma through the activation of the ERK1/2 pathway, leading to more malignant phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Guangliang Zhang, Zhiqiang Zhang, Gaobiao Cao, Qianheng Jin, Lei Xu, Jiaying Li, Zhe Liu, Chi Xu, Yingying Le, Yi Fu, Jihui Ju, Bin Li, Ruixing Hou
Summary: This study explored the application of GelMA-HAMA-fibrin scaffold in 3D bioprinting, which can promote vascularisation and wound healing under confined force loading, providing new treatment methods for tissue engineering.
ACTA BIOMATERIALIA
(2023)
Article
Optics
Wu Fan, Wan Guilin, Yang Yang, Huang Jiaqiang, Chen Wei, Sun Zhonggang
Summary: This study focuses on the friction stirring welding technology to fabricate a novel gradient-structured aluminum alloy successfully. The aluminum alloy prepared through friction stirring technology exhibits fine grain sizes, uniform microstructure, and high hardness, which can be further improved after aging treatment. The results demonstrate that gradient alloys with comprehensive mechanical properties can be achieved through rational design and innovative manufacturing techniques.
CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG
(2022)
Article
Oncology
Shuye Lin, Hanli Xu, Mengdi Pang, Xiaomeng Zhou, Yuanming Pan, Lishu Zhang, Xin Guan, Xiaoyue Wang, Bonan Lin, Rongmeng Tian, Keqiang Chen, Xiaochen Zhang, Zijiang Yang, Fengmin Ji, Yingying Huang, Wu Wei, Wanghua Gong, Jianke Ren, Ji Ming Wang, Mingzhou Guo, Jiaqiang Huang
Summary: This study provides the first evidence for the transcriptional and functional characterization of PRSS3 transcripts in HCC. Aberrant expression of divergent PRSS3 splice variants disrupted by site-specific CpG methylation may integrate the effects of oncogenic PRSS3-V2 and tumor-suppressive PRSS3-V1, resulting in the molecular diversity and functional plasticity of PRSS3 in HCC. Dysregulated expression of PRSS3-V2 by site-specific CpG methylation may have potential diagnostic value for patients with early HCC.
FRONTIERS IN ONCOLOGY
(2022)
