Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Tweezers with Varying Anions: A Comparative Study

(2013) Som Dutt et al.   JOURNAL OF ORGANIC CHEMISTRY

Molecular tweezers modulate 14-3-3 protein–protein interactions

(2013) David Bier et al.   Nature Chemistry

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Prevents Aggregation in α-Synuclein by Increasing Reconfiguration Rate

(2012) Basir Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

Aggregation of  -synuclein is kinetically controlled by intramolecular diffusion

(2012) B. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Molecule Characterization of α-Synuclein in Aggregation-Prone States

(2010) Adam J. Trexler et al.   BIOPHYSICAL JOURNAL

Top-down mass spectrometry of supercharged native protein–ligand complexes

(2010) Sheng Yin et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

A General Polymer Model of Unfolded Proteins under Folding Conditions

(2010) Yujie Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Elucidating the site of protein-ATP binding by top-down mass spectrometry

(2010) Sheng Yin et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE