Overlapping Binding Sites of the Frataxin Homologue Assembly Factor and the Heat Shock Protein 70 Transfer Factor on the Isu Iron-Sulfur Cluster Scaffold Protein

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry

(2014) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Chronochemistry in neurodegeneration

(2014) Annalisa Pastore et al.   Frontiers in Molecular Neuroscience

Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation

(2014) Alain Martelli et al.   Frontiers in Pharmacology

Frataxin Directly Stimulates Mitochondrial Cysteine Desulfurase by Exposing Substrate-binding Sites, and a Mutant Fe-S Cluster Scaffold Protein with Frataxin-bypassing Ability Acts Similarly

(2013) Alok Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferredoxin Competes with Bacterial Frataxin in Binding to the Desulfurase IscS

(2013) Robert Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of the Chaperone Jac1 Protein and Cysteine Desulfurase Nfs1 to the Iron-Sulfur Cluster Scaffold Isu Protein Is Mutually Exclusive

(2013) Julia Majewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

[2Fe-2S]-Ferredoxin Binds Directly to Cysteine Desulfurase and Supplies an Electron for Iron–Sulfur Cluster Assembly but Is Displaced by the Scaffold Protein or Bacterial Frataxin

(2013) Jin Hae Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Role of Mitochondria in Cellular Iron-Sulfur Protein Biogenesis: Mechanisms, Connected Processes, and Diseases

(2013) O. Stehling et al.   Cold Spring Harbor Perspectives in Biology

(IscS-IscU)2Complex Structures Provide Insights into Fe2S2Biogenesis and Transfer

(2012) Elodie N. Marinoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe–S cluster synthesis

(2012) Alok Pandey et al.   BIOCHEMICAL JOURNAL

Effector Role Reversal during Evolution: The Case of Frataxin in Fe–S Cluster Biosynthesis

(2012) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

(2012) Roland Lill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Missense Mutations Linked to Friedreich Ataxia Have Different but Synergistic Effects on Mitochondrial Frataxin Isoforms

(2012) Hongqiao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of J-Protein Co-Chaperone Jac1 with Fe–S Scaffold Isu Is Indispensable In Vivo and Conserved in Evolution

(2012) Szymon J. Ciesielski et al.   JOURNAL OF MOLECULAR BIOLOGY

Mammalian Frataxin Controls Sulfur Production and Iron Entry during de Novo Fe4S4 Cluster Assembly

(2012) Florent Colin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron–sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia

(2012) Rachael A. Vaubel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Friedreich’s Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron–Sulfur Cluster Assembly Complex

(2011) Chi-Lin Tsai et al.   BIOCHEMISTRY

Structure–Function Analysis of Friedreich’s Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe–S Assembly Complex

(2011) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Facilitated Transfer of IscU–[2Fe2S] Clusters by Chaperone-Mediated Ligand Exchange

(2011) Francesco Bonomi et al.   BIOCHEMISTRY

Primary Sequence That Determines the Functional Overlap between Mitochondrial Heat Shock Protein 70 Ssc1 and Ssc3 ofSaccharomyces cerevisiae

(2011) Gautam Pareek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

InterPro in 2011: new developments in the family and domain prediction database

(2011) S. Hunter et al.   NUCLEIC ACIDS RESEARCH

Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex

(2011) Stéphane Schmucker et al.   PLoS One

Molecular Details of the Yeast Frataxin−Isu1 Interaction during Mitochondrial Fe−S Cluster Assembly

(2010) Jeremy D. Cook et al.   BIOCHEMISTRY

Human Frataxin Is an Allosteric Switch That Activates the Fe−S Cluster Biosynthetic Complex

(2010) Chi-Lin Tsai et al.   BIOCHEMISTRY

Frataxin and Mitochondrial FeS Cluster Biogenesis

(2010) Timothy L. Stemmler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

(2010) Filippo Prischi et al.   Nature Communications

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

(2010) Rong Shi et al.   PLOS BIOLOGY

Structure and Dynamics of the Iron−Sulfur Cluster Assembly Scaffold Protein IscU and Its Interaction with the Cochaperone HscB

(2009) Jin Hae Kim et al.   BIOCHEMISTRY

Frataxin interacts with Isu1 through a conserved tryptophan in its β-sheet

(2009) Sébastien Leidgens et al.   HUMAN MOLECULAR GENETICS

Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis

(2009) Y. Shi et al.   HUMAN MOLECULAR GENETICS

Oligomeric Yeast Frataxin Drives Assembly of Core Machinery for Mitochondrial Iron-Sulfur Cluster Synthesis

(2009) Hongqiao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Targeting of Nfs1 and Discovery of Its Novel Processing Enzyme, Icp55

(2009) Adi Naamati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of the Iron−Sulfur Cluster Cochaperone HscB and Its Binding Surface for the Iron−Sulfur Assembly Scaffold Protein IscU†‡

(2008) Anna K. Füzéry et al.   BIOCHEMISTRY

Studies on the Mechanism of Catalysis of Iron−Sulfur Cluster Transfer from IscU[2Fe2S] by HscA/HscB Chaperones†

(2008) Francesco Bonomi et al.   BIOCHEMISTRY

Binding of Yeast Frataxin to the Scaffold for Fe-S Cluster Biogenesis, Isu

(2008) Tao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY