Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors

P66Shc signals to age

(2016) Mirella Trinei et al.   Aging-US

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

(2013) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXOs attenuate bone formation by suppressing Wnt signaling

(2013) Srividhya Iyer et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

The role of estrogen and androgen receptors in bone health and disease

(2013) Stavros C. Manolagas et al.   Nature Reviews Endocrinology

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual

(2012) Maria Almeida et al.   JOURNAL OF CLINICAL INVESTIGATION

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

Unraveling the role of FoxOs in bone—Insights from mouse models

(2011) Maria Almeida   BONE

Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor

(2011) Einav Cohen-Kfir et al.   ENDOCRINOLOGY

Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat

(2011) Iman Momken et al.   FASEB JOURNAL

Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer

(2011) R L Moore et al.   JOURNAL OF ENDOCRINOLOGY

Building strong bones: molecular regulation of the osteoblast lineage

(2011) Fanxin Long   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual

(2011) Rachel A. Davey et al.   TRANSGENIC RESEARCH

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

(2010) Chiao-Po Hsu et al.   CIRCULATION

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

(2010) K. R. Holloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

The Transcription of FOXO Genes Is Stimulated by FOXO3 and Repressed by Growth Factors

(2009) Ahmed Essaghir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

(2008) Diana Hoogeboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY