Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4

(2013) Kale S. Bongers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms regulating skeletal muscle growth and atrophy

(2013) Stefano Schiaffino et al.   FEBS Journal

Anticarcinogenic, Cardioprotective, and Other Health Benefits of Tomato Compounds Lycopene, α-Tomatine, and Tomatidine in Pure Form and in Fresh and Processed Tomatoes

(2013) Mendel Friedman   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Yin Yang 1 Deficiency in Skeletal Muscle Protects against Rapamycin-Induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling

(2012) Sharon M. Blättler et al.   Cell Metabolism

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

(2012) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A long-term comparison of the influence of organic and conventional crop management practices on the content of the glycoalkaloidα-tomatine in tomatoes

(2012) Eunmi Koh et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

(2012) Steven D. Kunkel et al.   PLoS One

Rapid Determination of Myosin Heavy Chain Expression in Rat, Mouse, and Human Skeletal Muscle Using Multicolor Immunofluorescence Analysis

(2012) Darin Bloemberg et al.   PLoS One

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

(2011) Steven D. Kunkel et al.   Cell Metabolism

Tomatidine, a Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting Acyl-CoA:cholesterol Acyl-transferase (ACAT)

(2011) Yukio Fujiwara et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia

(2011) T. N. Burks et al.   Science Translational Medicine

Differential atrophy of the lower-limb musculature during prolonged bed-rest

(2009) Daniel L. Belavý et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

A novel hindlimb immobilization procedure for studying skeletal muscle atrophy and recovery in mouse

(2009) Annabelle Z. Caron et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

(2008) Yasuhiro Izumiya et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Cachexia: prevalence and impact in medicine

(2008) Benjamin HL Tan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE