DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase

Helicase and Polymerase Move Together Close to the Fork Junction and Copy DNA in One-Nucleotide Steps

(2014) Manjula Pandey et al.   Cell Reports

Mutations in DNA2 Link Progressive Myopathy to Mitochondrial DNA Instability

(2013) Dario Ronchi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial genome changes and neurodegenerative diseases

(2013) Milena Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Subnormal levels of POLγA cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and autosomal dominant progressive external ophthalmoplegia

(2013) Sara Roos et al.   HUMAN MOLECULAR GENETICS

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of Homologous Recombination and Implications for Aging-Related Deletions in Mitochondrial DNA

(2013) X. J. Chen   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands

(2013) Ting-Yuan Tseng et al.   NUCLEIC ACIDS RESEARCH

Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication

(2013) N. Rajala et al.   NUCLEIC ACIDS RESEARCH

An Appraisal of Human Mitochondrial DNA Instability: New Insights into the Role of Non-Canonical DNA Structures and Sequence Motifs

(2013) Pedro H. Oliveira et al.   PLoS One

G-quadruplex structures are stable and detectable in human genomic DNA

(2013) Enid Yi Ni Lam et al.   Nature Communications

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences

(2013) Sara Zapico   Aging and Disease

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

(2012) N. Sabouri et al.   GENES & DEVELOPMENT

DNA Repair and Replication Fork Helicases Are Differentially Affected by Alkyl Phosphotriester Lesion

(2012) Avvaru N. Suhasini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Q Motif of Fanconi Anemia Group J Protein (FANCJ) DNA Helicase Regulates Its Dimerization, DNA Binding, and DNA Repair Function

(2012) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Mitochondrial DNA Helicase TWINKLE Is Both an Unwinding and Annealing Helicase

(2012) Doyel Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

(2012) P. H. Wanrooij et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA deletions are associated with non-B DNA conformations

(2012) Joana Damas et al.   NUCLEIC ACIDS RESEARCH

Association of Mitochondrial DNA Variations with Lung Cancer Risk in a Han Chinese Population from Southwestern China

(2012) Shizhen Zheng et al.   PLoS One

Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces cerevisiae Depends on G-Quadruplexes or Cdc13

(2012) Aurèle Piazza et al.   PLoS Genetics

The interface of transcription and DNA replication in the mitochondria

(2011) Rajesh Kasiviswanathan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Defects in mitochondrial DNA replication and human disease

(2011) William C. Copeland   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

The generation of mitochondrial DNA large-scale deletions in human cells

(2011) Tao Chen et al.   JOURNAL OF HUMAN GENETICS

Mitochondrial DNA and disease

(2011) Laura C Greaves et al.   JOURNAL OF PATHOLOGY

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

A case of Kearns–Sayre syndrome with two novel deletions (9.768 and 7.253kb) of the mtDNA associated with the common deletion in blood leukocytes, buccal mucosa and hair follicles

(2010) Emna Mkaouar-Rebai et al.   MITOCHONDRION

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

(2010) P. H. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

(2010) John A. Capra et al.   PLoS Computational Biology

Effect of monovalent cations and G-quadruplex structures on the outcome of intramolecular homologous recombination

(2009) Paula Barros et al.   FEBS Journal

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

(2009) J. P. Duxin et al.   MOLECULAR AND CELLULAR BIOLOGY

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

Nature of Mitochondrial DNA Deletions in Substantia Nigra Neurons

(2008) Amy K. Reeve et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition

(2008) Taro Masuda-Sasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological and Biochemical Defects in Carboxyl-terminal Mutants of Mitochondrial DNA Helicase

(2008) Yuichi Matsushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotype and phenotype analyses in 136 patients with single large-scale mitochondrial DNA deletions

(2008) Shintaro Yamashita et al.   JOURNAL OF HUMAN GENETICS

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

(2008) Li Zheng et al.   MOLECULAR CELL

Detection of mitochondrial DNA deletions in the cochlea and its structural elements from archival human temporal bone tissue

(2008) Adam Markaryan et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS