Multiple Drugs Compete for Transport via thePlasmodium falciparumChloroquine Resistance Transporter at Distinct but Interdependent Sites

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

(2014) R. L. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

(2013) Christine A. Hrycyna et al.   ACS Chemical Biology

Understanding allosteric and cooperative interactions in enzymes

(2013) Athel Cornish-Bowden   FEBS Journal

Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein

(2013) Lorena Martinez et al.   FEBS Journal

Induced fit substrate binding to an archeal glutamate transporter homologue

(2013) D. Ewers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

(2012) Robert L. Summers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

(2012) Janni Papakrivos et al.   PLoS One

PfCRT and its role in antimalarial drug resistance

(2012) Andrea Ecker et al.   TRENDS IN PARASITOLOGY

In vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr1 genes of Plasmodium falciparum isolates from Nigeria

(2011) O.A. Folarin et al.   ACTA TROPICA

Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites

(2011) Richard T. Eastman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

(2011) Jane Achan et al.   MALARIA JOURNAL

Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

(2011) Cecilia P. Sanchez et al.   MOLECULAR MICROBIOLOGY

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

Transporters as mediators of drug resistance in Plasmodium falciparum

(2010) Cecilia P. Sanchez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Similar Efficacy and Tolerability of Double-Dose Chloroquine and Artemether-Lumefantrine for Treatment of Plasmodium falciparum Infection in Guinea-Bissau: A Randomized Trial

(2010) Johan Ursing et al.   JOURNAL OF INFECTIOUS DISEASES

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

(2009) R. E. Martin et al.   SCIENCE

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Chloroquine Resistance-Conferring Mutations in pfcrt Give Rise to a Chloroquine-Associated H+ Leak from the Malaria Parasite's Digestive Vacuole

(2008) A. M. Lehane et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

(2008) A. M. Lehane et al.   JOURNAL OF CELL SCIENCE