Yeast Cells Expressing the Human Mitochondrial DNA Polymerase Reveal Correlations between Polymerase Fidelity and Human Disease Progression

Towards Efficient Reconstitution of the Human Mitochondrial DNA Replication Complex

(2013) Yufeng Qian et al.   BIOPHYSICAL JOURNAL

Contemporary, yeast-based approaches to understanding human genetic variation

(2013) Maitreya J Dunham et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Benefits of Humanized Yeast Models to Study Parkinson’s Disease

(2013) V. Franssens et al.   Oxidative Medicine and Cellular Longevity

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Mutations in human DNA polymerase   confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients

(2012) C. D. Sohl et al.   HUMAN MOLECULAR GENETICS

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Effect of the Y955C Mutation on Mitochondrial DNA Polymerase Nucleotide Incorporation Efficiency and Fidelity

(2011) Patricia A. Estep et al.   BIOCHEMISTRY

Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia†

(2011) Neli Atanassova et al.   HUMAN MOLECULAR GENETICS

Mitochondrial DNA polymerase   mutations: an ever expanding molecular and clinical spectrum

(2011) S. Tang et al.   JOURNAL OF MEDICAL GENETICS

Biochemical analysis of the G517V POLG variant reveals wild-type like activity

(2011) Rajesh Kasiviswanathan et al.   MITOCHONDRION

A Novel POLG Gene Mutation in 4 Children With Alpers-like Hepatocerebral Syndromes

(2010) Bulent Kurt et al.   ARCHIVES OF NEUROLOGY

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations

(2010) Jeffrey D. Stumpf et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial diseases and the role of the yeast models

(2010) Teresa Rinaldi et al.   FEMS YEAST RESEARCH

mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae

(2010) J. D. Stumpf et al.   HUMAN MOLECULAR GENETICS

A cluster of pathogenic mutations in the 3′–5′ exonuclease domain of DNA polymerase gamma defines a novel module coupling DNA synthesis and degradation

(2010) Karolina Szczepanowska et al.   HUMAN MOLECULAR GENETICS

Role of Histidine 932 of the Human Mitochondrial DNA Polymerase in Nucleotide Discrimination and Inherited Disease

(2010) Dipanwita Batabyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late-onset ptosis and myopathy in a patient with a heterozygous insertion in POLG2

(2010) Maggie C. Walter et al.   JOURNAL OF NEUROLOGY

Yeast mitochondrial DNA polymerase is a highly processive single-subunit enzyme

(2010) Katrin Viikov et al.   MITOCHONDRION

Predicting the contribution of novel POLG mutations to human disease through analysis in yeast model

(2010) Enrico Baruffini et al.   MITOCHONDRION

Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2genes in yeast

(2009) Matjaz Vogelsang et al.   BMC CANCER

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

(2009) Young-Sam Lee et al.   CELL

Each Monomer of the Dimeric Accessory Protein for Human Mitochondrial DNA Polymerase Has a Distinct Role in Conferring Processivity

(2009) Young-Sam Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae

(2009) Sandra Merz et al.   GENOME BIOLOGY

Progressive External Ophthalmoplegia and Vision and Hearing Loss in a Patient With Mutations in POLG2 and OPA1

(2008) Silvio Ferraris et al.   ARCHIVES OF NEUROLOGY

Protein folding diseases and neurodegeneration: Lessons learned from yeast

(2008) Joris Winderickx et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inherited Mitochondrial Diseases of DNA Replication

(2007) William C. Copeland   Annual Review of Medicine